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| 1 | Failure mechanism and coupled static-dynamic loading theory in deep hard rock mining: A review显示文摘Rock failure phenomena,such as rockburst,slabbing(or spalling) and zonal disintegration,related to deep underground excavation of hard rocks are frequently reported and pose a great threat to deep mining.Currently,the explanation for these failure phenomena using existing dynamic or static rock mechanics theory is not straightforward.In this study,new theory and testing method for deep underground rock mass under coupled static-dynamic loading are introduced.Two types of coupled loading modes,i.e.'critical static stress + slight disturbance' and 'elastic static stress + impact disturbance',are proposed,and associated test devices are developed.Rockburst phenomena of hard rocks under coupled static-dynamic loading are successfully reproduced in the laboratory,and the rockburst mechanism and related criteria are demonstrated.The results of true triaxial unloading compression tests on granite and red sandstone indicate that the unloading can induce slabbing when the confining pressure exceeds a certain threshold,and the slabbing failure strength is lower than the shear failure strength according to the conventional Mohr-Column criterion.Numerical results indicate that the rock unloading failure response under different in situ stresses and unloading rates can be characterized by an equivalent strain energy density.In addition,we present a new microseismic source location method without premeasuring the sound wave velocity in rock mass,which can efficiently and accurately locate the rock failure in hard rock mines.Also,a new idea for deep hard rock mining using a non-explosive continuous mining method is briefly introduced. | Xibing Li Fengqiang Gong Ming Tao Longjun Dong Kun Du Chunde Ma Zilong Zhou Tubing Yin | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，4： | 68 |
| 2 | Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients显示文摘A hallmark of systemic lupus erythematosus(SLE)is the breaking of B-cell tolerance with the generation of high-affinity autoantibodies;however,the antibody-independent features of the B-cell compartment in SLE are less understood.In this study,we performed an extensive examination of B-cell subsets and their proinflammatory properties in a Chinese cohort of new-onset SLE patients.We observed that SLE patients exhibited an increased frequency of transitional B cells compared with healthy donors and rheumatoid arthritis patients.Plasma from SLE patients potently promoted the survival of transitional B cells in a type I IFN-dependent manner,which can be recapitulated by direct IFN-αtreatment.Furthermore,the effect of IFN-αon enhanced survival of transitional B cells was associated with NF-κB pathway activation and reduced expression of the pro-apoptotic molecule Bax.Transitional B cells from SLE patients harbored a higher capacity to produce proinflammatory cytokine IL-6,which was also linked to the overactivated type I IFN pathway.In addition,the frequency of IL-6-producing transitional B cells was positively correlated with disease activity in SLE patients,and these cells were significantly reduced after short-term standard therapies.Thus,the current study provides a direct link between type I IFN pathway overactivation and the abnormally high frequency and proinflammatory properties of transitional B cells in active SLE patients,which contributes to the understanding of the roles of type I IFNs and B cells in the pathogenesis of SLE. | Mei Liu Qiang Guo Chunmei Wu Delphine Sterlin Shyamal Goswami Ying Zhang Teng Li Chunde Bao Nan Shen Qiong Fu Xiaoming Zhang | 2019 | Cellular & Molecular Immunology2019，16，4： | 9 |
| 3 | Mechanical properties of rock under coupled static-dynamic loads显示文摘Rock drilling machine,INSTRON testing system,and SHPB device are updated to investigate the characteristics of rocks at great depth,with high loads from overburden,tectonic stresses and dynamic impacts due to blasting and boring.It is verified that these testing systems can be used to study the mechanical properties of rock material under coupled static and dynamic loading condition and give useful guidance for the deep mining and underground cavern excavation.Various tests to determine the rock strength,fragmentation behavior,and energy absorption were conducted using the updated testing systems.It is shown that under coupled static-dynamic loads,if the axial prestress is lower than its