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| 1 | Alveolar echinococcosis-spreading disease challenging clinicians: A case report and literature review显示文摘Human alveolar echinococcosis (AE) is a potentially deadly disease; recent studies have shown that the endemic area of Echinococcus multilocularis , its causative agent, is larger than previously known. This disease has low prevalence and remains underreported in Europe. Emerging clinical data show that diagnostic difficulties are still common. We report on a 76-year old patient suffering from AE lesions restricted to the left lobe of the liver who underwent a curative extended left hemihepatectomy. Prior to the resection a liver biopsy under the suspicion of an atypical malignancy was performed. After the intervention he developed a pseudoaneurysm of the hepatic artery that was successfully coiled. Surprisingly, during surgery, the macroscopic appearance of the tumour revealed a growth pattern that was rather typical for cystic echinococcosis (CE), i.e. , a gross tumour composed of multiple large vesicles with several centimeters in diameter. In addition, there were neither extensive adhesions nor infiltrations of the neighboring pancreas and diaphragm as was expected from previous imaging results. The unexpected diagnosis of AE was confirmed by definite histopathology, specific polymerase chain reaction and serology results. This is a rare case of unusual macroscopic presentation of AE that posed immense diagnostic challenges and had an eventful course. To our knowledge this is the first case of an autochthonous infection in this particular geographic area of Germany, the federal state of Saxony. This report may provide new hints for an expanding area of risk for AE and emphasizes the risk of complications in the scope of diagnostic procedures and the limitations of modern radiological imaging. | Georgi Atanasov Christoph Benckert Armin Thelen Dennis Tappe Matthias Frosch Dieter Teichmann Thomas FE Barth Christian Wittekind Stefan Schubert Sven Jonas | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 4 |
| 3 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 4 | Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors显示文摘AIM:To investigate in vitro and in vivo treatment with histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589 in pancreatic cancer. METHODS:Cell-growth inhibition by NVP-LAQ824 and NVP-LBH589 was studied in vitro in 8 human pancreatic cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide(MTT) assay. In addition,the anti-tumoral effect of NVP-LBH589 was studied in a chimeric mouse model. Anti-tumoral activity of the drugs was assessed by immunoblotting for p21WAF-1,acH4,cell cycle analysis,TUNEL assay,and immunohistochemistry for MIB-1. RESULTS:In vitro treatment with both compounds significantly suppressed the growth of all cancer cell lines and was associated with hyperacetylation of nucleosomal histone H4,increased expression of p21WAF-1,cell cycle arrest at G2/M-checkpoint,and increased apoptosis. In vivo,NVP-LBH589 alone significantly reduced tumor mass and potentiated the efficacy of gemcitabine. Further analysis of the tumor specimens revealed slightly increased apoptosis and no significant reduction of cell proliferation.CONCLUSION:Our findings suggest that NVP-LBH589 and NVP-LAQ824 are active against human pancreatic cancer,although the precise mechanism of in vivo drug action is not yet completely understood. Therefore,further preclinical and clinical studies for the treatment of pancreatic cancer are recommended. | Martin Haefner Thilo Bluethner Manuel Niederhagen Christian Moebius Christian Wittekind Joachim Mossner Karel Caca Marcus Wiedmann | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 5 | Surgical treatment of hepatocellular carcinoma: Experience with liver resection and transplantation in 198 patients显示文摘 | Burckhardt Ringe M.D. Rudolf Pichlmayr M.D. Christian Wittekind M.D. Günter Tusch M.S | 1991 | World Journal of Surgery1991，，2： | 2 |
