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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Complete decoding of TAL effectors for DNA recognition显示文摘 | Ju n jiao Yang Yuan Zhang Pengfei Yuan Yuexin Zhou Changzu Cai Qingpeng Ren Dingqiao Wen Coco Chu Hai Qi Wensheng Wei | 2014 | Cell Research2014，24，5： | 3 |
| 3 | Preoperative chemoradiation with cisplatin and 5-fiuorouracil for extraperitoneal T3 rectal cancer:Acute toxicity,tumor response,sphincter preservation显示文摘 | Vanlentini V Coco C Cellini N | 1999 | Int J Radiat Oncol Biol Phys1999，45，12： | 1 |
| 4 | Tteatment of acute promyelocytic leukemia with gemtuznmab ozogamicin显示文摘 | Lo Coco F Ammatuna E Noguera N | 2006 | Clin AdvHermatol Oncol2006，4，1： | 1 |
| 5 | Preoperative chemoradiation with cisplatin and 5 - fluorouracil for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response, sphincter preservation 显示文摘 | Valentini V Coco C Cellini N | 1999 | lnt J Radiat Oncol Biol Phys1999，45，5： | 1 |
| 6 | Fundus autofluorescence in patients with age-related macnlar degeneration and high risk of visual loss显示文摘 | Lois N Owens SL Coco R | 2002 | Am J Ophthalmol2002，133，3： | 1 |
| 7 | preoperative chemoradiation for extraperitoneal T3 rectal cancer:acute toxicity, tumor response, and sphincter preservation 显示文摘 | Valentini V Coco C Cellini N | 1998 | Int J Radiat Oncol Biol Phy1998，40，5： | 1 |
| 8 | Preoperative chemoradiation with cisplatin and 5-fluorouracil for extraperitoneal T3 rectal cancer:acute toxicity,tumor response,sphincter preservation显示文摘 | Valentini V Coco C Cellini N | 1999 | Int J Radiat Oncol Biol Phys1999，45，5： | 1 |
| 9 | Preoperative chemoradiation with cisplatin and 5-fluorouracil for extraperitoneal T3 rectal cancer:acute toxicity,tumor response,sphincter preservation显示文摘 | Valentini V Coco C Cellini N | 1999 | Int J Radiat Oncol Biol Phys1999，45，5： | 1 |
| 10 | Preoperative chemora- diotherapy for extraperitoneal T3 rectal cancer:acute toxici- ty, tumor response, and sphincter preservation in three con- secutive studies 显示文摘 | Valentini V Coco C Cellini N | 2001 | Int J Radiat Oncol Biol Phys2001，51，2： | 1 |
| 11 | Definition of relapse risk and role of nonanthracycline drugs for consolidation in patients with acute promyelocytic leukemia:a joint study of the PETHEMA and GIMEMA cooperative groups显示文摘 | Sanz MA Lo Coco F Martín G | | 0，，04： | 1 |
| 12 | Factors affecting continuation rates of DMPA显示文摘 | Hubacher D Coco N Gonzalez B | 1999 | Contraception1999，60，6： | 1 |
| 13 | Ten yeas of preoperative chemoradiation for extraperitoeal T3 rectal cancer:acute toxicity,tumor response,and sphincter preservation in three consecutive studies显示文摘 | Valentini V Coco C Cellini N | 2001 | Int J Radiat Oncol Biol Phys2001，51，2： | 1 |
| 14 | Preoperative chemoradiation with cisplatin and 5-fluorouracil for extraperitoneal T3 rectal cancer: acute toxicity, tumor response, sphincter preservation显示文摘 | Valentini V Coco C Cellini N | 1999 | Int J Radiat Oneol Biol Phy1999，45，： | 1 |
| 15 | Preoperative chemoradiation for extraperitoneal T3 rectal cancer: acute toxicity, tumor response, and sphincter preservation显示文摘 | Valentini V Coco C Cellini N | 1998 | Int J Radiat Oncol Biol Phy1998，40，： | 1 |
| 16 | Cocaine and kidney injury: a ka- leidoscope of pathology显示文摘 | Goel N Pullman JM Coco M | 2014 | Clin Kidney J2014，7，： | 1 |
| 17 | Preoperative chemoradiation for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response and sphincter preservation显示文摘 | Valetini B Coco C Cellini N | 1998 | Int J Radiat Oncol Biol Phys1998，40，5： | 1 |
| 18 | Preoperative chemoradiation for extraperitoneal T3 rectal cancer acyte toxicity tumor resonse and sphincter 显示文摘 | Valentini V Coco C Celini N | 2012 | Int J Radiat Oncol Biol Phy2012，40，13： | 1 |
| 19 | Choice of chemotherapy in induction,consolidation and maintenance in acute promyelocytic leukaemia显示文摘 | Sanz M A Martín G Lo Coco F | 2003 | Best Pract Res Clin Haematol2003，16，3： | 1 |
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