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| 1 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Endothelin-1 decreases posteapillary fluid efflux via prostacyclin release显示文摘 | Vietorino G P Chong T J Curran B | 2004 | Surgery2004，136，2： | 1 |
| 4 | Strong resonance and a highly compact long period grating in a large-mode-area photonic crystal fiber 显示文摘 | Zhu Y N Shum P Chong H J | 2003 | Optics Express2003，11，16： | 1 |
| 5 | Subspace Expansion and the Equivalence of Conjugate Direction and Multistage Wiener Fihers显示文摘 | Scharf L L Chong E K P Zohowski M D | 2008 | IEEE Trans on Signal Processing2008，56，10： | 1 |
| 6 | Increasing prostate biopsy cores based on volume vs the sextant biopsy: a prospective randomized controlled clinical study on cancerdetection rates and morbidity 显示文摘 | MARIAPPAN P CHONG WL SUNDRAM M | 2004 | BJU Int2004，94，3： | 1 |
| 7 | A study of compact spun yarns显示文摘 | CHONG K P S YU C | 2003 | Textile Research Journal2003，73，4： | 1 |
| 8 | CDMA Systems in Fading Channels:Admissibility,Network Capacity,and Power Control显示文摘 | ZHANG J S CHONG E K P | 2000 | IEEE Trans2000，46，3： | 1 |
| 9 | Surface modification of a granular activated carbon by citric acid lbr enhancement of copper absorption 显示文摘 | Chen J P Wu S N Chong K H | 2003 | Carbon2003，41，： | 1 |
| 10 | Sensor Networks:Evolution,Oppor-tunities,and Challenges显示文摘 | Kumar S P | 2003 | Proceedings of the IEEE2003，91，8： | 1 |
| 11 | A survey of clustering scheme for mobile ad hoc networks 显示文摘 | Yu J Y Chong P H J | 2005 | IEEE Communications Surveys and Tuto- rials2005，7，1： | 1 |
| 12 | Immunological study of hal domain of he- magglutinin of influenza hSnl virus 显示文摘 | Chiu F F Venkatesan N Wu C R Chou A H Chen H W Lian S P Liu SJ Huang C C Lian W C Chong P Leng C H | 2009 | Biochemical Biophys ResCommun2009，383，1： | 1 |
| 13 | An integrated hy- pothesis that considers drusen as biomarkers of immune- mediated processes at the RPE-Bruch' s membrane inter- face in aging and age-related macular degeneration显示文摘 | HAGEMAN GS LUTHERT P J VICTOR CHONG NH JOHN- SON LV ANDERSON DH MULLINS RF | 2001 | Prog Retin Eye Res2001，20，6： | 1 |
| 14 | Impact of Caregiving on Health and Quality of Life : A Comparative Popu- lation-based Study of Caregivers for Elderly Persons and Noncaregivers 显示文摘 | Ho S C Chan A Woo J Chong P and Sham A | 2009 | Journals of Gerontology Series A: Biologi- cal Sciences and Medical Sciences2009，64，： | 1 |
| 15 | 显示文摘 | PE3TERSSON L G M LANGHOFF S R CHONG D P | 1986 | J Chem Phys1986，85，： | 1 |
| 16 | Repair and regeneration:experimental aspects of spinal cord disease显示文摘 | Payne J H Wall P D Chong M S | 1992 | Curr Opin Neurol Neurosurg1992，5，4： | 1 |
| 17 | Sensor Networks:Evolution,Opportunities,and Challenges显示文摘 | Chee-Yee Chong Kumar S P | 2003 | Proc of the IEEE2003，91，8： | 1 |
| 18 | Sensor networks: evolution, opportunities, and challenges 显示文摘 | CHONG C KUMAR S P | 2003 | Proceedings of the IEEE2003，91，8： | 1 |
| 19 | Current industrial practices of assessing permeability and P-glycoprotein interaction显示文摘 | Balimane P V Han Y H Chong S | 2006 | AAPS J2006，8，1： | 1 |
| 20 | A High-perfor-mance Thermoelectric Material for Low-temperature Applications 显示文摘 | Chong D Y Hong T Brazis P | 2000 | Science2000，287，： | 1 |
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