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| 1 | The DNA Damage Response: Making It Safe to Play with Knives显示文摘 | Alberto Ciccia Stephen J. Elledge | 2010 | Molecular Cell2010，，2： | 3 |
| 2 | Expansion of intestinal CD4-CD25 (high) Treg cells in patients with ankylosing spondylitis: a putative role for interleukin 10 in preventing intestinal Th17 response显示文摘 | Ciccia F Accardo-Palumbo A Giardina A | 2010 | Arthritis Rheuma- tism2010，62，： | 1 |
| 3 | The DNA damage response: making it safe to play with knives显示文摘 | Ciccia A Elledge SJ | 2010 | Mol Cell2010，40，2： | 1 |
| 4 | A Th1 but not a Th17 response is present in the gastrointestinal involvement of Behcet's disease显示文摘 | Ferrante A Ciccia F Principato A | 2010 | Clinical and experimental rheumatology2010，28，460： | 1 |
| 5 | Expansion of intestinal CD4+CD25(high) Treg cells in patients with ankylosing spondylitis: a putative role for interleukin-10 in preventing intestinal Th17 response显示文摘 | Ciccia F Accardo-Palumbo A Giardina A | 2010 | Arthritis Rheum2010，62，12： | 1 |
| 6 | The DNA damage response:making it safe to play with knives显示文摘 | Ciccia A Elledge SJ | 2010 | Mol Cell2010，40，2： | 1 |
| 7 | Adalimumab efficacy in enteropathic spondyloarthritis: A 12-mo observational multidisciplinary study显示文摘AIM To report adalimumab(Ada) efficacy on articulargastrointestinal disease and health-related quality of life(HRQo L) in patients with enteropathic spondyloarthritis(ES).METHODS A cohort of 52 patients with ES was evaluated in the departments of gastroenterology and internal medicine. At baseline, all patients underwent assessment by an integrated gastro-rheumatologic evaluation of articular and gastrointestinal activity, as well patient reported outcomes(PROs) of the HRQo L questionnaires. After this integrated evaluation and following a specific working flowchart, the Ada anti-tumor necrosis factor(TNF)-inhibitor was assigned to a cohort of 30 patients and its clinical efficacy was evaluated at baseline and after 6-mo and 12-mo treatment by the following tests:(1) Ankylosing Spondylitis Disease Activity ScoreC-Reactive Protein(ASDAS-CRP); Bath Ankylosing Spondylitis Disease Activity Index(BASDAI), Bath Ankylosing Spondylitis Functional Index(BASFI) and Bath Ankylosing Spondylitis Metrology Index(BASMI) for articular activity;(2) Inflammatory Bowel Disease Questionnaire(IBDQ), Crohn's Disease Activity Index(CDAI) and partial Mayo(p Mayo) score for gastrointestinal symptoms and activity; and(3) Health Assessment Questionnaire(HAQ), Patient Global Assessment(PGA) and Short Form-36 health survey(SF-36) questionnaires for PROs of the HRQo L.RESULTS Integrated evaluation and management of the patients affected by ES, carried out simultaneously by a gastroenterologist and a rheumatologist, allowed clinicians to choose the optimal therapeutic strategy. In a cohort of 30 ES patients affected by active articular and gastrointestinal disease, or axial active articular inflammation, Ada led to fast and sustained improvement of both articular and gastrointestinal disease activities. In fact, all the clinimetric evaluation tests exploring articular or gastrointestinal activity, as well as all the HRQo L scores, showed a significant improvement having been achieved at the earliest(6-mo) assessment. This important clinical improvement was maintained at the 12-mo follow-up. Importantly, global and gastrointestinal quality of life significantly correlated with articular disease activity, providing evidence to support that the integrated evaluation is the best option to manage patients with ES.CONCLUSION Ada treatment, upon multidisciplinary(gastrorheumatologic) evaluation, significantly improves both articular and gastrointestinal inflammation, thereby improving the HRQo L in patients affected by ES. | Michele Maria Luchetti Devis Benfaremo Francesco Ciccia Laura Bolognini Monia Ciferri Alessia Farinelli Matteo Rossini Piergiorgio Mosca Giovanni Triolo Armando Gabrielli | 2017 | World Journal of Gastroenterology2017，23，39： | 1 |
| 8 | Antioxidant and Prooxidant Activities in Aqueous Extracts of Argentine Plants显示文摘 | C. Desmarchelier M.J. Novoa Bermudez J. Coussio G. Ciccia A. Boveris | 1997 | Pharmaceutical Biology1997，，2： | 1 |
| 9 | Identification of FAAP24,a Fanconi anemia core complex protein that interacts with FANCM显示文摘 | Ciccia A Ling C Coulthard R | 2007 | Mol Cell2007，25，3： | 1 |
| 10 | Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation显示文摘 | Ciccia F Accardo-Palumbo A Rizzo A | 2014 | Ann Rheum Dis2014，73，15： | 1 |
| 11 | Expression of interleukin-32 in the inflamed arteries of patients with giant cell arteritis 显示文摘 | Ciccia F Alessandro R Rizzo A | 2011 | Arthritis Rheum2011，63，7： | 1 |
| 12 | Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis显示文摘 | Ciccia F Guggino G Rizzo A | 2015 | Rheumatology (Oxford)2015，54，12： | 1 |
| 13 | Potential involvement of IL- 22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjogren's syndrome显示文摘 | Ciccia F Guggino G Rizzo A | 2012 | Ann Rheum Dis2012，71，2： | 1 |
| 14 | Intestinal CD4(+)CD25(high)regulatory T cells are expanded in ankylosingspondylitis patients:A putative role for IL-10 in preventing intestinal Th17 response显示文摘 | Ciccia F Accardo-Palumbo A Giardina A | 2010 | Arthritis Rheum2010，，62： | 1 |
| 15 | Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondyl~tis and subclinical gut inflammation显示文摘 | Ciccia F Accardo-Palumbo A Rizzo A | 2014 | Ann Rheum Dis2014，73，8： | 1 |
| 16 | Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/ cyclosome substrate显示文摘 | EMANUELE M J CICCIA A ELlA A E | 2011 | Proc Natl Acad Sci U S A2011，108，24： | 1 |
| 17 | IL-34 is overexpressed in the inflamed salivary glands of patients with Sjogreng syndrome and is associated with the local expansion of pro-inflammatory CD14 (bright) CD16 ( + ) monoeytes 显示文摘 | Ciccia F Alessandro R Rodolieo V | 2013 | Rheumatology2013，52，6： | 1 |
| 18 | Overexpression of intedeukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis显示文摘 | Ciccia F Bombardieri M Principato A | 2009 | Arthritis Rheum2009，60，4： | 1 |
| 19 | Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treat ment of recurrent fetal loss associated with antiphopholipid antibodies显示文摘 | Triolo G Ferrante A Ciccia F | 2003 | Arthritis Rheum2003，48，3： | 1 |
| 20 | Inter- leukin-22 and interleukin-22-produeing NKp44 ~ natural killer cells in subclinical gut inflammation in ankylosing spondylitis显示文摘 | Ciccia F Accardo-Palumbo A Alessandro R~ | 2012 | Arthritis Rheum2012，64，6： | 1 |
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