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| 1 | Massive haemorrhage in liver transplantation:Consequences,prediction and management显示文摘From its inception the success of liver transplantation has been associated with massive blood loss. Massive transfusion is classically defined as > 10 units of red blood cells within 24 h, but describing transfusion rates over a shorter period of time may reduce the potential for survival bias. Both massive haemorrhage and transfusion are associated with increased risk of mortality and morbidity(need for dialysis/surgical site infection) following liver transplantation although causality is difficult to prove due to the observational design of most trials. The blood loss associated with liver transplantation is multifactorial. Portal hypertension secondary to cirrhosis results in extensive collateral circulation, which can bleed during hepatectomy particular if portal pressures are increased. Avoiding volume loading and maintenance of a low central venous pressure together with the use of vasopressors have been shown to reduce blood loss and transfusion during liver transplantation, but may increase the risk of renal impairment post-operatively. Coagulation defects may be present pre-transplant, but haemostasis is often re-balanced due to a deficit in both proand anti-coagulation factors. Further derangement of haemostasis may develop in the anhepatic and neohepatic phases due to absent hepatic metabolic function, hyperfibrinolysis and platelet sequestration in the donor liver. Point-of-care tests of coagulation such as the viscoelastic tests rotation thromboelastometry/thromboelastometry allow and more accurate and rapid assessment of these derangements in coagulation and guide the use of factor replacement and antifibrinolytics. Transfusion protocols guided by these tests have been shown to reduce transfusion rates compared with conventional coagulation tests, but have not shownimprovements in mortality or morbidity. Pre-operative factors associated with massive transfusion include previous surgery, re-do transplantation, the aetiology and severity of liver disease. Intra-operatively the use of piggy-back technique and avoiding veno-veno bypass has been shown to reduced blood loss. | Stuart Cleland Carlos Corredor Jia Jia Ye Coimbatore Srinivas Stuart A Mc Cluskey | 2016 | World Journal of Transplantation2016，6，2： | 11 |
| 2 | 上海市产后妇女避孕方法选择的定性研究显示文摘目的:了解上海市产后妇女避孕措施的选择及其影响因素,并了解妇幼保健和计划生育机构对产后避孕服务提供情况。方法:采用个人访谈和小组讨论的研究方法,对上海市分娩1年内的产妇以及参与产后家庭访视的妇幼保健和计划生育工作人员进行访谈。结果:妇女产后早期倾向选择对身体康复和哺乳没有影响的避孕套和安全期避孕,一段时期之后倾向选择避孕效率更高的方法。选择避孕方法的种类受妇产科医生的建议和亲戚朋友避孕经验的影响较大。产妇避孕知识整体水平不高,普遍不了解哺乳避孕法以及口服避孕药、皮下埋植剂等避孕方法。由于产后访视员避孕知识的不足使得产后访视几乎未开展有效的避孕指导。结论:采取多种措施,提高产妇避孕知识,扩大产后避孕方法的选择,改善产后访视的避孕指导。 | 车焱 John Cleland 韩耀玲 | 2007 | 中国计划生育学杂志2007，15，10： | 10 |
| 3 | 常规脂蛋白检测和载脂蛋白在心血管病预测中的比较显示文摘总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀类药物、有相关的脂质指标(n=346 686)的受试者。 | Welsh C Celis-Morales CA Brown R Mackay DF Lewsey J Mark PB Gray SR Ferguson LD Anderson JJ Lyall DM Cleland JG Jhund PS Gill J MR Pell JP Sattar N Welsh P 刘青(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，27，7： | 10 |
