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| 1 | TTYH2,a human homologue of the Drosophila melanogaster gene tweety,is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation显示文摘AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the expression of TTYH2 in colon cancer cell lines.METHODS: We investigated the expression patterns of TTYH2 in colon cancer, adjacent non-tumorous colon mucosa, and cancer cell lines (DLD-1, caco-2, and Lovo) by RT-PCR. Furthermore, a siRNA plasmid expression vector against TTYH2 was constructed and transfected into DLD-1 and Caco-2 with LipofectamineTM 2000. The down regulation of TTYH2 expression was detected by RT-PCR and the role of siRNA in inducing cell proliferation and cell aggregation was evaluated by MTT and aggregation assay.RESULTS: TTYH2 gene expression in colon cancer tissue was significantly up-regulated compared with normal colonic mucosa (1.23 ± 0.404 vs 0.655 ± 0.373, P = 0.0103). Colon cancer derived cell lines including DLD-1, Caco-2, and Lovo also expressed high levels of TTYH2. In contrast, transfection with siRNA-TTYH2 signifi cantly inhibited both proliferation and scattering of these cancer cell lines.CONCLUSION: The present work demonstrates, for the fi rst time, that the TTYH2 gene expression is signifi cantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating andmetastatic potentials of colorectal cancer. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Junichirou Hiro Yasuhiro Inoue Tomonari Tutumi Chikao Miki Masato Kusunoki | 2007 | World Journal of Gastroenterology2007，13，19： | 4 |
| 2 | 除尘技术研究进展和袋式除尘ISO标准(英文)显示文摘目的:分析当前最新的针对烟气中颗粒物的高效脱除技术,包括静电除尘和袋式除尘的提效方法、原理以及所能达到的效果等;对研究现状进行评述和对未来发展做出展望,并介绍袋式除尘的相关ISO标准。创新点:1.总结了各参数对静电除尘器(包括低低温静电除尘、高温静电除尘和湿式静电除尘等)除尘效率的影响;2.分析比较了不同结构形式的滤袋并总结了适应更高过滤要求的新型过滤材料。方法:1.通过数据分析,比较不同粒径、比电阻和温度对静电除尘器除尘效率的影响,并提出相关改进措施;2.比较不同形式滤袋的收尘特点,结合ISO标准和当前工业需求,对袋式除尘进行展望。结论:1.为保证除尘效率,对于不同特性的粉尘,可采取不同形式的静电除尘器增效技术;2.为满足更高的过滤要求,在袋式除尘器方面,急需开发新型过滤材料和优化清灰技术,以适应更高的温度和满足更高的清灰要求。 | Cheng-hang ZHENG Chikao KANAOKA | 2018 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2018，19，1： | 4 |
| 3 | Prognostic Significance of Host- and Tumor-Related Factors in Patients with Gastric Cancer显示文摘 | Yasuhiko Mohri Kouji Tanaka Masaki Ohi Takeshi Yokoe Chikao Miki Masato Kusunoki | 2010 | World Journal of Surgery2010，，2： | 3 |
| 4 | Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy显示文摘 | Susumu Saigusa Koji Tanaka Yuji Toiyama Takeshi Yokoe Yoshinaga Okugawa Yasuhiro Ioue Chikao Miki Masato Kusunoki | 2009 | Annals of Surgical Oncology2009，，： | 2 |
| 5 | Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma显示文摘AIM: A few studies have applied genomic-wide gene expression analysis in inflamed colon tissue sample in ulcerative colitis (UC). We reported the first study of non-inflamed mucosal gene expression in UC and explored its clinical implication.METHODS: Non-inflamed mucosa was obtained from 6 UC patients who received total colectomy. The gene expression of UC in noninfliamed mucosa was monitored with a microarray. For a selected gene, RT-PCR was performed to verify array results and to further examine expression pattern in inflamed mucosa of UC, colorectal cancer tissue and normal mucosa using additional matched pairs.RESULTS: Two genes showing 2.5-fold decreased expression with significance set at in UC samples were bomeo box a4 (HOXa4) and mads box transcription enhancer factor 2, polypeptide B (MEF2b). RT-PCR showed that MEF2b expression in non-inflamed mucosa was significantly downregulated, whereas the expression of MEF2b increased in accordance with the severity of mucosal inflammation. HOXa4 expression both in inflamed and non-inflamed mucosa in UC was consistently downregulated, and the downregulation of HOXa4 was also found in colorectal carcinoma.CONCLUSION: It is suggested that the MEF2b expression in UC which increase in accordance with inflammation may be induced by the inflammatory mediator. In contrast the downregulation of HOXa4 may be partly involved in the pathogenesis of disease including UC and UC-related carcinogenesis. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Toshimitsu Araki Shigeyuki Yoshiyama Kouhei Sakaguchi Chikao Miki Masato Kusunoki | 2005 | World Journal of Gastroenterology2005，11，33： | 2 |
