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| 1 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 2 | Predicting factors for refractory kawasaki disease显示文摘 | Do YS Kim KW Chun JK | 2010 | Korean Circ J2010，40，5： | 1 |
| 3 | Oxygen-dependent and independent regulation of HIF-1 alpha显示文摘 | Chun YS Kim MS Park JW | 2002 | J Korean Med Sci2002，17，5： | 1 |
| 4 | Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression,NF-kappaB activation and tumor promotion显示文摘 | Keum YS Han SS Chun KS | 2003 | Mutat Res2003，，： | 1 |
| 5 | Volumetric changes in the upper airway after bimaxillary surgery for skeletal class llImalocclusions: a case series study using 3-dimensional cone-beam computed tomography显示文摘 | Lee Y Chun YS Kang N | 2012 | J Oral Maxillofac Surg2012，70，12： | 1 |
| 6 | Two-surgeon technique of parenchymal transection contributes to reduced transfusion rate in patients undergoing major hepatectomy: analysis of 1, 557 consecutive liver resections 显示文摘 | Palavecino M Kishi Y Chun YS | 2010 | Surgery2010，147，1： | 1 |
| 7 | Bone density at interradieular sites: implications for orthodontic mini-implant placement 显示文摘 | Chun YS Lim WH | 2009 | Orthod Craniofac Res2009，12，1： | 1 |
| 8 | Predicting factors for refractory kawasaki disease显示文摘 | Do YS Kim KW Chun JK | 2010 | Korean Circ J2010，40，5： | 1 |
| 9 | Management of chemotherapy -associated hepatotoxicity in colorectal liver metastases显示文摘 | Chun YS Laurent A Maru D | 2009 | Lan- cet Onco12009，10，3： | 1 |
| 10 | Hyperbaric oxygenation pretreatment induces catalase and reduces infarct size in ischemic rat myocardium显示文摘 | Kim CH Choi H Chun YS | 2001 | Pflugers Arch2001，442，4： | 1 |
| 11 | New anticancer strategies targeting HIF-1显示文摘 | Yeo EJ Chun YS Park JW | 2004 | Biochem Pharmacol2004，68，6： | 1 |
| 12 | YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1 显示文摘 | Yeo EJ Chun YS Cho YS | 2003 | J Natl Cancer Inst2003，95，7： | 1 |
| 13 | Induced pluripotent stem cells and personalized medicine:current progress and future perspectives显示文摘 | Chun YS Byun K Lee B | 2011 | Anat Cell Biol2011，44，4： | 1 |
| 14 | Human arrest defective 1 acetylates and activates beta-catenin, promoting lung cancer cell prolif eration显示文摘 | Lira JH Park JW Chun YS | 2006 | Cancer Res2006，66，10： | 1 |
| 15 | Role of apoptosis - inducing factor in myocardial cell death by ischemia - reperfusion显示文摘 | Kinma GT Chun YS Park JW | 2003 | Biochem Biophys Res Commun2003，309，： | 1 |
| 16 | YC-1:a potential anticancer drug targeting hypoxia-inducible factor-1 显示文摘 | Yeo EJ Chun YS Cho YS | 2003 | Natl Cancer Inst2003，95，7： | 1 |
| 17 | New antieancer strategies targeting HIF-1显示文摘 | Yeo EJ Chun YS Park JW | 2004 | Biochem Pharmacol2004，68，6： | 1 |
| 18 | Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells显示文摘 | Chun YS Yeo EJ Choi E | 2001 | Biochem Pharmacol2001，61，8： | 1 |
| 19 | yon Hippel-lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase显示文摘 | Li SH Chun YS Lim JH | | 0，，05： | 1 |
| 20 | Implant-based breast reconstruction using acellular dermal matrix and the risk of postoperative complications 显示文摘 | Chun YS Verma K Rosen H | 2010 | Plast Reconstr Surg2010，125，： | 1 |
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