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| 1 | LC-MS^n比较分析三种传统中草药中绿原酸及其衍生物组分(英文)显示文摘利用LC-MSn分析了杜仲叶、金银花叶以及鱼腥草叶甲醇提取物中绿原酸及其异构体和衍生物。发现3种样品中都含有3种单咖啡酰奎尼酸(绿原酸),分别是3-咖啡酰奎尼酸(3-caffeoylquinic acid,3-CQA)、4-CQA和5-CQA。杜仲叶和金银花叶中5-CQA为主要成分,但鱼腥草叶中以3-CQA和4-CQA为主要成分。在杜仲叶中首次发现咖啡酰奎尼酸糖苷;另外还发现金银花叶中有少量5-阿魏酰奎尼酸(5-feruloylquinic acid,5-FQA);鱼腥草叶含有少量的3-FQA和4-肉桂酰奎尼酸(4-p-coumaroylquinic acid,4-pCoQA)。本文首次报道鱼腥草叶中绿原酸异构体成分,为3-CQA和4-CQA的开发提供了来源(植物中绿原酸的结构一般以5-CQA为主)。 | 王征 CLIFFORD Michael N | 2008 | 药学学报2008，43，2： | 28 |
| 2 | Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research. | Clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd | 2019 | World Journal of Gastroenterology2019，25，28： | 16 |
| 3 | 全球语境下的新闻真实伦理显示文摘正如康复之于医学、批判思维之于教育一样,阐述真相是传媒业的职业准则,这是全球普遍的理解。在关于国际新闻业伦理规范的浩浩论述中,坦佩雷大学(Juusela,1981;Nordenstreng,1995)的(伦理)规范数据库与托马斯·库珀(Cooper,1989)的比较调查研究均指出,代表客观性和准确性的真实性是最重要的伦理规范。我们在全球范围内开展的关于社会责任的研究显示,在提供公正信息方面,新闻界担负着中心角色(Christians&Nordenstreng,2004)。阐述真相是新闻专业主义的基本核心,这是不争的事实,然而在全球语境下、尤其是技术复杂性日益'歪曲'真实的情况下,'真实'的概念以及新闻的本质都必须被重新定义。 | Clifford G.Christians 徐佳 | 2015 | 全球传媒学刊2015，2，1： | 11 |
| 4 | 机构知识库在美国的发展显示文摘1背景
2005年初,网络信息联盟(http://gffzz97eb856eb985430bhkqxfcvukq96c66px.ffgz.tsg.suse.edu.cn)对它在美国的学术成员机构进行了有关机构知识库发展现状的问卷调查。在同一时间,联盟为参加名为“为机构知识库构造一个战略性案例”的国际性会议而进行准备,开展了美国国家报告的信息编撰工作,因此,调查工作和信息编撰工作是一起进行的。“为机构知识库构造一个战略性案例”国际会议于2005年5月10-11日在阿姆斯特朗举办,网络信息联盟、英国联合信息系统委员会和荷兰SURF基金会联合主办此次国际会议。共有13个国家参会,他们分别提供了本国机构知识库的部署情况。 | Clifford A. Lynch Joan K. Lippincott 孙茜(编译) | 2005 | 图书情报工作动态2005，，11： | 8 |
| 5 | 基于信号质量评估和卡尔曼滤波的心率估计算法显示文摘目的:研究基于多导重症监护导联心电分析的逐搏心率估计算法。方法:通过开放源码的QRS搏动识别算法计算逐搏心率,通过分析信号的波形特征、统计特性和相互关系导出反映信号质量好坏的信号质量指数(signalqualityindex,SQI)。应用基于信号质量指数调节的卡尔曼滤波方法进行心率估计,通过残差值和信号质量指数的大小来动态调节卡尔曼滤波器的状态变量,获得逐搏心率的最佳估计。应用美国麻省理工学院多参数智能重症监护数据库II中437例病人的6000多小时高质量数据和人为添加真实心电干扰的数据进行算法评价。结果:与直接心率估计及采样保持等算法比较,本算法在严重干扰存在时,心率估计的均方根误差最小。结论:基于信号质量评估和卡尔曼滤波的心率估计算法在严重干扰存在时仍能提供精确的心率估计。 | 李桥 Roger G Mark Gari D Clifford 俞梦孙 | 2007 | 中国医学物理学杂志2007，24，6： | 8 |
| 6 | 亦真亦幻的核心竞争力显示文摘如今的管理者几乎把一切都视为潜在的核心竞争力。你的企业是否明显超出同行,其优势能否具体衡量出来?其出众之处能否长久维系,是否至关重要? | KevinP.Covne StephenJ.D.Hall Patricia Gorman Clifford | 2001 | 中国企业家2001，，9： | 8 |
| 7 | Neoadjuvant treatment strategies for intrahepatic cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinoma(ICC)is the second most common primary liver malignancy and is increasing in incidence.Long-term outcomes are optimized when patients undergo margin-negative resection followed by adjuvant chemotherapy.Unfortunately,a significant proportion of patients present with locally advanced,unresectable disease.Furthermore,recurrence rates are high even among patients who undergo surgical resection.The delivery of systemic and/or liver-directed therapies prior to surgery may increase the proportion of patients who are eligible for surgery and reduce recurrence rates by prioritizing early systemic therapy for this aggressive cancer.Nevertheless,the available evidence for neoadjuvant therapy in ICC is currently limited yet recent advances in liver directed therapies,chemotherapy regimens,and targeted therapies have generated increasing interest its role.In this article,we review the rationale for,current evidence for,and ongoing research efforts in the use of neoadjuvant therapy for ICC. | Clifford Akateh Aslam M Ejaz Timothy Michael Pawlik Jordan M Cloyd | 2020 | World Journal of Hepatology2020，12，10： | 8 |