| 6 | Role of epigenetic alterations in cholangiocarcinoma显示文摘 | Iris Tischoff Christian Wittekind Andrea Tannapfel | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，4： | 2 |
| 7 | Surgical treatment of hepatocellular carcinoma: Experience with liver resection and transplantation in 198 patients显示文摘 | Burckhardt Ringe M.D. Rudolf Pichlmayr M.D. Christian Wittekind M.D. Günter Tusch M.S | 1991 | World Journal of Surgery1991，，2： | 1 |
| 8 | Mutations of p53 Tumor Suppressor Gene, Apoptosis, and Proliferation in Intrahepatic Cholangiocellular Carcinoma of the Liver显示文摘 | Andrea Tannapfel Lars Weinans Felix Gei?ler Alexander Sch?tz Alexander Katalinic Ferdinand K?ckerling Johann Hauss Christian Wittekind | 2000 | Digestive Diseases and Sciences2000，，2： | 1 |
| 9 | Surgical treatment of hepatocellular carcinoma: Experience with liver resection and transplantation in 198 patients显示文摘 | Burckhardt Ringe M.D. Rudolf Pichlmayr M.D. Christian Wittekind M.D. Günter Tusch M.S | 1991 | World Journal of Surgery1991，，2： | 1 |
| 10 | Protective Effects of Early CD4+ T Cell Reduction in Hepatic Ischemia/Reperfusion Injury显示文摘 | Mathias Martin Christina Mory Andrea Prescher Christian Wittekind Martin Fiedler Dirk Uhlmann | 2010 | Journal of Gastrointestinal Surgery2010，，3： | 1 |
| 11 | Surgical and Palliative Management and Outcome in 184 Patients With Hilar Cholangiocarcinoma: Palliative Photodynamic Therapy Plus Stenting Is Comparable to R1/R2 Resection显示文摘 | Helmut Witzigmann Frieder Berr Ulrike Ringel Karel Caca Dirk Uhlmann Konrad Schoppmeyer Andrea Tannapfel Christian Wittekind Joachim Mossner Johann Hauss Marcus Wiedmann | 2006 | Annals of Surgery2006，，2： | 1 |
| 12 | Caroli’s disease: Liver resection and liver transplantation. Experience in 33 patients显示文摘 | Woubet Tefera Kassahun Thomas Kahn Christian Wittekind Joachim M?ssner Karel Caca Johann Hauss Peter Lamesch | 2005 | Surgery2005，，5： | 1 |
| 13 | Adjuvant versus Neoadjuvant Radiochemotherapy for Locally Advanced Rectal Cancer A Progress Report of a Phase-III Randomized Trial (Protocol CAO/ARO/AIO-94)显示文摘 | Rolf Sauer Rainer Fietkau Christian Wittekind Peter Martus Claus R?del Werner Hohenberger Gerhard Jatzko Hubert Sabitzer Johann-Hinrich Karstens Heinz Becker Clemens Hess Rudolf Raab | 2001 | Strahlentherapie und Onkologie2001，，4： | 1 |
| 14 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 1 |
| 15 | Gastric carcinoma: stage migration by immunohistochemically detected lymph node micrometastases显示文摘 | Theresa L. A. Jeuck Christian Wittekind | 2015 | Gastric Cancer2015，，1： | 1 |
| 16 | Caroli’s disease: Liver resection and liver transplantation. Experience in 33 patients显示文摘 | Woubet Tefera Kassahun Thomas Kahn Christian Wittekind Joachim M?ssner Karel Caca Johann Hauss Peter Lamesch | 2005 | Surgery2005，，5： | 1 |
| 17 | Complete resection in lung cancer surgery: proposed definition显示文摘 | Ramón Rami-Porta Christian Wittekind Peter Goldstraw | 2005 | Lung Cancer2005，，1： | 1 |
| 18 | Surgical treatment of hepatocellular carcinoma: Experience with liver resection and transplantation in 198 patients显示文摘 | Burckhardt Ringe M.D. Rudolf Pichlmayr M.D. Christian Wittekind M.D. Günter Tusch M.S | 1991 | World Journal of Surgery1991，，2： | 1 |
| 19 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 1 |
| 20 | Efficacy of Radiochemotherapy with Platin Derivatives Compared to Radiotherapy Alone in Organ-Sparing Treatment of Bladder Cancer显示文摘 | Rolf Sauer Stefan Birkenhake Reinhard Kühn Christian Wittekind Karl Michael Schrott Peter Martus | 1998 | International Journal of Radiation Oncology Biology Physics1998，，1： | 1 |
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