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| 1 | Using aripiprazole to reduce antipsychotic-induced hyperprolactinemia: meta-analysis of currently available randomized controlled trials显示文摘 | Meiling MENG Wei LI Shaowei ZHANG Hongyan WANG Jianhua SHENG Jijun WANG Chunbo LI | 2015 | 上海精神医学2015，27，1： | 22 |
| 2 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 3 | Updated Review on the Clinical Use of Repetitive Transcranial Magnetic Stimulation in Psychiatric Disorders显示文摘With the ability to modulate cortical activity,repetitive transcranial magnetic stimulation(r TMS) is becoming increasingly important in clinical applications for psychiatric disorders. Previous studies have demonstrated its promising efficacy in depression and schizophrenia, and emerging evidence has also been found in patients with anxiety disorder, obsessive–compulsive disorder, and substance or food craving. However, the overall literature features some conflicting results, varied quality of studies,and a lack of consensus on optimal r TMS parameters.Besides, the efficacy of r TMS in patients with medicationresistant symptoms has drawn most attention from clinicians. Here we review multi-site studies and double-blind randomized controlled trials(RCTs) in single sites, as well as meta-analyses of RCTs in the last three years, in order to update evidence on efficacy and the optimal protocol of r TMS in psychiatric disorders, especially for medicationresistant symptoms. | Qian Guo Chunbo Li Jijun Wang | 2017 | Neuroscience Bulletin2017，33，6： | 17 |
| 4 | Meta-analysis of cognitive function in Chinese first-episode schizophrenia: MATRICS Consensus Cognitive Battery (MCCB) profile of impairment显示文摘Background Compromised neurocognition is a core feature of schizophrenia. With increasing studies researching cognitive function of Chinese patients with first-episode schizophrenia (FES) using MATRICS Consensus Cognitive Battery (MCCB), it is not clear about the level and pattern of cognitive impairment among this population. Aim To provide a meta-analysis systematically analysing studies of neurocognitive function using MCCB in Chinese patients with FES. Methods An independent literature search of both Chinese and English databases up to 13 March 2019 was conducted by two reviewers. Standardised mean difference (SMD) was calculated using the random effects model to evaluate the effect size. Results 56 studies (FES=3167, healthy controls (HC)=3017) were included and analysed. No study was rated as 'high quality' according to Strengthening the Reporting of Observational Studies in Epidemiology. Compared with HCs, Chinese patients with FES showed impairment with large effect size in overall cognition (SMD=-1.60,95% Cl -1.82 to -1.38,厂=67%) and all seven cognitive domains, with the SMD ranging from -0.87 to -1.41. In nine MCCB subtests, patients with FES showed significant difference in Symbol Coding (SMD=-1.90), Trail Making Test (TMT)(SMD=-1.36), Continuous Performance Test-Identical Pairs (SMD=-1.33), Hopkins Verbal Learning Test (SMD=-1.24), Brief Visuospatial Memory Test (SMD=-1.18), Mazes (SMD=-1.16), Category Fluency (SMD=-1.01), Spatial Span (SMD=-0.69) and Mayer-Salovey-Caruso Emotional Intelligence Test (SMD=-0.38). Conclusions Our meta-analysis demonstrates that Chinese patients with FES show neurocognitive deficits across all seven MCCB cognitive domains and all nine subtests, particularly in two neurocognitive domains: speed of processing and attention/vigilance, with the least impairment shown in social cognition. Symbol Coding and TMT may be the most sensitive tests to detect cognitive deficit in Chinese patients with FES. | Huijuan Zhang Yao Wang Yuliang Hu Yikang Zhu Tian hong Zhang Jijun Wang Ke Ma Chuan Shi Xin Yu Chunbo Li | 2019 | General Psychiatry2019，32，3： | 13 |
