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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Structural and functional differences in various divisions of the rabbit colon 显示文摘 | Snipes RL Clauss W Weber A | 1982 | Cell Tissue Res1982，225，2： | 1 |
| 3 | Drug induced arousal from the permanent vegetative state 显示文摘 | Clauss R Nel W | 2006 | Neurorehabilitation2006，21，1： | 1 |
| 4 | Custom cerium oxide nanoparticles protect against a rice radical mediated autoimmune degenerative disease in the brain 显示文摘 | Heckman K L DeCoteau W Estevez A Reed K J Costanzo W Sanford D Leiter J C Clauss J Knapp K Gomez C Mullen P Rathbun E Prime K Marini J Patchefsky J Patchefsky A S Hailstone R K Erli- chman J S | 2013 | ACS Nano2013，7，10： | 1 |
| 5 | Iohexol in excretory urgraphy显示文摘 | Schrott KM Behrends B Clauss W | 1986 | Fortschr Med1986，104，： | 1 |
| 6 | Correlation of structure,mobility,and morphological information in heterogeneous polymer materials by two-dimensional wideline-separation NMR spectroscopy\显示文摘 | Schmidt-Rohr K Clauss J Spiess H W | 1992 | Macromolecules1992，25，12： | 1 |
| 7 | Determination of domain sizes in heterogeneous polymers by solid-state NMR显示文摘 | Clauss J Schmidt-Rohr K Spiess H W | 1993 | Acta Polym1993，44，1： | 1 |
| 8 | Self-optimizing and adaptive digital signal processor based algorithms in scanning tunneling microscopy显示文摘 | Scheuring J Clauss W Kern D P | 1998 | Review of Scientific Instruments1998，69，： | 1 |
| 9 | Use of artificially applied n-alkanes as markers for the estimation of digestibility, food selection and intake in pigeons(Columba livia)显示文摘 | Hatt J M Mayes R W Clauss M | 2001 | Animal Feed Science and Technology2001，94，12： | 1 |
| 10 | Correlation of structure, mobility, and morphological information in heterogeneous polymer materials by two-dimensional wideline-separation NMR spectroscopy显示文摘 | Schmidt-Rohr K Clauss J Spiess H W | 1992 | Macromole cules1992，25，12： | 1 |
| 11 | Use of artificially applied n-alkanes as markers for the estimation of digestibility, food selection and intake in pigeons (Columba livia) 显示文摘 | Hatt J M Mayes R W Clauss M | 2001 | Animal Feed Science and Technology2001，94，： | 1 |
| 12 | Scanning tunneling microscopy on self-assembled calix resorcinarene monolayer adsorbates on Au显示文摘 | Raible S Weiss T Clauss W | 2000 | Materials Science & Processing2000，70，6： | 1 |
| 13 | Palladium-Nickel-Elektrolyt mit geringem Ammoniumgehalt fur die Hochgeschwindigkeitsabscheidung von Kontaktelementen - Ein Jahr industrielle praxis 显示文摘 | ZHANG W CLAUSS M GUEBDY J | 2009 | Galvanotechnik2009，100，5： | 1 |
| 14 | Coordinate expression of vascular endothelial growth factor receptor 1 (fit- 1)and its ligand sug-gests a paracrine regulation of murine vascular development显示文摘 | Breier G Clauss M Risau W | 1995 | Dev Dyn1995，204，3： | 1 |
| 15 | A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E,medicates angiogenesis via signaling through VEGFR-2 (KDR)but not VEGFR-1 (Flt-1) receptor tyrosine kinases显示文摘 | Meyer M Clauss M Lepple W A | 1999 | EMBO1999，18，2： | 1 |
| 16 | Phenotypic plasticity of size-fecundity relationships in Arabidopsis thaliana显示文摘 | Clauss M J Aarssen W | | 0，，： | 1 |
| 17 | Coordinate expression of vascular endothelial growth factor receptor-1 (flt-1) and its ligand suggests a paracrine regulation of murine vascular development显示文摘 | Breier G Clauss M Risau W | 1995 | Dev Dyn1995，204，： | 1 |
| 18 | The vascular endothelial growth factor receptor Fh-1 mediates biological activities : implications for a functional role of placenta growth factor in monocyte activation and chemotaxis 显示文摘 | Clauss M Weich H Breier G Knies U Rockl W Waltenberger J | 1996 | J Biol Chem1996，271，17： | 1 |
| 19 | Segmental differences in electrical properties and Na-transport of rabbit caecum, proximal and distal colon in vitro显示文摘 | Clauss W Schafe H Horch I | 1985 | Pflugers Arch1985，403，： | 1 |
| 20 | Drug induced arousal from the permanent vegetative state显示文摘 | Clauss R Nel W | 2006 | NeuroRehabilitation2006，21，1： | 1 |
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