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| 1 | Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease:Need for mucosal viral load measurement显示文摘AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus(HCMV)and Epstein-Barr virus(EBV)infection in inflammatory bowel disease(IBD).METHODS:A cohort of 40 IBD patients(17 refractory)and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest.Viral infection was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry,and correlations with clinical and endoscopic indexes of activity,and risk factors were investigated.RESULTS:All refractory patients carried detectable levels of HCMV and/or EBV mucosal load as comparedto 13/23(56.5%)non-refractory and 13/40(32.5%)controls.The median DNA value was significantly higher in refractory(HCMV 286 and EBV 5.440 copies/105cells)than in non-refractory(HCMV 0 and EBV 6copies/105 cells;P<0.05 and<0.001)IBD patients and controls(HCMV and EBV 0 copies/105 cells;P<0.001 for both).Refractory patients showed DNA peak values≥103 copies/105 cells in diseased mucosa in comparison to non-diseased mucosa(P<0.0121 for HCMV and<0.0004 for EBV),while non-refractory patients and controls invariably displayed levels below this threshold,thus allowing us to differentiate viral colitis from mucosal infection.Moreover,the mucosal load positively correlated with the values found in the peripheral blood,whilst no correlation with the number of positive cells at immunohistochemistry was found.Steroid use was identified as a significant risk factor for both HCMV(P=0.018)and EBV(P=0.002)colitis.Finally,a course of specific antiviral therapy with ganciclovir was successful in all refractory patients with HCMV colitis,whilst refractory patients with EBV colitis did not show any improvement despite steroid tapering and discontinuation of the other medications.CONCLUSION:Viral colitis appeared to contribute to mucosal lesions in refractory IBD,and its correct diagnosis and management require quantitative real-time polymerase chain reaction assay of mucosal specimens. | Rachele Ciccocioppo Francesca Racca Stefania Paolucci Giulia Campanini Lodovica Pozzi Elena Betti Roberta Riboni Alessandro Vanoli Fausto Baldanti Gino Roberto Corazza | 2015 | World Journal of Gastroenterology2015，21，6： | 12 |
| 2 | Role of the advanced glycation end products receptor in Crohn's disease inflammation显示文摘AIM:To investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products(RAGE)in delayed apoptosis and tumor necrosis factor(TNF)-αproduction in Crohn’s disease(CD).METHODS:Surgical and endoscopic specimens from both inflamed and non-inflamed areas of the ileum and/or colon were collected from 20 and 14 adult CD patients,respectively,and used for the assessment of RAGE expression by means of immunohistochemistry and western blotting analysis.Normal tissues from 21 control subjects were used for comparison.The same polyclonal anti-human RAGE antibody(R and D System)was used in all experimental conditions.RAGE staining was quantized by a score including both the amount of positive cells and intensity of immunoreactivity;cellular pattern was also described.The effects of RAGE blocking on apoptotic rate and TNF-αproduction were investigated on immune cells freshly isolated from CD mucosa and incubated both with and without the muramyl dipeptide used as antigenic stimulus.Statistical analysis was performed via the test for trend,with regression models to account for intra-patient correlations.A 2-sided P<0.05 was considered significant.RESULTS:In inflamed areas,RAGE expression in both the epithelial and lamina propria compartments was higher than control tissues(P=0.001 and 0.021,respectively),and a cluster of positive cells were usually found in proximity of ulcerative lesions.Similar results were obtained in the lamina propria compartment of non-inflamed areas(P=0.025).The pattern of staining was membranous and granular