| 5 | Stress Corrosion Cracking of Nitrogen-containing Stainless Steel 316LN in High Temperature Water Environments显示文摘Stress corrosion cracking(SCC) of stainless steels and Ni-based alloys in high temperature water coolant is one of the key problems affecting the safe operation of nuclear power plants(NPPs).The nitrogen-added stainless steel is a kind of possible candidate materials for mitigating SCC since reducing the carbon content and adding nitrogen to offset the loss in strength caused by the decrease in carbon content can mitigate the problem of sensitization.However,the reports of SCC of nitrogen-added stainless steels in high temperature water are few available.The effects of applied potential and sensitization treatment on the SCC of a newly developed nitrogen-containing stainless steel(SS) 316LN in high temperature water doped with chloride at 250 ℃ were studied by using slow strain rate tests(SSRTs).The SSRT results are compared with our data previously published for 316 SS without nitrogen and 304NG SS with nitrogen,and the possible mechanism affecting the SCC behaviors of the studied steels is also discussed based on SSRT and microstucture analysis results.The susceptibility to cracking of 316LN SS normally increases with increasing potential.The susceptibility to SCC of 316LN SS was less than that of 316 SS and 304NG SS.Sensitization treatment at 700 ℃ for 30 h showed little effect on the SCC of 316LN SS and significant effect on the SCC of 316 SS.The predominant cracking mode for the 316LN SS in both annealed state and the state after the sensitization treatment was transgranular.The presented conditions of mitigating stress corrosion cracking are some useful information for the safe use of 316LN SS in NPPs. | YANG Wu LI Guangfu HUANG Chunbo ZHOU Jianjiang LU Zhanpeng | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 9 |
| 6 | Groundwater contributions in water-salt balances of the lakes in the Badain Jaran Desert,China显示文摘Groundwater-fed lakes are essential for the ecology in arid and semiarid regions.As a typical arid region,the Badain Jaran Desert (BJD) is famous in the world for the presence of a large number of groundwater-fed saline lakes among the mega dunes.Based on the up to date geological surveys and observations,this study analyzed the groundwater contributions in water-salt balances of the lakes in the desert.We found different types of springs,including the sublacustrine springs that indicate an upward flow of groundwater under the lakebed.A simplified water balance model was developed to analyze the seasonal variations of water level in the Sumu Barun Jaran Lake,which revealed an approximately steady groundwater discharge in the lake and explained why the amplitude of seasonal changes in lake level is less than 0.5 m.In addition,a salt balance model was developed to evaluate the salt accumulations in the groundwater-fed lakes.The relative salt accumulation time is 800–7,000 years in typical saline lakes,which were estimated from the concentration of Cl-,indicating a long history evolution for the lakes in the BJD.Further researches are recommended to provide comprehensive investigations on the interactions between the lakes and groundwater in the BJD. | GONG Yanping WANG Xusheng HU B Xiao ZHOU Yangxiao HAO Chunbo WAN Li | 2016 | Journal of Arid Land2016，8，5： | 7 |
| 7 | Changes in energy metabolism in the quadriceps femoris after a single bout of acute exhaustive swimming in rats: a 31p-magnetic resonance spectroscopy study显示文摘 | Sun Yingwei Pan Shinong Chen Zhian Zhao Heng Ma Ying Zheng Liqiang Li Qi Deng Chunbo Fu Xihu Lu Zaiming Guo Qiyong | 2014 | Chinese Medical Journal2014，，5： | 5 |
| 8 | Meta-analysis of the relationship of peripheral retinal nerve fiber layer thickness to Alzheimer's disease and mild cognitive impairment显示文摘 | Meijuan WANG Yinbo ZHU Zhongyong SHI Chunbo LI Yuan SHEN | 2015 | 上海精神医学2015，27，5： | 5 |
| 9 | Efficacy and safety of repetitive transcranial magnetic stimulation for generalised anxiety disorder: A metaanalysis显示文摘Background Pharmacological and conventional nonpharmacological treatments are only moderately effective in treatingeneralised anxiety disorder(GAD).Recently,repetitive transcranial magnetic stimulation(rTMS)has attracted interest because of its potential therapeutic value.Aim To investigate the efficacy and safety of rTMS treatment for GAD.Methods Literature studies published in English or Chinese were screened in 10 electronic databases up to 5 December 2018.The included studies'bias risk was assessed using Cochrane risk of bias assessment tool.Meta-analysis was performed to compute the standardised mean difference(SMD)and risk ratio(RR)along with its 95%Cis through using RevMan V.5.3.Heterogeneity was inspected by I2 and the χ2 test.We performed subgroup analysis and meta-regression to investigate heterogeneity.We used funnel plot to assess publication bias.We used the GRADE approach to assess the whole quality of evidence.Results Twenty-one studies,with a total sample size of 1481,were analysed.The risk of bias in