| 8 | 13国大学机构知识库发展概况显示文摘1介绍
2005年5月10-11日。CNI、ISC以及SURF基金会举办了名为“创建机构知识库的战略”的研讨会。会议的目的是要广泛了解当前机构知识库在学术机构中的发展,并且对国家政策与战略的形成进行探讨。在会议的准备过程中,组织者就从十三个国家收集了机构知识库建设的有关信息,这3个国家包括澳大利亚、加拿大、美国、十个欧洲国家——比利时、法国、英国、丹麦、挪威、瑞典、芬兰、德国、意大利以及荷兰。 | Gerard van Westrienen Clifford A. Lynch 卢宏娟(译) | 2005 | 图书情报工作动态2005，，11： | 7 |
| 9 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 10 | 沙门氏菌的控制在饲料原料、饲料加工和动物生产中的重要性显示文摘 | Clifford A.Adams | 2002 | 中国家禽2002，24，15： | 6 |
| 11 | 算法导论(原书第3版)显示文摘定价:128元出版时间:2013年1月出版单位:机械工业出版社内容简介:在有关算法的书中,有一些叙述非常严谨,但不够全面;另一些涉及了大量的题材,但又缺乏严谨性。《算法导论(原书第3版)》将严谨性和全面性融为一体,深入讨论各类算法,并着力使这些算法的设计和分析能为各个层次的读者接受。 | Thomas H.Cormen Charles E.Leiserson Ronald L.Rivest Clifford Stein 殷建平 徐云 王刚 刘晓光 苏明 邹恒明 王宏志 | 2013 | 计算机教育2013，，10： | 5 |
| 12 | Malignancies of the Appendix: Beyond Case Series Reports显示文摘 | Marcia L. McGory M.D. Melinda A. Maggard M.D. M.S.H.S. Hakjung Kang M.D. Ph.D. Jessica B. O'Connell M.D. Clifford Y. Ko M.D. M.S. M.S.H.S | 2005 | Diseases of the Colon & Rectum2005，，12： | 5 |
| 13 | Sensitivity and inter-observer variability for capsule endoscopy image analysis in a cohort of novice readers显示文摘瞄准:为检测囊内视镜检查法调查结果决定新手阅读器(第 4 个年医学院的学生) 的性能。方法:小肠损害的十个囊内视镜检查法盒子予读者被以。标准答案调查结果被胃的肠学预先规定。十个标准答案“目标”在 10 个盒子之中被识别。读者们被给快速的读者软件的 30-min 概述并且指示标记畸形的任何潜在的区域。一个软件程序用 SAS 被开发分析缩小的调查结果。结果:为检测标准答案调查结果的全面敏感是 80% 。作为一个组,至少 5 从 10 个读者检测了每记录发现的每个标准答案。当读者的结果被联合时,所有标准答案目标被识别。偶然的 finding/false 积极的率每读者在 8.2-59.8 之间变化了。结论:有最小的内视镜的经验的医学院的学生的一块面板能在在囊内视镜检查法上检测损害完成高敏感。一组新手读者能预先屏蔽为进一步的评论缩小小肠损害的潜在的区域的记录。这些指图必须被考察决定临床的关联。进一步的研究是进行中的估计另外的队。 | Gary C Chen Pedram Enayati Tam Tran Mary Lee-Henderson Clifford Quan Gareth Dulai Ian Arnott James Sul Rome Jutabha | 2006 | World Journal of Gastroenterology2006，12，8： | 5 |
| 14 | Toward point-of-care management of chronic respiratory conditions:Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide显示文摘We present a portable non-invasive approach for measuring indicators of inflammation and oxidative stress in the respiratory tract by quantifying a biomarker in exhaled breath condensate(EBC).We discuss the fabrication and characterization of a miniaturized electrochemical sensor for detecting nitrite content in EBC using reduced graphene oxide.The nitrite content in EBC has been demonstrated to be a promising biomarker of inflammation in the respiratory tract,particularly in asthma.We utilized the unique properties of reduced graphene oxide(rGO);specifically,the material is resilient to corrosion while exhibiting rapid electron transfer with