elastic limit,the rock strength is higher than the individual static or dynamic strength.At the same axial prestress,rock strength under coupled loads rises with the increasing strain rates.Under coupled static and dynamic loads,rock is observed to fail with tensile mode.While shear failure may exist if axial prestress is high enough.In addition,it is shown that the percentage of small particles increases with the increasing axial prestress and impact load based on the analysis of the particle-size distribution of fragments.It is also suggested that the energy absorption ratio of a specimen varies with coupled loads,and the maximum energy absorption ratio for a rock can be obtained with an appropriate combination of static and dynamic loads. | Xibing Li Zilong Zhou Fujun Zhao Yujun Zuo Chunde Ma Zhouyuan Ye Liang Hong | 2009 | Journal of Rock Mechanics and Geotechnical Engineering2009，1，1： | 8 |
| 4 | Effect of surgical factors on the augmentation of cementinjectable cannulated pedicle screw fixation by a novel calcium phosphate-based nanocomposite显示文摘Bone cement-augmented pedicle screw system demonstrates great efficacy in spinal disease treatments. However, the intrinsic drawbacks associated with clinically used polymethylmethacrylate (PMMA) cement demands for new bone cement formulations. On the basis of our previous studies, a novel injectable and biodegradable calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was systematically evaluated for its surgical feasibility and biomechanical performance by simulated and animal osteoporotic bone models, and the results were compared with those of clinical PMMA cement. ASTM-standard solid foam and open-cell foam models and decalcified sheep vertebra models were employed to evaluate the augmentation effects of CPN on bone tissue and on the cement-injected cannulated pedicle screws (CICPs) placed in osteoporotic bone. Surgical factors in CICPs application, such as injection force, tapping technique, screw diameter, and pedicle screw loosening scenarios, were studied in comparison with those in PMMA. When directly injected to the solid foam model, CPN revealed an identical augmentation effect to that of PMMA, as shown by the similar compressive strengths (0.73 ± 0.04 MPa for CPN group vs. 0.79 ± 0.02 MPa for PMMA group). The average injection force of CPN at approximately 40-50 N was higher than that of PMMA at approximately 20 N. Although both values are acceptable to surgeons, CPN revealed a more consistent injection force pattern than did PMMA. The dispersing and anti-pullout ability of CPN were not affected by the surgical factors of tapping technique and screw diameter. The axial pullout strength of CPN evaluated by the decalcified sheep vertebra model revealed a similar augmentation level as that of PMMA (1351.6 ± 324.2 N for CPN vs. 1459.7 ± 304.4 N for PMMA). The promising results of CPN clearly suggest its potential for replacing PMMA in CICPs augmentation application and the benefits of further study and development for clinical uses. | Haolin Sun Chun Liu Shunlun Chen Yanjie Bai Huilin Yang Chunde Li Lei Yang | 2019 | Frontiers of Medicine2019，13，5： | 2 |
| 5 | Study on combustion of gasoline/MTBE in laminar flame with synchrotron radiation 显示文摘 | Yao Chunde Li Jing Li Qi | 2007 | Chemospere2007，67，10： | 1 |
| 6 | Study on combustion of gasoline/MTBE in laminar flame with synchrotron radiation显示文摘 | Yao Chunde Li Jing Li Qi | 2007 | Chemosphere2007，67，10： | 1 |
| 7 | Recompression in new levels after percutaneous vertebroplasty and kyphoplasty compared with conservative treatment显示文摘 | Xiaodong Yi Hailin Lu Fei Tian Yu Wang Chunde Li Hong Liu Xianyi Liu Hong Li | 2014 | Archives of Orthopaedic and Trauma Surgery2014，，1： | 1 |
| 8 | Improvement in production traits by mass spawning type crossbreeding in bay scallops 显示文摘 | Wang Chunde Li Zhaoxia | 2010 | Aquacul- ture2010，299，： | 1 |
| 9 | Anti-dumping Shock and the Productivity Response of Chinese Industries显示文摘 | Chunding Li | 2017 | China & World Economy2017，25，2： | 1 |
| 10 | China and the Trans‐Pacific Partnership: A Numerical Simulation Assessment of the Effects Involved显示文摘 | Chunding Li John Whalley | 2014 | World Econ2014，，2： | 1 |
| 11 | Diclofenac epol- amine medicated plaster in the treatment of minor soft tis- sue injuries : a multicenter randomized controlled trial 显示文摘 | Li Chunde Frangione V Rovati S | 2013 | Curr Med Res Opin2013，29，9： | 1 |
| 12 | High-speed turning force measurement and analysis 显示文摘 | Shi Li Sun Yulong Jia Chunde | 2013 | Mechanical processing technolo- gy and equipment2013，，10： | 1 |