most studies included is moderate,the majority of which are lacking of blinding methods of treatment allocation.The treatment had beneficial effects in the rTMS group compared with the control group in mean anxiety score(SMD=-0.68;95%Cl-0.89 to-0.46).None of the 21 studies included here reported severe adverse events.As for dropout rates,there are no statistically significant differences between the two groups(RR 1.14,95%Cl 0.72 to 1.82)or adverse events(RR 0.95,95%Cl 0.77 to 1.18).No particular influence on the heterogeneity of any variable was observed.The risk of publication bias was low.According to the GRADE approach,the evidence levels of primary outcome(treatment effects)and secondary outcomes(acceptability and safety)were rated as‘medium’.Conclusion The use of rTMS combined with medication treatment may have a significant positive anti-anxiety effect on patients with GAD.However,we should interpret the results cautiously due to the relatively high heterogeneity of the meta-analysis.Future high-quality clinical trials are needed to confirm our results. | Huiru Cui Lijuan Jiang Yanyan Wei Wei Li Hui Li Junjuan Zhu Jiaoyan Pang Jijun Wang Chunbo Li | 2019 | General Psychiatry2019，32，5： | 5 |
| 10 | Segregation between the parietal memory network and the default mode network: effects of spatial smoothing and model order in ICA显示文摘A brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent f MRI studies. Though it is anatomically adjacent to and spatially overlaps with the default mode network(DMN), its function has been associated with memory processing, and it has been referred to as the parietal memory network(PMN). Independent component analysis(ICA) is the most common data-driven method used to extract PMN and DMN simultaneously. However,the effects of data preprocessing and parameter determination in ICA on PMN–DMN segregation are completely unknown. Here, we employ three typical algorithms of group ICA to assess how spatial smoothing and model order influence the degree of PMN–DMN segregation. Our findings indicate that PMN and DMN can only be stably separated using a combination of low-level spatial smoothing and high model order across the three ICA algorithms. We thus argue for more considerations on parametric settings for interpreting DMN data. | Yang Hu Jijun Wang Chunbo Li Yin-Shan Wang Zhi Yang Xi-Nian Zuo | 2016 | Science Bulletin2016，61，24： | 4 |
| 11 | Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling显示文摘Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in vitro.The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing.One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating Stat3.Accordantly,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer cells.The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells.Furthermore,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells.Together,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF. | Li Liu Yudong Wu Cheng Zhang Chong Zhou Yining Li Yi Zeng Chunbo Zhang Rong Li Daya Luo Lieliang Wang Long Zhang Shuo Tu Huan Deng Shiwen Luo Ye-Guang Chen Xiangyang Xiong Xiaohua Yan | 2020 | Journal of Molecular Cell Biology2020，12，9： | 4 |
| 12 | Effects of Water Vapor on the Isothermal Combustion Characteristics of Coal Char显示文摘 | WANG Chunbo LI Chao LEI Ming | 2013 | 中国电机工程学报2013，33，32： | 3 |
| 13 | Analysis of the Microstructure and Mechanical Properties during Inertia Friction Welding of the Near-α TA19 Titanium Alloy显示文摘The current research of titanium alloy on friction welding process in the field of aero-engines mainly focuses on the linear friction welding.Compared to the linear friction welding,inertial friction welding of titanium alloy still has important application position in the welding of aero-engine rotating assembly.However,up to now,few reports on inertial friction welding of titanium alloy are found.In this paper,the near-alpha TA19 titanium alloy welded joint was successfully obtained by inertial friction welding(IFW)process.The microstructures and mechanical properties were investigated systematically.Results showed that the refined grains within 15‒20μm and weak texture were found in the weld zone due to dynamic recrystallization caused by high temperature and plastic deformation.The weld zone consisted of acicularα′martensite phase,αp phase and metastableβphase.Most lath-shapedαs andβphase in base metal were transformed into acicular martensiteα′phase and metastableβphase in thermo-mechanically affected zone and heat affected zone.As a result,the microhardness of welded joint gradually decreased from the weld zone to the base metal.Tensile specimens in room temperature and high temperature of 480℃ were all fractured in base metal illustrating that the inertia friction welded TA19 titanium alloy joint owned higher tensile strength compared to the base metal. | Yanquan Wu Chunbo Zhang Jun Zhou Wu Liang Yunlei Li | 2020 | Chinese Journal of Mechanical Engineering2020，33，6： | 3 |
