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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis显示文摘AIM To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy.METHODS Scopus, Cochrane databases, MEDLINE/Pub Med, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy(EAC) to standard colonoscopy, for any indication, were included in the analysis. The analysis was conducted by using the Mantel-Haenszel or DerS imonian and Laird models with the odds ratio(OR) to assess adenoma detection, cecal intubation rate, and complications performed. RESULTS Nine studies(n = 5624 patients) were included in the analysis. Compared to standard colonoscopy, procedures performed with EC had higher frequencies for adenoma(OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessile serrated adenomas detection(OR = 2.34 95%CI: 1.63-3.36; P < 0.001). There was no significant difference in cecal intubation rates between the EACgroup and standard colonoscopy(OR = 1.26, 95%CI: 0.70-2.27, I2 = 0%; P = 0.44). EAC was associated with a higher risk of complications, most commonly being superficial mucosal injury without higher frequency for perforation.CONCLUSION The use of an EC on colonoscopy appears to improve pre-cancerous polyp detection without any difference in cecal intubation rates compared to standard colonoscopy. | Matthew Chin William Karnes M Mazen Jamal John G Lee Robert Lee Jason Samarasena Matthew L Bechtold Douglas L Nguyen | 2016 | World Journal of Gastroenterology2016，22，43： | 4 |
| 3 | A hybrid rough-cut process planning for quality 显示文摘 | Chin K S Zheng L Y Wei L | 2003 | International Journal of Advanced Manufacturing Teehnology2003，22，910： | 2 |
| 4 | An Interactive Knowledge-Based CAD System For Mould Design in Injection Moulding Processes显示文摘 | C. K. Mok K. S. Chin John K. L Ho | 2001 | International Journal of Advanced Manufacturing Technology2001，，1： | 2 |
| 5 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 6 | New Generation NSAIDs: The Benefit Without the Risk显示文摘 | WALLACE J L CHIN B C | 1997 | Drugs Today1997，33，： | 1 |
| 7 | Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure显示文摘 | Miettinen PJ Chin JR Shum L | 1999 | Nat Genet1999，22，： | 1 |
| 8 | Application of Neural Networks in Target Tracking Data Fusion显示文摘 | Chin L | 1994 | IEEE Trans on Aerospace and Electronic Systems(S0018-9251)1994，30，1： | 1 |
| 9 | Cancer genomics: from discovery science to personalized medicine显示文摘 | Chin L Andersen JN Futreal PA | 2011 | Nat Med2011，17，3： | 1 |
| 10 | Fahrieation of carbon nano-tuhes decorated with ultra fine superparamagnetic nano-particles under continuous flow conditions显示文摘 | CHIN S F IYER K S TASTON C L | 2008 | Lab on a Chip2008，8，3： | 1 |
| 11 | The effect of innova- tive activity on firm performance: the experience ofTaiwan 显示文摘 | ANANDARAJAN A CHIN C - L CHI H - Y | 2007 | Ad- vances in Accounting2007，23，1： | 1 |
| 12 | Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer显示文摘 | Chalasani V Chin J L Izawa J I | 2009 | Can Urol Assoc J2009，3，64： | 1 |
| 13 | Corrosion electrochemical behavior of epoxy anticorrosive paints based on zinc molybdenum phosphate and zinc oxide显示文摘 | Veleva L Chin J Amo B | 1999 | Progress in Organic Coatings1999，，36： | 1 |
| 14 | Kinetics and mechanisms of kaolinite dissolution:effects of organic ligands 显示文摘 | Chin P K F Mills G L | 1991 | Chemical Geology1991，90，： | 1 |
| 15 | Mechanism of hemoglobin-induced protection against endotoxemia in rats:a ferritin-independent pathway显示文摘 | Otterbein L Chin DY Otterbein SL | 1997 | American Journal of Physiology1997，272，： | 1 |
| 16 | The INK4a/ARF locus and melanoma显示文摘 | Harpless E Chin L | 2003 | Oncogene2003，22，： | 1 |
| 17 | Hydroxyapatite coating on Ti-6Al-4V alloy using a sol -gel derived precursor显示文摘 | Hsieh M F Perng L H Chin T S | 2002 | Materials Chemistry and Physics2002，，74： | 1 |
| 18 | Bulk elastic wave propagation in partially saturated porous solids 显示文摘 | Berryman J G Thigpen L Chin R C Y | 1988 | Jourual of the Acoustical Society of America1988，84，1： | 1 |
| 19 | Corrosion Electrochemical Behavior of Epoxy Anticorrosive Paints Based on Zinc Molybdenum Phosphate and Zinc Oxide显示文摘 | Veleva L Chin J Amo B D | 1999 | Progress in Organic Coatings1999，，04： | 1 |
| 20 | Wastewater treatment with bacterial augmentation显示文摘 | Chin K K Ong S L Poh L H | 1998 | Water Sci Technol1998，33，8： | 1 |
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