electrolytes,thus allowing for highly sensitive electrochemical detection with minimal fouling.Our rGO sensor was housed in an electrochemical cell fabricated from polydimethyl siloxane(PDMS),which was necessary to analyze small EBC sample volumes.The sensor is capable of detecting nitrite at a low over-potential of 0.7 V with respect to an Ag/AgCl reference electrode.We characterized the performance of the sensors using standard nitrite/buffer solutions,nitrite spiked into EBC,and clinical EBC samples.The sensor demonstrated a sensitivity of 0.21μAμM^(−1) cm^(−2) in the range of 20–100μM and of 0.1μAμM^(−1) cm^(−2) in the range of 100–1000μM nitrite concentration and exhibited a low detection limit of 830 nM in the EBC matrix.To benchmark our platform,we tested our sensors using seven pre-characterized clinical EBC samples with concentrations ranging between 0.14 and 6.5μM.This enzyme-free and label-free method of detecting biomarkers in EBC can pave the way for the development of portable breath analyzers for diagnosing and managing changes in respiratory inflammation and disease. | Azam Gholizadeh Damien Voiry Clifford Weisel Andrew Gow Robert Laumbach Howard Kipen Manish Chhowalla Mehdi Javanmard | 2017 | Microsystems & Nanoengineering2017，3，1： | 5 |
| 15 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 16 | 饲料对动物胃肠道完整性的影响显示文摘所有活动物均需定期采食饲料,饲料是一种复杂的物质,含有成千上万种不同分子及多种相关微生物。因此,饲料与其摄食者之间有明显互作,从而影响基于营养的动物健康(NbH)。饲料与动物的互作至少表现在3方面:维持胃肠完整性、支持免疫系统、调控氧化应激和疾病。 | Clifford A Adams(著) 武书庚(编译) 齐广海(审校) 李海涛(审校) | 2009 | 饲料与畜牧(新饲料)2009，，1： | 4 |
| 17 | Imaging shallow structure with active-source surface wave signal recorded by distributed acoustic sensing arrays显示文摘Distributed acoustic sensing(DAS) is one recently developed seismic acquisition technique that is based on fiber-optic sensing. DAS provides dense spatial spacing that is useful to image shallow structure with surface waves.To test the feasibility of DAS in shallow structure imaging,the PoroTomo team conducted a DAS experiment with the vibroseis truck T-Rex in Brady's Hot Springs, Nevada, USA.The Rayleigh waves excited by the vertical mode of the vibroseis truck were analyzed with the Multichannel Analysis of Surface Waves(MASW) method. Phase velocities between5 and 20 Hz were successfully extracted for one segment of cable and were employed to build a shear-wave velocity model for the top 50 meters. The dispersion curves obtained with DAS agree well with the ones extracted from co-located geophones data and from the passive source Noise Correlation Functions(NCF). Comparing to the co-located geophone array, the higher sensor density that DAS arrays provides help reducing aliasing in dispersion analysis, and separating different surface wave modes. This study demonstrates the feasibility and advantage of DAS in imaging shallow structure with surface waves. | Zhenghong Song Xiangfang Zeng Clifford H.Thurber Hebert F.Wang Dante Fratta | 2018 | Earthquake Science2018，31，4： | 4 |
