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| 1 | 导致儿童期肥胖的生命早期危险因素:队列研究显示文摘目的确定早年(3岁以内)导致英国儿童肥胖的危险因素。设计前瞻性队列研究。方法Avon英国父母及儿童纵向调查研究。参与者参与队列研究的8234名年龄为7岁的儿童以及亚组的909名重点儿童,后者需额外提供与早期发育有关并涉及可能导致肥胖的各种资料。诊断标准7岁儿童体重指数≥95百分位确定为肥胖,参考1990年英国人口调查的诊断标准。结果经过最终验证,在假设的25项危险因素中有8项与肥胖有关:父母肥胖(父母双方校正后的相对危险度10.44,95%可信区间5.11~21.32);最早期(43个月内)的体重指数或体重反弹升高(校正后的相对危险度15.00,95%可信区间5.32~42.30);3岁时每周看电视的时间超过8小时(校正后的相对危险度1.55,95%可信区间1.13~2.12);追赶性生长(校正后的相对危险度2.60,95%可信区间1.09~6.16);8个月(校正后的相对危险度3.13,95%可信区间1.43~6.85)和18个月(校正后的相对危险度2.65,95%可信区间1.25~5.59)时体重的标准差值;1岁时体重增加值(校正后的相对危险度1.06,95%可信区间1.02~1.10,体重每增加100g);出生体重,每100g(校正后的相对危险度1.05,95%可信区间1.03~1.07);3岁时睡眠不足(<10.5小时,校正后的相对危险度1.45,95%可信区间1.10~1.89)。结论儿童期肥胖可能与8项危险因素有关。 | John J Reilly Julie Amstrong Ahmad R Dorosty Pauline M Emmett A Ness I Rogers Colin Steer Andrea Sherriff Children Study Team 冯凯 | 2005 | 英国医学杂志中文版2005，8，5： | 8 |
| 2 | miR-206 controls LXR alpha expression and promotes LXR-mediated cholesterol efflux in macrophages显示文摘 | Vinod M Chennamsetty I Colin S | 2014 | Biochim Biophys Acta2014，1841，6： | 1 |
| 3 | Pharmacological character- isation of oxytocin binding sites in the ovine pineal gland 显示文摘 | Hamid R R David K M Colin D I | 1997 | Regulatory Peptides1997，70，： | 1 |
| 4 | Functional lymphocyte subset assessment of the Th1/Th2 profile in patients with autoimmune thyroiditis by flowcytometric analysis of peripheral lymphocytes显示文摘 | COLIN I M ISAAC J DUPRET P | 2004 | J Biol Regul Homeost Agents2004，18，1： | 1 |
| 5 | Resistin up-regulates fractalkine expression in human endothelial cells lack of addictive effect with TNF-alpha显示文摘 | Manduteanu I Dragomir E Colin M | | 0，，01： | 1 |
| 6 | mi R-206 controls LXRαexpression and promotes LXR-mediated cholesterol efflux in macrophages显示文摘 | Vinod M Chennamsetty I Colin S | 2014 | Biochim Biophys Acta2014，6，： | 1 |
| 7 | The gonadotropin genes: evolution of distinct mechanisms for hormonal control 显示文摘 | Albanese C Colin I M Crowley W F | 1996 | Recent Progress in Hormone Research1996，51，： | 1 |
| 8 | Functional lymphocyte subset assessment of the Thl/Th2 profile in patients with autoimmune thy- roiditis by flowcytometric analysis in patients with autoimmune thyroiditis by flowcytometric analysis of peripheral lymphocyt 显示文摘 | Colin I M Isaac J Dupret P | 2004 | Biol Regul Homeost Agents2004，18，1： | 1 |
| 9 | Passive respiratory mechanics:the occlusion techniques显示文摘 | Gappa M Colin AA Goetz I | 2001 | Eur Respir2001，17，1： | 1 |
| 10 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 11 | Counting the dead and what they died of : an assessment of the global status of cause of death data 显示文摘 | COLIN D M DORIS M F MIE I | 2005 | Bull WHO2005，83，： | 1 |
| 12 | miR-206 controls LXRct expression and promotes LXR-mediated cholesterol efflux in mac- rophages显示文摘 | Vinod M Chennamsetty I Colin S | 2014 | Biochim Biophys Acta2014，1841，6： | 1 |
| 13 | Novel one step synthesis of cohalt (II)phthalocyanine-hydrotalcite catalysts for mercaptan oxidation in lightoil sweetening显示文摘 | Chatti I Ghorhel A Colin J M | 2002 | Studies in Surface Science and Catalysis2002，，： | 1 |
| 14 | Functional lymphocyte subset assessment of the Th1/Th2 profile in patients with autoimmune thyroiditis by flowcytometric analysis of peripheral lymphocytes显示文摘 | COLIN I M ISAAC J DUPRET P | 2004 | J Biol Regul Homeost Agents2004，18，1： | 1 |
| 15 | Long termreduction of microalbuminuria after 3 years of ACEI byperindpril in hypertensive diabetic patients显示文摘 | Brichard SM Colin I | 1992 | Am J Med1992，92，4： | 1 |
| 16 | Expression of nitric oxide synthase in human thyroid foullicular ceils: evidence for increased expression in hyperthyroidism显示文摘 | COLIN I M KOPP P ZBAREN J | 1997 | Eur J Endocrinol1997，136，6： | 1 |
| 17 | ACE2,a new regulator of the rennin-angiotensin system显示文摘 | Louise M B Colin I J Christos T | 2004 | Trends Endocrinol Metab2004，15，： | 1 |
| 18 | Passive respiratory mechanics: the occlusion techniques显示文摘 | Gappa M Colin AA Goetz I | 2001 | Eur Respir J2001，17，1： | 1 |
| 19 | Why blockade of the renin–angiotensin system reduces the incidence of new-onset diabetes显示文摘 | Karin AM Jandeleit-Dahm Christos Tikellis Christopher M Reid Colin I Johnston Mark E Cooper | 2005 | Journal of Hypertension2005，，： | 1 |
| 20 | miR-206 controls LXR~ expression and promotes LXR-mediated cholesterol efflux in macrophages 显示文摘 | Vinod M Chennamsetty I Colin S | 2014 | Biochim Biophys Acta2014，1841，6： | 1 |
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