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| 1 | The evolution and functional diversification of animal microRNA genes显示文摘microRNAs (miRNAs ) 是 22 核苷酸(nt ) 的一个丰富的班在更高真核细胞的染色体是弥漫的规章的 RNA。以便充分在染色体理解他们的突起,阐明是必要的能多样化 miRNA 活动的分子的机制。在这评论,我们描述一些允许新奇 miRNA 功能出现的许多策略,与 miRNA 基因怎么在动物演变的特别强调。这些机制在他们的顺序包括变化,处理,或表示模式;miRNA 的获得 * 功能或 antisense 处理;并且 de novo 基因出生。miRNAs 的设备和通用性位于下面多半演变并且变化他们怎么成为了更高的染色体的主导的成分。 | Na Liu Katsutomo Okamura David M Tyler Michael D Phillips Wei-Jen Chung Eric C Lai | 2008 | Cell Research2008，18，10： | 17 |
| 2 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 3 | Low-drying-shrinkage concrete containing carbon fibers 显示文摘 | Chen P W Chung D D L | 1996 | Composites Part B1996，27，34： | 2 |
| 4 | Carbon fiber reinforced concrete as an intrinsically smart concrete for damage assessment during static and dynamic loading 显示文摘 | Chen P W Chung D D L | 1996 | ACI Materials Journal1996，93，4： | 2 |
| 5 | Normal maturing distal tibia and fibula: changes with age at MR imaging显示文摘 | Chung T Jaramillo D | 1995 | Radiology1995，194，1： | 2 |
| 6 | Cancer chemopreventive activity and bioavailability of tea and tea polyphenols显示文摘 | Joshua D Lambert Chung S Yang | 2002 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2002，，： | 2 |
| 7 | Superplasticity in Thin Magnesium Alloy Sheet and Detormation Mechanism Maps for Magnesium Alloys at Elevated Temperatures显示文摘 | Kim W J Chung S W Kum D | 2001 | Acta Mater2001，，49： | 2 |
| 8 | Synthesis of Eu2 + -activated yttrium oxysulfide red phosphor by flux fusion method 显示文摘 | CHUNG L L JENG G D BI S C | 2001 | Material Chemistry and Physics2001，71，： | 2 |
| 9 | CsBi4Te6: A high-performance thermoelectric material for low-temperature applications 显示文摘 | Chung D Y Hogan Tim Brazis Paul | 2000 | Science2000，1，1287： | 2 |
| 10 | Carbon fiber-rein- forced concrete for traffic monitoring and weighing in motion显示文摘 | Zeng-Qiang Shi Chung D D L | 1999 | Cement and Concrete Research1999，29，： | 1 |
| 11 | 显示文摘 | Choi W B Chung D S Kang J H | 1999 | Applied Physics Letters1999，75，20： | 1 |
| 12 | e myc Expression, keep the noise down显示文摘 | Chung H J Levens D | 2005 | Mol Cells2005，20，2： | 1 |
| 13 | Stability of Jensen Equations in the Space of Generalized Functions显示文摘 | Li L Chung J Kim D | 2004 | J Math Anal Appl2004，299，： | 1 |
| 14 | Natural herbicide potential of alfalfa residues on selected weed species显示文摘 | Chung I M Miller D A | 1995 | Agron J1995，87，： | 1 |
| 15 | C-reactive protein elevation in patients with atrial arrhythmias:inflammatory mechanisms and persistence of atrial fibrillation显示文摘 | Chung MK Martin DO Spreeher D | 2001 | Circulation2001，104，24： | 1 |
| 16 | Improving both bond strength and corrosion resistance of steel rebar in concrete by water immersion or sand blasting of rebar显示文摘 | Hou Jiangyuan Fu Xuli Chung D D L | 1997 | Cement and Concrete Research1997，27，5： | 1 |
| 17 | Inter-and Intra-day Liquidity Patterns on the Stock Exchange of Hong Kong显示文摘 | BROCKMAN P CHUNG D Y | 1998 | Journal of International Financial and Markets Institutions and Money1998，8，3： | 1 |
| 18 | C-reactive protein eleva- tion in patients with atrial arrhythmias:inflammatory mechanisms and persistence of atrial fibrillation 显示文摘 | Chung MK Martin DO Spreeher D | 2001 | Circulation2001，104，24： | 1 |
| 19 | Stool DNA analysis for the de- tection and follow-up of colorectal cancer (CRC) and advanced ade- nomas (AA) : sensitivity in a p rospeetive series 显示文摘 | Syngal S Chung D Willett C | 2002 | Am J Gastro- enterol2002，，： | 1 |
| 20 | On the Iterative Decoding of Sparse Quantum Codes显示文摘 | Poulin D Chung Yeojin | 2008 | International Journal of Quantum Information and computation2008，8，10： | 1 |
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