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| 1 | MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs. | Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho | 2018 | World Journal of Gastroenterology2018，24，27： | 29 |
| 2 | Ventricular tach- ycardia- like electrocardiographic artifact on total thyroidectomy显示文摘 | Cho YS Kim JY Kim KW | 2013 | Korean J Anesthesiol2013，65，6： | 1 |
| 3 | Presence of immunoreactive atrial natriuretic peptide in follicular fluid, ovary and ovarian perfusates显示文摘 | Kim SH Cho KW Seul KH | 1989 | Life Sci1989，45，： | 1 |
| 4 | Risk of hepatitis B exacerbation is low after transcatheter arterial chemoembolization therapy for patients with HBV related hepatocellular carcinoma:report of a prospective study显示文摘 | PARK JW PARK KW CHO SH | 2005 | Am J Gastroenterol2005，100，： | 1 |
| 5 | Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappa B- and p38 MAPK-dependent signalling pathways显示文摘 | Kim HR Cho ML Kim KW | 2007 | Rheumatology (Oxford)2007，46，： | 1 |
| 6 | Oleanohc acid in- creases plasma ANP levels via an accentuation of cardiac ANP synthesis and secretion in rats显示文摘 | Kim HY Cho KW Kang DG | 2013 | Eur J Pharmacol2013，710，13： | 1 |
| 7 | Usefulness 18F-FDG positron emission tomography/computed tomography for detecting recurrence of hepatocellular carcinoma in postt-ransplant patients显示文摘 | Kim YK Lee KW Cho SY | | 0，，： | 1 |
| 8 | Endogenous ACh tonicallystimulates ANP secretion in rat atria 显示文摘 | Kim HY Cho KW Xu DY | 2013 | Am J Physiol HeartCire Physiol2013，305，7： | 1 |
| 9 | Large intracranial aneurysm after transs- phenoidal surgery for pituitary macroadenoma显示文摘 | Yoon KW Cho CS Lee SK | 2014 | J Korean Neurosurg Soc2014，55，3： | 1 |
| 10 | Sinus thrombosis in a patient with intracranial hypotension: a suggested hypothesis of venous stasis, a case report 显示文摘 | Yoon KW Cho MK Kim YJ | 2011 | Interv Neuroradiol2011，17，： | 1 |
| 11 | Role of magnetic res- onance imaging and positron emission tomography/compu- ted tomography in preoperative lymph node detection of u- terine cervical cancer 显示文摘 | Chang HH Kang KW Cho JY | 2010 | Am J Obstet Gynecol2010，203，2： | 1 |
| 12 | Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2and TLR-4activation显示文摘 | Kim KW Cho ML Lee SH | 2007 | Immunol Lett2007，110，1： | 1 |
| 13 | Arsenic levels in human hair, Kandal Province, Cambodia: The influences of groundwater arsenic, consumption period, age and gender 显示文摘 | Sthiannopkao S Kim KW Cho KH | 2010 | Appl Geochemistry2010，25，： | 1 |
| 14 | Paratrooper's ankle fractnre : pos- terior malleolar fracture显示文摘 | Young KW Kim JS Cho JH | 2015 | Clin Orthop Surg2015，7，1： | 1 |
| 15 | Data mining approach to pllicy analysis in a health insurance domain显示文摘 | Chae YM Ho SH Cho KW | 2001 | International J Med Informat2001，62，： | 1 |
| 16 | Gender and Prevalence of Knee Osteoarthritis Types in Elderly Koreans显示文摘 | Cho HJ Chang CB Kim KW | 2011 | The Journal of Arthro- plasty2011，26，7： | 1 |
| 17 | Effects of sFlt-1 and alpha 2-macro- globulin on vascular endothelial growth factor-induced endothelin- 1 upregnlation in human microvascular endothelial cells显示文摘 | Yi KW Jung SH Cho GJ | 2014 | Placenta2014，35，1： | 1 |
| 18 | Molecular biomarker of inflammatory response is associated with rebleeding in spontaneous intracerebral hemorrhage显示文摘 | Wang KW Cho CL Chen HJ | 2011 | European Neurology2011，66，6： | 1 |
| 19 | Congenital absence of the gallbladder显示文摘 | Cho CH Suh KW Min JS | 1992 | Yonsei Med J1992，33，： | 1 |
| 20 | A pharmaeodynamje study of sorafenib in patients with relapsed and refractory acute leukemills 显示文摘 | Pratz KW Cho EI Evis MJ | 2010 | Leukemia2010，24，8： | 1 |
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