|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 2 | Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study显示文摘Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively examined.We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols.Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke.Extracranial carotid plaques with HRP features were more common in Caucasians.Intracranial plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was found.Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy. | Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 3 | Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis显示文摘我们在一张多样的临床的人口评估了同样需要的 tadalafil 的功效和安全(与改变耐心的人口分布,疾病严厉,和 comorbid 医药条件) 有可勃起的机能障碍(编辑) 的亚洲人。五双窗帘的综合分析,控制安慰剂的试用(N = 1 046 ) 被执行。病人们随机被分配收到 10 mg tadalafil (N = 185 ) , 20 mg tadalafil (N = 510 ) ,或安慰剂(N = 351 ) 。功效评价包括了可勃起的功能(IIEF ) 的国际索引,性相遇侧面(9 月) 日记和全球评价问题(GAQ ) 。收到 10 mg 或 20 mg tadalafil 从 baseline-to-end 看了重要改进的病人指在在分析的所有临床的亚人口的可勃起的功能(IIEF-EF ) 领域 20 的国际索引的可勃起的功能领域上,与收到安慰剂的病人相比(P < 0.001 ) 。给吝啬的成功看的 10-mg 和 20-mg tadalafil 组为性交尝试64.1%和70.5%评价( SEP3 ,成功的性交)分别地,在安慰剂与33.4%相比组织( P < 0.001 ),并且分别地,在结束的85.5%和85.4%报导改进勃起削尖 GAQ 对43.5%在安慰剂组织( P < 0.001 )。Tadalafil 很好越过学习的所有组被容忍。头疼和背疼痛是最经常报导的不利事件。总的来说, tadalafil 越过有编辑的亚洲男人的一个多样的临床的系列有效、很好容忍。 | Ying-Lu Guo Vijay P Viswanathan Han-Sun Chiang Hyung Ki Choi Andrew Wai Chun Yip Wei Shen Vladimir Kopernicky | 2009 | Asian Journal of Andrology2009，11，4： | 3 |
| 4 | Phase Equilibria of Methane and Carbon Dioxide Hydrates in the Aqueous MgC12 Solu- tions 显示文摘 | Kang S P Chun M K Lee H | 1998 | Fluid Phase Equilibria1998，147，12： | 1 |
| 5 | Antioxidant assessment of an anthocyanin-enriched blackberry extract显示文摘 | INGRID E CHUN H DAVID G P | 2007 | Food Chemistry2007，101，： | 1 |
| 6 | Arsenic contamination and potential health risk implications at an abandoned tungsten mine, southern China显示文摘 | Chuan P L Chun L L Yun G | 2010 | Environmental Pollution2010，158，3： | 1 |
| 7 | Consumer mindsets and self-enhancement: Signaling versus learning显示文摘 | Mathur P Chun H H Maheswaran D | 2016 | Journal of ConstnnerPsychology2016，26，1： | 1 |
| 8 | Multicycle performance of a single-step process for H2 production显示文摘 | CHUN Han HARRISON D P | 1997 | Separation Science and Technology1997，32，1234： | 1 |
| 9 | beta-Carotene and beta- apo-14' -carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo显示文摘 | PRAKASH P LIU Chun HU Kangquan | 2004 | Nutr2004，134，3： | 1 |
| 10 | Adjuvant Chemotherapy for Stage II Colon Cancer:The Role of Molecular Markers in Choosing Therapy 显示文摘 | Chun P Wainberg ZA | 2009 | Gastrointest Cancer Res2009，3，5： | 1 |
| 11 | The development of cement and concrete additive : Based on xylonic acid derived via bioconversion of xylose 显示文摘 | CHUN B W DAIR B MACUCH P J | 2006 | Applied Biochemistry and Biotechnology2006，131，123： | 1 |
| 12 | Char- acteristics of bicyclic sesquiterpanes in crude oils and petrole- um products显示文摘 | YANG Chun WANG Zhendi HOLLEBONE B P | 2009 | Journal of Chromatography A2009，1216，20： | 1 |
| 13 | TaintDroid : an information- flow tracking system for realtime privacy monitoring on smartphones 显示文摘 | ENCK W GILBERT P CHUN B G | 2014 | Communications of the ACM2014，57，3： | 1 |
| 14 | Muhicycle performance of a single-step process for H2 production 显示文摘 | Chun Han Douglas P Harrison | 1997 | Separation Science and Technology1997，32，14： | 1 |
| 15 | Nanocrystallization behaviour of Al-Y-Ni with Cu additions 显示文摘 | HONG S J WARREN P J CHUN B S | 2001 | Materials Science and Engineering2001，，304306： | 1 |
| 16 | Effects of light on nitrogen and car- bon uptakeduring a Prorocentrum minimum bloom 显示文摘 | CHUN L F GLIBERT P M | 2005 | Harmful Algae2005，4，3： | 1 |
| 17 | Applications of patient-specific induced pluripotent stem cells;focused on disease modeling,drug screening and therapeutic potentials for liver disease显示文摘 | Chun YS Chaudhari P Jang YY | | 0，，07： | 1 |
| 18 | T-cell cytokines differentially control human monocyte antimicrobial re-sponses by regulating vitamin D metabolism 显示文摘 | EDFELDT K LIU P T CHUN R | 2010 | Proc Nati Acad of Sci USA2010，107，22： | 1 |
| 19 | Tourism development and economic growth: a closer look at panels 显示文摘 | Lee C C Chun P C | 2008 | Tourism Management2008，29，1： | 1 |
| 20 | Pass Schedule Algorithms for Hot Open Die Forging 显示文摘 | Kim P H Chun M S Yi J J | 2002 | Journal of Materials Processing Technology (S0924-0136)2002，130，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员