cytosolic at the epithelial level,while in the lamina propria it was diffuse cytosolic.When evaluating the amount of protein expression by immunoblotting,a significant increase of both surface area and band intensity(P<0.0001 for both)was observed in CD inflamed areas compared to control tissue,while in non-inflamed areas a significant increase was found only for band intensity(P<0.005).Moreover,a significantly lower expression in noninflamed areas in comparison with inflamed areas was found for both surface area and band intensity(P<0.0006 for both).Finally,RAGE blocking largely affects both the apoptotic rate of mucosal cells(towards an increase in both non-inflamed and inflamed areas of P<0.001 and<0.0001,respectively)and TNF-αsecretion(towards a decrease in both non-inflamed and inflamed areas of P<0.05 and<0.01,respectively),mainly in the presence of antigenic stimulation.CONCLUSION:RAGE is up-regulated in CD,especially in inflamed areas,and it appears to play a role in the mechanisms involved in chronic inflammation. | Rachele Ciccocioppo Alessandro Vanoli Catherine Klersy Venerina Imbesi Vincenzo Boccaccio Rachele Manca Elena Betti Giuseppina Cristina Cangemi Elena Strada Roberta Besio Antonio Rossi Colomba Falcone Sandro Ardizzone Paolo Fociani Piergiorgio Danelli Gino Roberto Corazza | 2013 | World Journal of Gastroenterology2013，19，45： | 2 |
| 3 | Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis显示文摘BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the world.Their consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these patients.These risks also appear to be linked to the duration and the dosage.On the other hand,several studies have emerged with regard to the protective or therapeutic effects of these drugs.More and more evidence underlines the immunomodulatory and anti-fibrotic role of PPIs.In addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host cells.AIM To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and mortality.METHODS A literature review was performed in November 2020.The MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this topic.The search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and keywords.The MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were excluded.We tried to summarize and pool all the data if available.RESULTS A total of 9 studies were found that described the use of PPIs,of which only 5 clearly reported the severity and mortality data in SARS-CoV-2 patients.Our pooled incidence analysis of severe events did not differ between patients with and without PPIs(odds ratio 1.65,95%confidence interval:0.62-4.35)(P=0.314),or for mortality(odds ratio 1.77,95%confidence interval:0.62-5.03)(P=0.286).CONCLUSION Detailed and larger case studies are needed to accurately understand the role of PPIs in this viral infection. | Maddalena Zippi Sirio Fiorino Roberta Budriesi Matteo Micucci Ivan Corazza Roberta Pica Dario de Biase Claudio Giuseppe Gallo Wandong Hong | 2021 | World Journal of Clinical Cases2021，9，12： | 2 |
| 4 | An optical packet switch based on WDM technologies显示文摘 | Callegati F Corazza G Raffaelli C | 2005 | Lightwave Techology2005，23，3： | 1 |
| 5 | Patients with headache and functionaldyspepsia present meal–inducedhypersensitivity of the stomach显示文摘 | E. Pucci M. Stefano E. Miceli G. R. Corazza G. Sandrini G. Nappi | 2005 | The Journal of Headache and Pain2005，，4： | 1 |
| 6 | A Statistical Model for Land Mobile Satellite Channels and its Application to Nongeo Stationary Orbit Systems 显示文摘 | Corazza G E Vatalaro F | 1994 | IEEE Trans on VT1994，43，38： | 1 |
| 7 | Markerlessmotion capture through visual hull,articulated ICP andsubject specific model generation显示文摘 | Corazza S Mündermann L Gambaretto E | 2010 | International Journal ofComputer Vision2010，87，12： | 1 |
| 8 | Low-dose Acitretin in Treat- ment of Plaque-type Psoriasis: Descriptive Study of Efficacy and Safety显示文摘 | Borghi A Corazza M Maria AM | 2015 | Aeta Derm Venereo12015，95，2： | 1 |