| 14 | Five-year follow-up study of multi-domain cognitive training for healthy elderly community members显示文摘 | Wei FENG Chunbo LI You CHEN Yan CHENG Wenyuan WU | 2014 | 上海精神医学2014，26，1： | 3 |
| 15 | Altered heartbeat perception sensitivity associated with brain structural alterations in generalised anxiety disorder显示文摘Background Palpitation is a common complaint in generalised anxiety disorder(GAD).Brain imaging studies have Investigated the neural mechanism of heartbeat perception in healthy volunteers.This study explored the neuroanatomical differences of altered heartbeat perception in patients with GAD using structural MRI.Aims Based on the strong somatic-interoceptive symptoms in GAD,we explored the regional structural brain abnormalities involved in heartbeat perception in patients with GAD.Methods This study was applied to the a priori regions using neuroanatomical theories of heartbeat perception,including the insula,anterior cingulate cortex,supplementary motor area and prefrontal cortex.A total of 19 patients with GAD and 19 healthy control subjects were enrolled.We used the FMRIB Software Library voxel-based morphometry software for estimating the grey matter volume of these regions of interest and analysed the correlation between heartbeat perception sensitivity and the volume of abnormal grey matter.Results Patients with GAD showed a significantly decreased volume of grey matter in their left medial prefrontal cortex,right orbital frontal cortex and anterior cingulate cortex.The grey matter volume of the left medial prefrontal cortex negatively correlated with heartbeat perception sensitivity in patients with GAD.Conclusions It should be the first study that shows heartbeat perception is associated with brain structure in GAD.Our findings suggest that the frontal region may play an important role in aberrant heartbeat perception processing in patients with GAD,and this may be an underlying mechanism resulting in the abnormal cardiovascular complaints in GAD.This is hypothesised as a'top-down'deficiency,especially in the medial prefrontal cortex.This will provide the foundation for a more targeted region for neuromodulation intervention in the future. | Hui Li Bin Zhang Qiang Hu Lanlan Zhang Yi Jin Jijun Wang Huiru Cui Jiaoyan Pang Chunbo Li | 2020 | General Psychiatry2020，33，1： | 2 |
| 16 | 3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway显示文摘Traditional Chinese medicine(TCM)has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers.3-epi-bufotalin is an active ingredient of TCM“Chanpi”with anti-tumor potential.However,the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well disclosed.The present study demonstrated that 3-epi-bufotalin could reduce viability,trigger apoptosis,and block the cell cycle at the G2/M stage in colorectal cancer cell lines HT29,RKO,and COLO205 in vitro.Moreover,3-epi-bufotalin inhibited the JAK1/STAT3 signaling pathway.These results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells. | SANHUA LI QINGHONG KONG XIAOKE ZHANG XINTING ZHU CHUNBO YU CHANGYAN YU NIAN JIANG JING HUI LINGJIE MENG YUN LIU | 2022 | BIOCELL2022，46，11： | 2 |
| 17 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 18 | Effect ofCNTs on direct oxidation of cyclohexene catalyzed by ruthe-nium diaminodiphosphine complex显示文摘 | Li Chunbo Pan Weixiong Wong Waikwok | 2003 | J Mol Catal A:Chem2003，193，12： | 1 |
| 19 | Tanshinone IIA reduces the risk of Alzheimer’s disease by inhibitingiNOS, MMP?2 and NF?κBp65 transcription and translation in the temporal lobes ofrat models of Alzheimer’s disease显示文摘 | Ping Jiang Chunbo Li Zhenghua Xiang Binghua Jiao | 2014 | Molecular Medicine Reports2014，，： | 1 |
| 20 | Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis显示文摘 | Stefan Leucht Caroline Corves Dieter Arbter Rolf R Engel Chunbo Li John M Davis | 2009 | The Lancet . 2009 (9657)2009，，9657： | 1 |
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