| 6 | Prolonged Endoplasmic Reticulum Stress in Hypertrophic and Failing Heart After Aortic Constriction: Possible Contribution of Endoplasmic Reticulum Stress to Cardiac Myocyte Apoptosis显示文摘 | Ken-ichiro Okada Tetsuo Minamino Yoshitane Tsukamoto Yulin Liao Osamu Tsukamoto Seiji Takashima Akio Hirata Masashi Fujita Yoko Nagamachi Takeshi Nakatani Chikao Yutani Kentaro Ozawa Satoshi Ogawa Hitonobu Tomoike Masatsugu Hori Masafumi Kitakaze | 2004 | Circulation2004，，6： | 2 |
| 7 | Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy显示文摘 | Susumu Saigusa MD Koji Tanaka MD Yuji Toiyama MD Takeshi Yokoe MD Yoshinaga Okugawa MD Yasuhiro Ioue MD PhD Chikao Miki MD PhD Masato Kusunoki MD PhD | 2009 | Annals of Surgical Oncology2009，，12： | 2 |
| 8 | Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina显示文摘 | Toshiaki Otsuka Chikao Ibuki Takeshi Suzuki Kensuke Ishii Hiroshi Yoshida Eitaro Kodani Yoshiki Kusama Hirotsugu Atarashi Hiroshi Kishida Teruo Takano Kyoichi Mizuno | 2008 | Coronary Artery Disease2008，，2： | 2 |
| 9 | Effects of Brain-Derived Neurotrophic Factor (BDNF) on Compression-Induced Spinal Cord Injury: BDNF Attenuates Down-Regulation of Superoxide Dismutase Expression and Promotes Up-Regulation of Myelin Basic Protein Expression显示文摘 | OSAMU IKEDA MASAZUMI MURAKAMI HIDETOSHI INO MASASHI YAMAZAKI MASAO KODA CHIKAO NAKAYAMA HIDESHIGE MORIYA | 2002 | JNEN: Journal of Neuropathology & Experimental Neurology2002，，2： | 2 |
| 10 | A system for computer-assisted design of stent-graft for aortic aneurysms using 3-D morphological models显示文摘 | Yasuhiro I Shin-ich U Chikao U | 2001 | Cardiovasc Intervent Radiol2001，24，： | 2 |
| 11 | Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity显示文摘 | Yuki Kawakami Tomoko Hosokawa Tomoko Morinaka Shioka Irino Shiori Hirano Hirokazu Kobayashi Akiko Yoshioka Toshiko Suzuki-Yamamoto Miyuki Yokoro Masumi Kimoto Hideaki Tsuji Hiromi Yamashita Shinobu Doi Chikao Yutani Rina Kato Hiroyuki Itabe Teruyuki Kanad | 2011 | Food Chemistry2011，，4： | 1 |
| 12 | Activating mechanism of CNTF and related cytokines显示文摘 | Makoto Inoue Chikao Nakayama Hiroshi Noguchi | 1996 | Molecular Neurobiology1996，，3： | 1 |
| 13 | COLLECTION MECHANISMS OF ELECTRET FILTER显示文摘 | Hitoshi Emi Chikao Kanaoka Yoshio Otani Tomoaki Ishiguro | 1987 | Particulate Science and Technology1987，，2： | 1 |
| 14 | Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy显示文摘 | Susumu Saigusa MD Koji Tanaka MD Yuji Toiyama MD Takeshi Yokoe MD Yoshinaga Okugawa MD Yasuhiro Ioue MD PhD Chikao Miki MD PhD Masato Kusunoki MD PhD | 2009 | Annals of Surgical Oncology2009，，12： | 1 |
| 15 | Immune?maximizing (IMAX) therapy for cancer: Combination of dendriticcell vaccine and intensity?modulated radiation显示文摘 | Yuta Shibamoto Masato Okamoto Masanori Kobayashi Shiho Ayakawa Hiromitsu Iwata Chikao Sugie Yoko Mitsuishi Hidenori Takahashi | 2013 | Molecular and Clinical Oncology2013，，： | 1 |
| 16 | Pressure drop of air filter with dust load 显示文摘 | CHIKAO Kanaoka SOTOJI Hiragi | 1990 | J Aerosol Sci1990，21，1： | 1 |
| 17 | Atmospheric temperature measurement with the rotational Raman lidar using Na vatpor filter显示文摘 | Masahiro Funada Chikao Nagasawa Yasukuni Shibata | | 0，，： | 1 |
| 18 | Adsorption of benzoic acid and phenol from aqueous solution by activated carbon--effects of surface acidity显示文摘 | HIRODAJU O MUNEBARU K CHIKAO Y | 1981 | Carbon1981，19，4： | 1 |
| 19 | Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects显示文摘 | Noriko Otsuki Nam H. Dang Emi Kumagai Akira Kondo Satoshi Iwata Chikao Morimoto | 2009 | Journal of Ethnopharmacology2009，，3： | 1 |
| 20 | Clinical Significance of Human Kallikrein7 Gene Expression in Colorectal Cancer显示文摘 | Yasuhiro Inoue Takehiko Yokobori Takeshi Yokoe Yuji Toiyama Chikao Miki Koshi Mimori Masaki Mori Masato Kusunoki | 2010 | Annals of Surgical Oncology2010，，11： | 1 |
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