| 18 | Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based on new evidence显示文摘 | Sidney Winawer Robert Fletcher Douglas Rex John Bond Randall Burt Joseph Ferrucci Theodore Ganiats Theodore Levin Steven Woolf David Johnson Lynne Kirk Scott Litin Clifford Simmang | 2003 | Gastroenterology2003，，2： | 4 |
| 19 | 动脉瘤性蛛网膜下腔出血患者出血后脑血管痉挛的介入治疗显示文摘本临床实践标准述及动脉瘤性蛛网膜下腔出血患者出血后脑血管痉挛(post—hemorrhagiccerebralvasospasm,PHCV)的介入治疗。这些结论基于神经介入外科学学会的标准委员会的评估,包括使用由美国心脏协会卒中委员会和牛津大学循证医学中心提出的循证医学指南进行的文献回顾。特别关注现有介入治疗方法的安全性和有效性,包括腔内球囊血管成形术(transluminalballoonangioplasty,TBA)和动脉内血管扩张药物输注治疗(intra-arterialvasodilatorinfusiontherapy,IAVT)。评估结果显示,这些侵袭性介入治疗可能有益,并可考虑用于PHCV,如伴有脑缺血症状和最佳的药物治疗无效的患者的治疗。概括起来,IAVT对累及近端和(或)远端颅内脑循环的PHCV可能有益,而TBA则可能对累及近端颅内脑循环的PHCV有益。评估结果显示,对于上述适应证,根据美国心脏协会指南可将TBA和IAVT归为IIb级推荐和B级证据,根据牛津大学循证医学中心指南则可归为4级推荐和C级证据。 | Todd Abruzzo Christopher Moran Kristine A Blacldaam Clifford J Eskey Raisa Lev Philip Meyers Sandra Narayanan Charles Joseph Prestigjacol~ 黄凯滨(译) 吴永明(译) | 2013 | 国际脑血管病杂志2013，21，1： | 4 |
| 20 | Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair显示文摘Maxillofacial bone defects are commonly seen in clinical practice.A clearer understanding of the regulatory network directing maxillofacial bone formation will promote the development of novel therapeutic approaches for bone regeneration.The fibroblast growth factor(FGF)signalling pathway is critical for the development of maxillofacial bone.Klotho,a type I transmembrane protein,is an important components of FGF receptor complexes.Recent studies have reported the presence of Klotho expression in bone.However,the role of Klotho in cranioskeletal development and repair remains unknown.Here,we use a genetic strategy to report that deletion of Klotho in Osx-positive mesenchymal progenitors leads to a significant reduction in osteogenesis under physiological and pathological conditions.Klotho-deficient mensenchymal progenitors also suppress osteoclastogenesis in vitro and in vivo.Under conditions of inflammation and trauma-induced bone loss,we find that Klotho exerts an inhibitory function on inflammation-induced TNFR signaling by attenuating Rankl expression.More importantly,we show for the first time that Klotho is present in human alveolar bone,with a distinct expression pattern under both normal and pathological conditions.In summary,our results identify the mechanism whereby Klotho expressed in Osx+-mensenchymal progenitors controls osteoblast differentiation and osteoclastogenesis during mandibular alveolar bone formation and repair.Klotho-mediated signaling is an important component of alveolar bone remodeling and regeneration.It may also be a target for future therapeutics. | Yi Fan Chen Cui Clifford JRosen Tadatoshi Sato Ruoshi Xu Peiran Li Xi Wei Ruiye Bi Quan Yuan Chenchen Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 3 |
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