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| 1 | The human TTAGGG repeat factors I and 2 bind to a subsetof interstitial telomeric sequences and satellite repeats显示文摘 | Thomas Simonet Laure-Emmanuelle Zaragosi Claude Philippe Kevin Lebrigand Cldmentine Schouteden Adeline Augereau Serge Bauwens Jing Ye Marco Santagostino Elena Giulotto Frederique Magdinier Beatrice Horard Pascal Barbry Rainer Waldmann Eric Gilson | 2011 | Cell Research2011，21，7： | 7 |
| 2 | Rabeprazole test for the diagnosis of gastro-oesophageal reflux disease: Results of a study in a primary care setting显示文摘瞄准:为了决定病人的 rabeprazole 测试的诊断价值,由全科医生看。方法:有 GERD 暗示的症状的 83 个病人被全科医生在这个多中心注册,使随机化并且双窗帘学习。所有病人收到了 rabeprazole (20 mg 出价) 或安慰剂一个星期。GERD 的诊断在内视镜检查法或反常食道的 24-h pH 测试在粘膜裂缝的存在上被建立。如果病人们报导至少,“ 7 点 Likert 上的症状的清楚的改进”可伸缩,测试被认为阳性。结果:为 rabeprazole 和安慰剂的测试的敏感分别地是 83% 和 40% 。相应特性,积极、否定的预兆的价值是 45% 和 67% , 71% 和 71% ,和 62% 和 35% 分别地。操作特征(巨鸟) 分析的接收装置证实最好差别对待截止对应于对“清楚的改进”的描述。结论:禁止者(PPI ) 测试的质子泵的差的特性不支持如此的一条途径在一个主要照顾背景建立 GERD 的诊断。 | Stanislas Bruley des Varannes Sylvie Sacher-Huvelin Fabienne Vavasseur Claude Masliah Marc Le Rhun Philippe Aygalenq Sylvie Bonnot-Marlier Yves Lequeux Jean Paul Galmiche | 2006 | World Journal of Gastroenterology2006，12，16： | 4 |
| 3 | Wnt signaling and hepatocarcinogenesis: molecular targets for the development of innovative anticancer drugs显示文摘 | Floriane Pez Ana?s Lopez Miran Kim Jack R. Wands Claude Caron de Fromentel Philippe Merle | 2013 | Journal of Hepatology2013，，： | 3 |
| 4 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 5 | Hyper-bent functions and cyclic codes显示文摘 | Claude Carlet Philippe Gaborit | 2005 | Journal of Combinatorial Theory Series A2005，，3： | 2 |
| 6 | Mass tuansfer,clearanceand plasma concentration of procalcitonin during continuousvenovenous hemofiltration in patients with septic shock andacute oliguric renal failure显示文摘 | Claude L Philippe C Olivier G | 2003 | Critical Care2003，6，7： | 1 |
| 7 | Malignant female adnexal tumor of probable wolffian origin relapsing after pregnancy显示文摘 | David Atallah Roman Rouzier Ioannis Voutsadakis Claude Sader-Ghorra Joseph Azoury Sophie Camatte Philippe Morice Pierre Duvillard | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 8 | Procalcitonin:a new marker of inflammation in haemodialysis patients?显示文摘 | Claude L Philippe C Yahsou D | 2001 | Nephrol Dial Transplant2001，16，5： | 1 |
| 9 | Insulin resistance is associated with a higher risk of hepatocellular carcinoma in cirrhotic HIV/HCV-co-infected patients: Results from ANRS CO13 HEPAVIH显示文摘 | Dominique Salmon Firouzé Bani-Sadr Marc-Arthur Loko Hind Stitou Anne Gervais Jacques Durant Eric Rosenthal Yann Quertainmont Karl Barange Daniel Vittecoq Michka Shoai-Tehrani Muriel Alvarez Maria Winnock Jean Claude Trinchet Fran?ois Dabis Philippe Sogni | 2011 | Journal of Hepatology2011，，4： | 1 |
| 10 | Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats显示文摘 | Yannick Béjot Anne Prigent-Tessier Claire Cachia Maurice Giroud Claude Mossiat Nathalie Bertrand Philippe Garnier Christine Marie | 2010 | Neurochemistry International2010，，1： | 1 |
| 11 | Aerosol Polarized Phase Function and Singlescattering Albedo Retrieved form Ground-based Measurements 显示文摘 | Li Z Q Philippe Goloub Claude Devaux | 2004 | Atmospheric Research2004，71，： | 1 |
| 12 | Sorghum phosphoenolpyruvate carboxylase gene family: structure, function and molecular evolution显示文摘 | Lo?c Lepiniec Eliane Keryer Herve Philippe Pierre Gadal Claude Crétin | 1993 | Plant Molecular Biology1993，，3： | 1 |
| 13 | Constraint propagation and decomposition techniques for highly disjunctive and highly cumulative project scheduling problems显示文摘 | PHILIPPE B CLAUDE LE P | 2000 | Constraints2000，5，12： | 1 |
| 14 | Aortic Wrapping for Stanford Type A Acute Aortic Dissection: Short and Midterm Outcome显示文摘 | Pierre Demondion Ramzi Ramadan Alexandre Azmoun Fran?ois Raoux Claude Angel Rémi Nottin Philippe Deleuze | 2013 | The Annals of Thoracic Surgery2013，，： | 1 |
| 15 | Lymphatic Targeting of Polymeric Nanoparticles After Intraperitoneal Administration in Rats显示文摘 | Philippe Maincent Pierre Thouvenot Claude Amicabile Maurice Hoffman J?rg Kreuter Patrick Couvreur Jean Philippe Devissaguet | 1992 | Pharmaceutical Research1992，，12： | 1 |
| 16 | Mechanical thrombectomy in patients with deep venous thrombosis显示文摘 | Maxence Delomez Jean-Paul Beregi M.D. Serge Willoteaux Jean-Jacques Bauchart Bertrand Janne d’Othée Philippe Asseman Nessim Perez Claude Théry | 2001 | Cardiovascular and Interventional Radiology2001，，1： | 1 |
| 17 | Different oxygen redox participation for bulk and surface: A possible global explanation for the cycling mechanism of Li 1.20 Mn 0.54 Co 0.13 Ni 0.13 O 2显示文摘 | Hideyuki Koga Laurence Croguennec Michel Ménétrier Philippe Mannessiez Fran?ois Weill Claude Delmas | 2013 | Journal of Power Sources2013，，： | 1 |
| 18 | Impact of the History of Congestive Heart Failure on the Utility of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure: Results from the Breathing Not Properly Multinational Study显示文摘 | Adam Strunk Vikas Bhalla Paul Clopton Richard M. Nowak James McCord Judd E. Hollander Philippe Duc Alan B. Storrow William T. Abraham Alan H.B. Wu Gabriel Steg Alberto Perez Radmila Kazanegra Howard C. Herrmann Marie Claude Aumont Peter A. McCullough Alan | 2006 | The American Journal of Medicine2006，，1： | 1 |
| 19 | cDNA nucleotide sequence and expression of a maize cytoplasmic ribosomal protein S13 gene显示文摘 | Philippe Joanin Claude Gigot Gabriel Philipps | 1993 | Plant Molecular Biology1993，，4： | 1 |
| 20 | Room-temperature Mirror Prepatation Using Sol-gel Chemistry and Laminar-flow Coating Technique显示文摘 | Philippe Belleville Claude Bonnin Jean-Jacques Priotton | 2000 | Journal of Sol-gel Science and Technology2000，19，： | 1 |
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