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| 1 | Chronic overexpression of PNPLA3^sup I148M^ in mouse liver causes hepatic steatosis显示文摘 | Li John Zhong Huang Yongcheng Karaman Ruchan Ivanova Pavlina T Brown H Alex Roddy Thomas Castro-Perez Jose Cohen Jonathan C Hobbs Helen H | 2012 | EN2012，，11： | 3 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 4 | Expression transforming growth factor-βeta isoforms in human glomerular disease显示文摘 | YAMAMOTO T NOBLE N A COHEN A H | 1996 | Kidney Int1996，49，2： | 2 |
| 5 | Hyperspectral versus multispectral data for estimating leaf area index in four different biomes显示文摘 | Kyu-Sung Lee Warren B Cohen Robert E Kennedy Thomas K Maiersperger Stith T Gower | 2004 | Remote Sensing of Environment2004，，3： | 2 |
| 6 | 肝素的使用和监护显示文摘1绪论
到目前为止肝素仍然是应用最为广泛的抗凝药物。低分子肝素由于其安全、给药方便、有效和副作用小等特点正逐渐取代普通肝素而成为主要的抗凝药物。最近的进展包括使用合成的戊糖凝血因子Xa抑制剂fondaparinux,尽管其在预防和治疗血栓性疾病中的作用机制尚为完全明了,但与其他常规药物相比它具有了多项优势。 | Baglin T Barrowcliffe T W Cohen A 杨海燕(编译) 王兆钺(审校) | 2006 | 国际输血及血液学杂志2006，29，6： | 2 |
| 7 | Polar - A potent polyoxin B compound for controlling powdery mildews in apple and nectarine trees, and grapevines 显示文摘 | Reuveni M Cohen H Zahavi T | 2000 | Crop Protect2000，19，6： | 2 |
| 8 | Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits 显示文摘 | Miki T Cohen M Downey J | 1998 | Mol Cell Biochem1998，186，1： | 2 |
| 9 | Vascular endothelial growth factor (VEGF) and its receptors显示文摘 | Neufeld G Cohen T Gengrinovitch S | 1999 | FASEB J1999，13，1： | 1 |
| 10 | Degree Raising for Splines显示文摘 | Cohen E Lyche T Schumaker L L | 1986 | Journal of Approximation Theory1986，，46： | 1 |
| 11 | Sensitivity of Phytophthora infestans to Mandipropamid and the Effect of Enforeed Selection Pressure in the Field显示文摘 | COHEN Y RUBIN E HADAD T | 2007 | Plant Pathology2007，56，5： | 1 |
| 12 | Detecting High-Grade Cervical Disease on ASC-H Cytology Role of BD ProEx C and Digene Hybrid Capture Ⅱ HPV DNA Testing显示文摘 | Momin T Siddiqui Cynthia Cohen | 2008 | Am J Clin Pathol2008，130，： | 1 |
| 13 | Partnership nursing home care for dementia:the Glasgow experience one-year follow up 显示文摘 | Lyons D Cohen M Henderson T et a l | 1997 | Int-J-Geriatr Psychiatry1997，12，8： | 1 |
| 14 | Postcesarean fever and uterine rupture in a subsequent trial of labor显示文摘 | Shipp T Zelop C Cohen AP | 2001 | Am J Obstet Gynecol2001，184，2： | 1 |
| 15 | Determinants of Release Rate of Tetanus Vaccine from Polyester Microspheres显示文摘 | ALONSO M J COHEN S PARK T G | 1993 | Pharm Res1993，10，： | 1 |
| 16 | Stress,Social support and the buffering hypothesis显示文摘 | Cohen S Wills T A | 1985 | Psychological Bulletin1985，98，： | 1 |
| 17 | Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits显示文摘 | MIKI T COHEN MV DOWNEY JM | 1998 | Mol Cell Biochem (Netherlands)1998，186，12： | 1 |
| 18 | Vascular endothelial growth factor (VEGF) and its receptors 显示文摘 | Neufeld G Cohen T Gengrinovitch S | 1999 | FASEB J1999，13，1： | 1 |
| 19 | Copper-quinoline decarboxylation显示文摘 | Cohen T Schambach R A | 1970 | J Am Chem Soc1970，92，10： | 1 |
| 20 | Does needle insertion site affact discography results retrospective analysis 显示文摘 | Cohen SP Lark in T Fant GV | 2002 | Spine2002，27，20： | 1 |
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