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您的检索式：作者名="Christopher Nimsky"
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| 1 | 多模态神经导航辅助下的术中磁共振显示文摘作者简介:Christopher Nimsky.德国Marburg大学医学院神经外科主任,神经外科教授,博士,世界术中影像学会副主席,德同神经外科学会副主席。长期从事神经外科和神经影像学的研究。在弥散张量成像(DTI)及自质纤维束示踪技术和神经导航技术方面有很丰富的经验。发表DTI相关的研究论文多篇.是世界知名的DTI及功能神经导航专家. | Christopher Nimsky 陈晓雷 | 2012 | 中国神经精神疾病杂志2012，38，4： | 3 |
| 2 | Intraoperative High-Field-Strength MR Imaging:Implementation and Experience in 200 Patients显示文摘 | Christopher Nimsky Oliver Ganslandt Boris von Keller | 2004 | Radiology2004，233，1： | 1 |
| 3 | MicroRNA-149 Regulates Proliferation,Migration,and Invasion of Pituitary Adenoma Cells by Targeting ADAM12 and MMP14显示文摘Objective Pituitary adenomas(PAs)can adapt an aggressive phenotype by invading adjacent brain structures with rapid cellular proliferation.Previous studies demonstrated that excessive expression of metalloproteases ADAM12 and MMP-14 is instrumental for the active proliferation and invasiveness of PA cells in vitro and of tumors in vivo.However,the mechanisms regulating ADAM12 and MMP-14 expression in PAs remain unclear.Methods Target gene prediction and transcriptomic profiling of invasive vs.noninvasive human PA samples were performed to identify miRNA species potentially involved in the regulation of ADAM12 and MMP14.For cellular analyses of miRNA functions,two mouse PA cell lines(AtT20 and TtT/GF)were transfected with miR-149-3p and miR-149-5p,respectively.The effects of miR-149(3p and 5p)on expression levels of ADAM12 and MMP14 were determined by Western blotting followed by an analysis of proliferation and colony formation assays,scratch migration assays,and invasion assays.Results A significant downregulation of miRNA-149 was observed in invasive vs.noninvasive PA(0.32 vs.0.09,P<0.0001).In AtT-20 and TtT/GF mouse PAs cells,transfection of mimic miRNA-149(3p and 5p)caused a significantly reduced cell proliferation and matrigel invasion,whilst the effect on cell migration was less pronounced.Both strands of miRNA-149(3p and 5p)markedly reduced protein levels of ADAM12 and MMP-14 by at least 40%in both cell lines.Conclusion This study proved that the invasiveness of PA cells is,at least partly,regulated by miRNA-149-dependent expression of ADAM12 and MMP-14. | Zhuo ZHANG Agnes Schäfer Benjamin Voellger Jun-wen WANG Ting LEI Christopher Nimsky Jörg W.Bartsch | 2022 | Current Medical Science2022，42，6： | 0 |
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