| 4 | 新型冠状病毒肺炎及其心血管效应:流行病学研究的系统综述显示文摘少数新型冠状病毒肺炎(新冠肺炎)患者病情严重,其特征是炎症、微血管损伤和凝血障碍,可能导致心肌损伤、静脉血栓栓塞症(venous thromboembolism, VTE)和动脉闭塞事件。有心血管病危险因素或既往有心血管病的个体可能面临更大的风险。目的:评估各种环境(包括社区、疗养院和医院)中,与新冠肺炎疑似或确诊病例相关的既往存在心血管合并症的患病率。研究者还评估了疑似或确诊新冠肺炎患者随后发生心血管并发症和临床事件的性质和发生率。 | Pellicori P Doolub G Wong CM Lee KS Mangion K Ahmad M Berry C Squire I Lambiase PD Lyon A McCon-nachie A Taylor RS Cleland JG 刘青(摘译) 练桂丽(审校) | 2021 | 中华高血压杂志2021，29，5： | 3 |
| 5 | 环境水样品中药物残留的潜在代谢物的鉴定显示文摘使用超高效液相色谱-串联四极杆飞行时间质谱(QTOF),对环境水样品中的药物和个人护理品(PPCPs)、滥用药物和农兽药等1000多种化合物进行高分辨质谱筛查,并对潜在代谢物进行结构鉴定.水样经过浓缩,使用ACQUITY UPLC HSS C18色谱柱分离后,进行UPLC-QTof分析.筛查出的潜在代谢物经UNIFI科学软件进行结构鉴定. | Gareth Cleland Mark Wrona Lauren Mullin Jennifer Burgess | 2015 | 环境化学2015，34，12： | 2 |
| 6 | Comparative Effects of Low and High Doses of the Angiotensin-Converting Enzyme Inhibitor, Lisinopril, on Morbidity and Mortality in Chronic Heart Failure显示文摘 | Milton Packer Philip A. Poole-Wilson Paul W. Armstrong John G.F. Cleland John D. Horowitz Barry M. Massie Lars Rydén Kristian Thygesen Barry F. Uretsky | 1999 | Circulation1999，，23： | 2 |
| 7 | Predictors of short term mortality in heart failure — Insights from the Euro Heart Failure survey显示文摘 | Periaswamy Velavan Nasrin K. Khan Kevin Goode Alan S. Rigby Poay H. Loh Michel Komajda Ferenc Follath Karl Swedberg Hugo Madeira John G.F. Cleland | 2008 | International Journal of Cardiology2008，，1： | 2 |
| 8 | Development and course of heart failure after a myocardial infarction in younger and older people显示文摘BackgroundAcute 心肌的梗塞(AMI ) 是心失败(HF ) 的一个普通原因,它能此后不久开发 AMI 并且可以晚坚持或解决或发展。在 MI 以后的 HF 是死亡的主要来源。在在不同年龄组的 MI 以后的 HF 的累积发生,流行和决定糟糕被描述。在 AMI 从医院记录在 1998 期间根据有 AMI 的 age.MethodsPatients 被识别以后,这研究描述 HF 的自然历史。HF 与环利尿剂被定义为症状的治疗和 HF 的症状并且如果没有症状的复发,环利尿剂治疗能被停止,被认为决定了。病人们 < 被分成那些;65 年, 65-75 年,和 >75 years.ResultsOf 896 个病人, 311, 297 和 288 被变老 <65, 65-75 和 > 75 年并且谁 24% , 57% 和 82% 由 2005 年 12 月分别地死了。这些死亡, 24 (8%) , 68 (23%) 并且(37%) 107 发生在索引承认期间,与尖锐 HF 联系的许多。A 推进 37 (12%) , 63 (21%) 并且(29%) 82 开发了坚持了直到分泌物, 15, 44 和 62 随后死于的 HF。在分泌物以后, 53 (24%) , 55 (40%) 并且 37 (47%) 病人们第一次开发了 HF,谁 26% , 62% 和 76% 随后死了。死亡被 HF 的发展在 35 先于(70%) , 93 (91%) 并且 107 (85%) 在年老的 <65 年, 65-75 年和 > 75 年,开发 HF 并且在 MI 以后死的 respectively.ConclusionsThe 风险与年龄日益增多地增加。不管年龄,在 MI 以后的大多数死亡被 HF 的发展先于。 | Azam Torabi John GF Cleland Alan S Rigby Nasser Sherwi | 2014 | Journal of Geriatric Cardiology2014，11，1： | 2 |
| 9 | Predictors of itch and pain in the 12 months following burn injury:results from the Burns Registry of Australia and New Zealand(BRANZ)Long-Term Outcomes Project显示文摘Background:Itch and pain are common complaints of patients with burn injuries.This study aimed to describe the prevalence and predictors of itch and moderate to severe pain in the first 12 months following a burn injury,and determine the association between itch,moderate to severe pain,workrelated outcomes,and health-related quality of life following a burn injury.Methods:Burn patients aged 18 years and older were recruited from five Australian specialist burn units.Patients completed the 36-item Short Form Health Survey Version 2(SF-36 V2),the Sickness Impact Profile(SIP)work scale,and a specially developed questionnaire relating to itch at 1,6,and 12 months post-injury.Moderate to severe pain was defined as a score less than 40 on the bodily pain domain of the SF-36 V2.Multivariate mixed-effects regression models were used to identify patient and burn