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| 1 | Football injuries of the ankle: A review of injury mechanisms, diagnosis and management显示文摘Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature. | Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 2 | Update on surgical treatment of pancreatic neuroendocrine neoplasms显示文摘Pancreatic neuroendocrine neoplasms(PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential(neurendocrine tumors PNETs) or overt(neuroendocrine carcinomas PNECs) malignant,but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimallyinvasive approaches which should be tailored to the individual patient. Generally,surgeons must aim for parenchyma sparing in these cases. In high-risk and malignant PNENs,indications for tumor resection are much wider than for pancreatic adenocarcinoma,in many cases due to the relatively benign tumor biology. Thus,patients with locally advanced and metastatic PNETs may benefit from extensive resection. In experienced hands,even multi-organ resections are accomplished with acceptable perioperative morbidity and mortality rates and are associated with excellent long term survival. However,poorly differentiated neoplasms with high proliferation rates are associated with a dismal prognosis and may frequently only be treated with chemotherapy. The evidence on surgical treatment of PNENs stems from reviews of mostly singlecenter series and some analyses of nation-wide tumor registries. No randomized trial has been performed to compare surgical and non-surgical therapies in potentially resectable PNEN. Though such a trial would principally be desirable,ethical considerations and the heterogeneity of PNENs preclude realization of such a study. In the current review,we summarize recent advances in the surgical treatment of PNENs. | Jan G D’Haese Chiara Tosolini Güralp O Ceyhan Bo Kong Irene Esposito Christoph W Michalski J?rg Kleeff | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 3 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 4 | Paraesophageal hernia and iron deficiency anemia:Mechanisms,diagnostics and therapy显示文摘There is ample clinical evidence suggesting that the presence of large axial or paraesophageal hernias may lead to iron deficiency anemia.So-called Cameron lesions,as well as other small mucosa erosions,in the sliding area of these diaphragmatic hernias lead to invisible chronic blood loss and consequently to iron depletion.While the spectrum of symptoms in these patients is large,anemia is often not the only indication and typically not the primary indication for surgical correction of diaphragmatic hernias.Drug treatment with proton pump inhibitors and iron substitution can alleviate anemia,but this is not always successful.To exclude other possible bleeding sources in the gastrointestinal tract,a comprehensive diagnostic program is necessary and reviewed in this manuscript.Additionally,we discuss controversies in the surgical management of paraesophageal hernias. | Christoph G Dietrich Dolores Hübner Joachim W Heise | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 2 |
| 5 | Connell integrate the effects of climate change across entire systems that predicting ecosystem shifts requires new approaches显示文摘 | Bayden D R Christopher D G H Thomas W | | 0，，10： | 1 |
| 6 | Risk as feelings显示文摘 | boewenstein G F Elke U W Christopher K H Welch N | 2001 | Psychological Bulletin2001，127，2： | 1 |
| 7 | Interleukin-6and its receptors:A highly regulated and dynamic system显示文摘 | Janina W Stefan RJ Christoph G | 2014 | Cytokine2014，70，1： | 1 |
| 8 | Proton radiography显示文摘 | CHRISTOPHER M JOHN W H PHLLIP G | 2006 | Los Alamos Science2006，，： | 1 |
| 9 | Treatment of heart failure guided by plasma aminoterminal brain na- triuretic peptide( N-BNP ) concentrations 显示文摘 | Richard W Troughton Christopher M Frampton Timothy G Yandle | 2000 | The Lancet2000，355，9210： | 1 |
| 10 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 11 | Does the prevention of complications explain the survival benefit of organized inpatient (stroke unit) care? Further analysis of a systematic review显示文摘 | Lindsay G Peter L Christopher J W | 2007 | Stroke2007，38，： | 1 |
| 12 | Atheroselerosis: the road ahead 显示文摘 | Christopher K G Joseph L W | 2001 | Cell2001，104，4： | 1 |
| 13 | Natural area visitors' place meaning and place attachment ascribed to a marine setting 显示文摘 | Christopher J W Gerard T K Stephen G S | 2012 | Journal of Environmental Psychology2012，32，4： | 1 |
| 14 | On an approximate minimax circle closest to a set of points 显示文摘 | SAUL I GASS CHRISTOPH W G | 2004 | Journal of Computers and Operations Research2004，3，2： | 1 |
| 15 | Production of liquid alkanes by aqueous-phase pro- cessing of biomass-derived carbohydrates 显示文摘 | G W HUBER J N CHHEDA J B CHRISTOPHER | 2005 | Science2005，308，5727： | 1 |
| 16 | Investigation of TRPV1 loss-offunction phenotypes in transgenic shRNA expressing and knockout mice显示文摘 | Christoph T Bahrenberg G Vry J D Englberger W Erdmann V A Frech M | 2008 | Mol Cell Neurosci2008，37，： | 1 |
| 17 | Steroid Receptor Coactivator Expression throughout the Menstrual Cycle in Normal and Abnormal Endometrium显示文摘 | Christopher W G Elizabeth M W Ruth A L | 2002 | J Clin Endocrinol Metab2002，87，29： | 1 |
| 18 | Preparation and characterization of TAM-Ioaded HPMC/ PAN composite fibers for improving drug-release profiles显示文摘 | SHEN X X YU D G CHRISTOPHER B W | 2011 | Journal of Biomaterials Science-Polymer Edition2011，22，16： | 1 |
| 19 | A P-typeATPase required for rice blast disease and induction of host resistanc显示文摘 | Martin J G Christopher R T Gavin E W eta/ | 2006 | Nature Letters2006，440，23： | 1 |
| 20 | Photovotaic materials, history, status and outlook显示文摘 | Adolf G Christopher H Hans W S | 2003 | Materials Science and Engineering R2003，40，： | 1 |
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