| 9 | Use of the breeding technique to estimate the shape of the analysis 'errors of the day' 显示文摘 | Corazza M Kalnay E Patil D J | 2003 | Journal of Geophysical Re- search2003，10，： | 1 |
| 10 | Particle swarm optimization with non-smooth penalty reformulation, for a complex portfolio selection problem显示文摘 | Corazza M Fasano G Gusso R | 2013 | Applied Mathematics and Computation2013，224，1： | 1 |
| 11 | Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy显示文摘 | MICHEL O DENTENER M CORAZZA F | 2001 | J Allergy Clin Immunol2001，107，： | 1 |
| 12 | Anemia in children with cancer is associated with decreased erythopoitic activity and nor with inadequate erythropoietin production显示文摘 | Corazza F Beguin Y Bergmann P | 1998 | Blood1998，92，5： | 1 |
| 13 | Interaction of Copper with Cysteine: stability of Cuprous Complexes and Catalytic Role of Cupric Ions in Anaerobic Thiol Oxidation显示文摘 | Rigo A Corazza A | 2004 | Journal of Inorganic Biochemistry2004，98，9： | 1 |
| 14 | Physical exercise modulates peripheral levels of brain- derived neurotrophic factor(BDNF) :A systematic review of experimental studies in the elderly显示文摘 | Coelho F Gobbi S Andreatto C Corazza D Pedroso R Santos- Galdur6z R | 2013 | Archives Of Gerontology & Geriatrics2013，56，1： | 1 |
| 15 | Photobiomodulation on the angiogenesis of skin wounds in rats using different light sources 显示文摘 | Adalberto Vieira Corazza Jacks Jorge and Cristina Kurachi | 2007 | Photomedicine and Laser Surgery2007，25，2： | 1 |
| 16 | On the MAX/TC Criterion for Code Acquisition and Its Application to DS-SSMA Systems显示文摘 | CORAZZA G E | 1996 | IEEE Trans Commu1996，44，9： | 1 |
| 17 | Sweet’s Syndrome:A Retrospective Clinical,Histopathological and Immunohistochemical Analysis of11Cases显示文摘 | Corazza M Lauriola MM Borghi A | 2008 | Acta Derm Venereol2008，88，6： | 1 |
| 18 | Mortality in patients with coeliac disease and their relatives: a cohort study显示文摘 | Giovanni Corrao Gino Roberto Corazza Vincenzo Bagnardi Giovanna Brusco Carolina Ciacci Mario Cottone Carla Sategna Guidetti Paolo Usai Pietro Cesari Maria Antonietta Pelli Silvano Loperfido Umberto Volta Antonino Calabró Maria Certo | 2001 | The Lancet . 2001 (9279)2001，，9279： | 1 |
| 19 | Is it worth investigating splenic function in patients with celiac disease?显示文摘Celiac disease, an immune-mediated enteropathy induced in genetically susceptible individuals by the ingestion of gluten, is the most frequent disorder associated with splenic hypofunction or atrophy. Defective splenic function affects more than one-third of adult patients with celiac disease, and it may predispose to a higher risk of infections by encapsulated bacteria and thromboembolic and autoimmune complications, particularly when celiac patients have concomitant pre-malignant and malignant complications (refractory celiac disease, ulcerative jejunoileitis and enteropathy-associated T-cell lymphoma). However, the clinical management of patients with celiac disease does not take into account the evaluation of splenic function, and in patients with high degree of hyposplenism or splenic atrophy the prophylactic immunization with specific vaccines against the polysaccharide antigens of encapsulated bacteria is not currently recommended. We critically re-evaluate clinical and diagnostic aspects of spleen dysfunction in celiac disease, and highlight new perspectives in the prophylactic management of infections in this condition. | Antonio Di Sabatino Laura Brunetti Gabriella Carnevale Maffè Paolo Giuffrida Gino Roberto Corazza | 2013 | World Journal of Gastroenterology2013，19，15： | 1 |
| 20 | Continuous production of soybean biodiesel in supercritical ethanol-water mixtures显示文摘 | VIETEZ I da SILVA C BORGES G R CORAZZA F C OLIVEIRA J V GROMPONE M A JACHMANIAN I | 2008 | Energy Fuels2008，22，4： | 1 |
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