| 13 | Clinical outcomes of adult medulloblastoma:A retrospective analysis at a single institute显示文摘Objectives: Adult medulloblastoma is a rare tumor, and few retrospective studies on medulloblastoma have been published to date. A standard treatment regimen has not yet been established. Accordingly, this study was designed to determine the treatment outcomes and prognostic factors for patients with adult medulloblastoma.Methods: We retrospectively reviewed all cases of adult medulloblastoma at the Beijing Tiantan Hospital between 2004 and 2007. There were 33 patients in total. Tumor removal followed by radiotherapy was performed in all patients. Five patients received maintenance chemotherapy after radiotherapy. Statistical analysis was performed using the log‐rank test, Kaplan–Meier method, and Cox regression analysis. Results: The median follow‐up period was 73 months. The 5‐year progression‐free survival(PFS) and overall survival(OS) rates were 45.5% ± 8.7% and 51.5% ± 8.7%,respectively. Recurrence or progression was observed in 21 patients, and 14 patients were still alive. Tumor location at the midline with infiltration to the floor of the fourth ventricle was associated with the worst PFS and OS(P = 0.032). Hemispheric desmoplastic/nodular medulloblastomas(DNMBs) were associated with a better outcome than midline DNMB. The average‐risk group tended to have a better 5‐year PFS rate than the high‐risk group(P = 0.065). Conclusions: Tumor location is an important prognostic marker for adulthood MB.We propose a molecular and clinical staging system should be established for adulthood MB. Further prospective clinical trials should be performed to draw a conclusion. | Tao Jiang Jin Zhu Jing Dong Junmei Wang Jiang Du Chunde Li Yuqi Zhang | 2015 | Translational Neuroscience and Clinics2015，1，1： | 0 |
| 14 | China and the Reform of International Trade Governance System显示文摘The 21st century has carried the international trade governance system into a period of accelerated reshaping.The reform has been fueled by many factors including the requirement of the in-depth development of global value chains for cross-border institutional coordination,the requirement of the form of digital economy for new digital rules,and the requirement of the dominant countries under the traditional international trade governance system for the maintenance of their own interests.The reform of international trade governance system has driven China to adjust itself to external pressures while creating opportunities for the country to deepen the reform and join international trade governance.China as a beneficiary and firm supporter of economic globalization has rapidly grown from a marginal participator in economic globalization into a builder and contributor of the governance of the international trading system.It plays an active part in the reform of international trading system and the construction of a community of shared future for mankind by means of the making of rules,the reshaping of rules,the adjustment of rules,and the adaptation to rules.In addition,the critical measures for China to cope with the changes of globalization also consist in its deepened domestic reform,proactive opening-up,facilitated alignment with domestic and international rules,and an institutional environment suitable for the new situation of a'dual circulation'development pattern. | Dong Yan Li Chunding | 2021 | Social Sciences in China2021，42，3： | 0 |
| 15 | Mechanical Behaviors of Silt Rock Subjected to Coupling Static and Impact Loads显示文摘Experiments of silt rock subjected to coupling loads were carried out on tailormade equipment. With a constant dynamic load, the behaviors of eight sets of siltite specimens were investigated with different axial static loads. The experimental results show that the modulus of the specimens under coupling loads increases at first and then decreases with the increase of axial static pressure. The failure model of the specimens also varies. Keeping the dynamic load constant, when the axial static pressure is low, the specimen breaks in two simply. With the increase of axial static pressure, the cone-shaped fragment appeares. When the axial static pressure reaches 90% of the static strength of rock, the specimen smashes into amount of small fragments. | ZHOU Zilong LI Xibing HONG Liang MA Chunde | 2006 | Transactions of Tianjin University2006，12，B09： | 0 |
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