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| 1 | Impaired coagulation,liver dysfunction and COVID-19:Discovering an intriguing relationship显示文摘Coronavirus disease 2019(COVID-19)is,at present,one of the most relevant global health problems.In the literature hepatic alterations have been described in COVID-19 patients,and they are mainly represented by worsening of underlying chronic liver disease leading to hepatic decompensation and liver failure with higher mortality.Several potential mechanisms used by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)to cause liver damage have been hypothesized.COVID-19 primary liver injury is less common than secondary liver injury.Most of the available data demonstrate how liver damage in SARSCo V-2 infection is likely due to systemic inflammation,and it is less likely mediated by a cytopathic effect directed on liver cells.Moreover,liver alterations could be caused by hypoxic injury and drugs(antibiotics and non-steroidal antiinflammatory drugs,remdesivir,tocilizumab,tofacitinib and dexamethasone).SARS-Co V-2 infection can induce multiple vascular district atherothrombosis by affecting simultaneously cerebral,coronary and peripheral vascular beds.Data in the literature highlight how the virus triggers an exaggerated immune response,which added to the cytopathic effect of the virus can induce endothelial damage and a prothrombotic dysregulation of hemostasis.This leads to a higher incidence of symptomatic and confirmed venous thrombosis and of pulmonary embolisms,especially in central,lobar or segmental pulmonary arteries,in COVID-19.There are currently fewer data for arterial thrombosis,while myocardial injury was identified in 7%-17%of patients hospitalized with SARS-Co V-2 infection and 22%-31%in the intensive care unit setting.Available data also revealed a higher occurrence of stroke and more serious forms of peripheral arterial disease in COVID-19 patients.Hemostasis dysregulation is observed during the COVID-19 course.Lower platelet count,mildly increased prothrombin time and increased Ddimer are typical laboratory features of patients with severe SARS-Co V-2 infection,described as“COVID-19 associated coagulopathy.”These alterations are correlated to poor outcomes.Moreover,patients with severe SARS-Co V-2 infection are characterized by high levels of von Willebrand factor with subsequent ADAMTS13 deficiency and impaired fibrinolysis.Platelet hyperreactivity,hypercoagulability and hypofibrinolysis during SARS-Co V-2 infection induce a pathological state named as“immuno-thromboinflammation.”Finally,liver dysfunction and coagulopathy are often observed at the same time in patients with COVID-19.The hypothesis that liver dysfunction could be mediated by microvascular thrombosis has been supported by postmortem findings and extensive vascular portal and sinusoidal thrombosis observation.Other evidence has shown a correlation between coagulation and liver damage in COVID-19,underlined by the transaminase association with coagulopathy,identified through laboratory markers such as prothrombin time,international normalized ratio,fibrinogen,D-dimer,fibrin/fibrinogen degradation products and platelet count.Other possible mechanisms like immunogenesis of COVID-19 damage or massive pericyte activation with consequent vessel wall fibrosis have been suggested. | Damiano D'Ardes Andrea Boccatonda Giulio Cocco Stefano Fabiani Ilaria Rossi Marco Bucci Maria Teresa Guagnano Cosima Schiavone Francesco Cipollone | 2022 | World Journal of Gastroenterology2022，28，11： | 5 |
| 2 | Narrow band imaging and high definition television in the assessment of laryngeal cancer:a propective study on 279 patients显示文摘 | Piazza C Cocco D Benedetto L | 2010 | Eur Arch Otorhinolaryngol2010，267，3： | 1 |
| 3 | Distribution ofVGF peptides in the human cortex and their selective changes in Parkinson's and Alzh- eimer's diseases显示文摘 | Cocco C D'Amato F Noli B | 2010 | J Anat2010，217，： | 1 |
| 4 | Coded aperture imaging in X-and gamma-ray astronomy显示文摘 | Caroli E Stephen J B Cocco G D | 1987 | Space Science Reviews1987，45，： | 1 |
| 5 | Stress - induced cardiomyopathy: a review 显示文摘 | Cocco G Chu D | 2007 | Eur 3 Intern Med2007，18，5： | 1 |
| 6 | High-precision measurements of the groove density of diffraction gratings显示文摘 | COCCO D SERGO R | 2000 | SPIE2000，4146，： | 1 |
| 7 | Performance of integrated gasification combined cycle power plants integrated with methanol synthesis processes 显示文摘 | Carapellucci R Cau G Cocco D | 2001 | Proceedings of the Institution of Mechanical Engineers2001，215，3： | 1 |
| 8 | Performance evaluation of chemically recuperated gas turbine (CRGT)power plants fuelled by di - methyl - ether( DME ) 显示文摘 | Cocco D Tola V Cau G | 2006 | Energy2006，31，10： | 1 |
| 9 | Nonatherosclerotic coronary artery disease and sudden death in the young显示文摘 | Corrado D Thiene G Cocco P | 1992 | Br Heart J1992，68，6： | 1 |
| 10 | Solving the dynamic rupture problem with different numerical approaches and constitutive laws 显示文摘 | Bizzarri A Cocco M Andrews D J Boshi E | 2001 | Geophys J Int2001，144，： | 1 |
| 11 | Transoral CO2 laser treatment for T(is)-T(3) glottic cancer: the University of Brescia experience on 595 patients显示文摘 | Peretti G Piazza C Cocco D | 2010 | Head Neck2010，32，8： | 1 |
| 12 | Role of narrow-band imaging and high-definition television in the surveillance of head and neck squamous cell cancer after chemo- and/or radiotherapy显示文摘 | Piazza C Cocco D De Benedetto L | 2010 | Euro Arch OtoRhinoLaryngol2010，267，9： | 1 |
| 13 | Transoral CO2 laser treatment for T(is) -T3 glottic cancer: the University of Brescia experience on 595 patients显示文摘 | Peretti G Piazza C Cocco D | 2010 | Head Neck2010，32，8： | 1 |
| 14 | Transoral CO2 laser treatment for Tis-T3 glottic cancer:the university of brescia experience on 595 patients显示文摘 | Peretti G Piazza C Cocco D | 2010 | Head Neck2010，32，： | 1 |
| 15 | Transoral C02 laser treatmentfor Tis-T3 glottic cancer: the University of Brescia experience on595 patients显示文摘 | Peretti G Piazza C Cocco D | 2010 | Head Neck2010，32，8： | 1 |
| 16 | Stress-induced cardiomyopathy 显示文摘 | Cocco G Chu D | 2007 | European Journal of Imernal Medicine2007，18，： | 1 |
| 17 | Transoral CO2laser treatment for Tis-T3 glottic cancer:The University of Brescia experience on 595patients显示文摘 | Peretti G Piazza C Cocco D | 2010 | Head Neck2010，32，8： | 1 |
| 18 | Patch test in the diagnosis of food allergy显示文摘 | Cocco R Sole D | 2009 | Allergol fmmunopathol (Madr)2009，37，4： | 1 |
| 19 | Performance evaluation of chemically recuperated gas turbine (CRGT) power plants fuelled by di- methyl - ether (DME) 显示文摘 | COCCO D TOLA V | 2006 | Energy2006，31，： | 1 |
| 20 | Interleukin-27 in- hibits pediatric B-acute lymphoblastic leukemia cell spreading in a preelinical model显示文摘 | CANALE S COCCO C FRASSON C et d | 2011 | Leukemia2011，25，12： | 1 |
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