injury predictors of itch and moderate to severe pain.Results:Three hundred and twenty-eight patients were included.The prevalence of itch decreased from 50%at 1 month to 27%at 12 months.Similarly,the prevalence of moderate to severe pain decreased from 23%at 1 month to 13%at 12 months.Compared to patients aged 18-34,the adjusted odds of experiencing any itch were 59%(95%CI:0.20,0.82)and 55%(95%CI:0.22,0.91)lower for patients aged between 35 and 49 and≥50 years,respectively.Compared to patients aged 18-34,the adjusted odds of experiencing moderate to severe pain were 3.12(95%CI:1.35,7.20)and 3.42(95%CI:1.47,7.93)times higher for patients aged 35-49 and≥50 years,respectively.Conclusions:Less than 15%of patients reported moderate or severe pain at 12 months,while approximately one-quarter of the patients reported itch at the same period.The presence of moderate to severe pain was associated with a greater negative impact on health-related quality of life and work outcomes compared to itch.Further research is needed to improve our ability to identify patients at higher risk of persistent itch and pain who would benefit from targeted review and intervention studies. | Lincoln M.Tracy Dale W.Edgar Rebecca Schrale Heather Cleland Belinda J.Gabbe on behalf of the BRANZ Adult Long-Term Outcomes Pilot Project participating sites and working party | 2020 | Burns & Trauma2020，8，1： | 2 |
| 10 | Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients显示文摘Background:Patients with burn injuries are considered to have an increased risk of venous thromboembolism(VTE).While untreated VTEs can be fatal,no studies have examined chemoprophylaxis effectiveness.This study aimed to quantify the variation in prevalence of VTE prophylaxis use in patients in Australian and New Zealand burns units and whether prophylaxis use is associated with in-hospital outcomes following burn injury.Methods:Admission data for adult burns patients(aged≥16 years)admitted between 1 July 2016 and 31 December 2018 were extracted from the Burns Registry of Australia and New Zealand.Mixed effects logistic regression modelling investigated whether VTE prophylaxis usewas associated with the primary outcome of in-hospital mortality.Results:There were 5066 admissions over the study period.Of these patients,81%(n=3799)with a valid response to the VTE prophylaxis data field received some form of VTE prophylaxis.Use of VTE prophylaxis ranged from 48.6%to 94.8%of patients between units.In-hospital death was recorded in<1%of patients(n=33).After adjusting for confounders,receiving VTE prophylaxis was associated with a decrease in the adjusted odds of in-hospital mortality(adjusted odds ratio=0.21;95%CI,0.07–0.63;p=0.006).Conclusions:Variation in the use of VTE prophylaxis was observed between the units,and prophylaxis use was associated with a decrease in the odds of mortality.These findings provide an opportunity to engage with units to further explore differences in prophylaxis use and develop future best practice guidelines. | Lincoln M.Tracy Peter A.Cameron Yvonne Singer Arul Earnest Fiona Wood Heather Cleland Belinda J.Gabbe | 2021 | Burns & Trauma2021，9，1： | 2 |
| 11 | Stable formulation of recombinant human growth hormone and interferon gamma for microencapsulation in biodegradable microspheres 显示文摘 | Cleland JL Jones AJS | 1996 | Pharr Res1996，13，10： | 2 |
