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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Thalidomide therapy for patients with refractory Crohn's disease:an open-label trial(see camments)显示文摘 | Ehrenpreis ED Kane SV Cohen LB | 1999 | Gastroenterology1999，117，6： | 1 |
| 3 | Thalidomide therapy for patients with refractory Crohn'S disease:an open-lable trial显示文摘 | Ehrenpreis ED Kane SV Cohen LB | 1999 | Gastroenterology1999，117，6： | 1 |
| 4 | Endoscopic sedation in the United States:results from a nationwide survey 显示文摘 | Cohen LB Wecsler JS Gaetano JN | 2006 | Am J Gastroenterol2006，101，5： | 1 |
| 5 | AGA Institute review of endoscopic sedation 显示文摘 | Cohen LB Delegge MH Aisenberg J | 2007 | Gastroenterology2007，133，2： | 1 |
| 6 | Endoseopie sedation in the United States:results from a nationwide survey显示文摘 | Cohen LB Weesler JS Gaetano JN | 2006 | Am J Gas- troenterol2006，101，5： | 1 |
| 7 | Propofol for endoscopic sedation: A protocol for safe and effective administration by the gastroenterologist 显示文摘 | COHEN LB DUBOVSKY AN AISENBERG J | 2003 | Gastrointest Endosc2003，58，： | 1 |
| 8 | Moderate level sedation during endoscopy: a prospective study using low-dose propofol, meperidine/fentanil, and midazolam显示文摘 | COHEN LB HIGHTOWER CD WOOD DA | 2004 | Gastrointest Endose2004，59，： | 1 |
| 9 | Endoscopic sedation in developing and developed countries 显示文摘 | Benson AA Cohen LB Waye JD | 2008 | Gut Liver2008，2，2： | 1 |
| 10 | Male reproductive health after childhood, adolescent, and young adult cancers: a report from the Children's Oncology Group显示文摘 | Kenney LB Cohen LE Shnorhavorian M | 2012 | J Clin Oncol2012，30，27： | 1 |
| 11 | Propofol for endoscopic sedation: A protocol for safe and effective administration by the gastroen-terologist显示文摘 | COHEN LB DUBOVSKY AN | 2003 | Gastrointest Endosc2003，58，5： | 1 |
| 12 | Endoscopic sedation of patients with chronic liver disease显示文摘 | Bamji N Cohen LB | 2010 | Clin Liver Dis2010，14，2： | 1 |
| 13 | Relation between repolarization and refractoriness in the human ventricle: cycle length dependence and effect of procainamide显示文摘 | Lee RJ Liem LB Cohen TJ | 1992 | J Am Coll Cardiol1992，19，3： | 1 |
| 14 | AGA Institute re view of endoscopie sedation显示文摘 | Cohen LB Delegge MH Aisenberg J | 2007 | Gastroenterology2007，133，2： | 1 |
| 15 | Male reproductive health after childhood,adolescent,and young adult cancers:a report from the Children's Oncology Group显示文摘 | Kenney LB Cohen LE Shnorhavorian M | 2012 | J Clin Oncol2012，30，27： | 1 |
| 16 | Propofol use under the di- rection of trained gastoneterologists : an analysis of the medicolegal im- plications 显示文摘 | Aisenberg J Cohen LB Piorkowski JD Jr | 2007 | Am J Gastroenterol2007，102，4： | 1 |
| 17 | A large change in axon fluorescence that provides a promising method for measuring membrane potential显示文摘 | Davila HV Salzberg BM Cohen LB | 1973 | Nat New Biol1973，241，： | 1 |
| 18 | Thalidomide therapy for patients with refractory Crohn' s disease: an open-label trial 显示文摘 | Ehrenpreis ED Kane SV Cohen LB | 1999 | Gastroenterology1999，117，6： | 1 |
| 19 | Risk of bacterial or herpes simplex virus meningitis/encephalitis in children with complex febrile seizures显示文摘 | SELTZ LB COHEN E WEINSTEIN M | 2009 | Pediatr Emerg Care2009，25，8： | 1 |
| 20 | Thalidomide therapy for patients with refractory Crohn' s disease: an open-label trial显示文摘 | Ehrenpreis ED Kane SV Cohen LB | 1999 | Gastroenterology1999，117，6： | 1 |
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