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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 3 | A practical method for calculating largest Lyapunov exponents in from small data set显示文摘 | Rosenstein M T Collins J J De Luca C J | 1993 | Physica D1993，65，12： | 2 |
| 4 | A practical method for calculating largest Lyapunov exponents from small data sets显示文摘 | Rosenstein M T Collins J J Deluca C J | 1993 | Physica D1993，65，1： | 2 |
| 5 | A practical method for calculating largest Lyapunov exponents from small data sets显示文摘 | ROSENSTEIN M T COLLINS J J DE LUCA C J | 1993 | Physica D1993，65，1： | 1 |
| 6 | Deletion of the FHIT gene in neoplastic and invasive cervical lesions is related to high-risk HPV infection but is independent of histopathological features显示文摘 | Butler D Collins C Mabruk M | 2000 | J Pathol2000，192，： | 1 |
| 7 | A method for determining optimum sample size in species diversity studies显示文摘 | De Caprariis P Lindemann R H Collins C M | 1976 | Mathematical Geology1976，8，5： | 1 |
| 8 | A practical method for calculating largest Lyapunov exponents from small data sets显示文摘 | M T Rosenstein J J Collins C J Deluca | 1993 | Physica D1993，65，12： | 1 |
| 9 | Simplified modi- fied compression field theory for calculating shear strength of reinforced concrete elements 显示文摘 | Bentz E C Vecehio F J Collins M P | 2006 | ACI Structural Journal2006，103，4： | 1 |
| 10 | Encouraging Walking: The Case of Journey- to- school Trips in Compact Urban Areas显示文摘 | Black C Collins A Snell M | 2001 | Urban Studies2001，38，7： | 1 |
| 11 | Inheritance of glandular trichomes in tobacco显示文摘 | Johnson J C Nielsen M T Collins G B | 1988 | Crop Science1988，28，： | 1 |
| 12 | A practical method for calculating largest lyapunov exponents from small data sets显示文摘 | Rosenstein M T Collins J J De Luca C J | 1993 | Physics D: Nonlinear Phenomena1993，65，1： | 1 |
| 13 | Which Ore field signs/symptoms predict protracted recovery from sport- related concussion among high school football players? 显示文摘 | LAU B C KONTOS A P COLLINS M W | 2011 | Am J Sports Med2011，39，11： | 1 |
| 14 | Jackson and Schuler (1985) Revisted:Meta-Analysis of the Relationships Between Role Ambiguity,Role Conflict,and Job performance显示文摘 | Travis C Tubre Judith M Collins | 2000 | Journal of Management2000，26，1： | 1 |
| 15 | Comparing gel permeation chromatography and ultrafiltration for the molecular weight characterization of aquatic organic matter显示文摘 | Collins M R Kuo C J | 1987 | J AWWA1987，79，1： | 1 |
| 16 | A Spanish Translation of the Walking Impairment Questionnaire Was Validated for Patients with Peripheral Arterial Disease显示文摘 | Collins T C Suarez-Almazor M Petersen N J | 2004 | J Clin Epidemiol2004，57，12： | 1 |
| 17 | Loss of FHIT espression as a poteneial marker of malignant progression in preinvasive aquarnous cervical cancer 显示文摘 | Butler D Collins C Mabruk M | 2002 | Gynecol Oncol2002，86，2： | 1 |
| 18 | Uncoupling protein 2:a novel gene linked to obesity and hyperinsulinemia显示文摘 | Fleury C Neverova M Collins S | 1997 | Nat Genet1997，15，3： | 1 |
| 19 | Oxidative damage to DNA: Do we have a reliable biomarker? 显示文摘 | Collins A R Dusinska M Gedik C M | 1996 | Environmental Health Perspective1996，104，： | 1 |
| 20 | Uncoupling prtein 2:a novel gene linked to obesity and hypermsulinemia显示文摘 | Fleury C Neverova M Collins | 1997 | Diabetes1997，40，9： | 1 |
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