| 12 | 异位妊娠与紧急避孕药的系统性回顾显示文摘目的通过评估现有的数据来估算服用紧急避孕药失败后的异位妊娠发生率。方法本研究包含了136项研究中的数据,这些研究的对象是服用过一次紧急避孕药(米非司酮或左炔诺孕酮)的女性,且妊娠次数与部位都已明确。结果由两名评价者背对背提取每篇文献中的数据。在米非司酮研究中,494妊娠中有3例(0.6%)异位妊娠;在左炔诺孕酮研究中,307例妊娠中异位妊娠有3例(1%)。结论服用紧急避孕药避孕失败后异位妊娠的发生率并不高于未服用人群,因紧急避孕药可有效降低妊娠危险,其应用也会减少性交而导致的异位妊娠。 | 井春梅 肖爱丽(译) 汤韧(校) Kelly Cleland | 2012 | 中国药物警戒2012，9，6： | 2 |
| 13 | Strengthening an in-service reinforcement concrete bridge with prestressed CFRP bars显示文摘Carbon fiber reinforced polymer (CFRP) bars were prestressed for the structural strengthening of 8 T-shaped rein-forced concrete (RC) beams of a 21-year-old bridge in China. The ultimate bearing capacity of the existing bridge after retrofit was discussed on the basis of concrete structures theory. The flexural strengths of RC beams strengthened with CFRP bars were controlled by the failure of concrete in compression and a prestressing method was applied in the retrofit. The field construction processes of strengthening with CFRP bars-including grouting cracks, cutting groove, grouting epoxy and embedding CFRP bars, surface treating, banding with the U-type CFRP sheets, releasing external prestressed steel tendons-were introduced in detail. In order to evaluate the effectiveness of this strengthening method, field tests using vehicles as live load were applied before and after the retrofit. The test results of deflection and concrete strain of the T-shaped beams with and without strengthening show that the capacity of the repaired bridge, including the bending strength and stiffness, is enhanced. The measurements of crack width also indicate that this strengthening method can enhance the durability of bridges. Therefore, the proposed strengthening technology is feasible and effective. | Hai-long WANG Wei-liang JIN David J. CLELAND Ai-hui ZHANG | 2009 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2009，10，5： | 2 |
| 14 | Bcl-x L Retrotranslocates Bax from the Mitochondria into the Cytosol显示文摘 | Frank Edlich Soojay Banerjee Motoshi Suzuki Megan M. Cleland Damien Arnoult Chunxin Wang Albert Neutzner Nico Tjandra Richard J. Youle | 2011 | Cell2011，，1： | 2 |
| 15 | The perindopril in elderly people with chronic heart failure (PEP-CHF) study 显示文摘 | Cleland JGF Tendera M Adamus J | 2006 | Eur Heart J2006，27，： | 1 |
| 16 | Real strength of highperformance concrete bridge deck slabs显示文摘 | TAYLOR S E RANKIN G I B CLELAND D J | 2003 | Proceedings of the Institution of Civil Engineers-Structures and Buildings2003，，： | 1 |
| 17 | β-blockers for heart failure: Why, which, when and where 显示文摘 | Cleland JGF | 2003 | Med Clin N Am2003，87，： | 1 |
| 18 | The effect of cardiac resynchronization on morbidity and mortality in heart failure显示文摘 | Cleland JG Daubert JC Erdmann E | 2005 | N Engl J Med2005，352，15： | 1 |
| 19 | Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005 ) : The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology 显示文摘 | Swedberg K Cleland J Dargie H | 2005 | Eur Heart J2005，26，11： | 1 |
| 20 | The effect of cardiac resynchronization on morbidity and mortality in heart failure 显示文摘 | Cleland JGF Daubert JC Erdmann E | 2005 | N Engl J Med2005，352，： | 1 |
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