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| 1 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 2 | 评估饮用水中化学物暴露与健康结局:认识和研究需求现状显示文摘[背景]安全的饮用水对于健康至关重要。虽然在全球范围内,微生物污染仍然是饮用水相关疾病发病率和死亡率的最主要原因,但在供水中的化学物也可能导致疾病,而其中一些的人体健康结局的证据有限或缺乏。[目的]旨在总结当前人们对这一问题的了解状况,找出认识差距,并为与饮用水中化学物相关的流行病学研究提供建议。[讨论]评估饮用水中化学物暴露与健康结局十分具有挑战性。暴露通常为低浓度,在水中测量是通常是不够的,化学物以混合物形式存在,暴露时间通常很长,可能涉及多个暴露途径,而能够反映相应暴露阶段的有效生物标志却很少。此外,相对风险的幅度具有变小趋势。[结论]研究应该包括:设计良好的流行病学研究,涵盖能够比较污染程度并具有足够样本量的地区;结合生物分析并整合复杂混合物影响的污染物产生综合评价;足够水中测量次数,以评估地理和时间变异性;有关导致暴露的个人生活习惯的详细信息(例如,摄入、淋浴、游泳和饮食);生物样本的采集,以测量相关的生物标志;先进的统计模型,以评估暴露和相对风险,并应考虑解决测量误差的方法。最后,纳入早期生物效应和遗传易感性的分子标志对于了解化学物作用机制是必不可少的。需要评估大量新出现的污染物的风险和人类暴露,但这些知识仍然缺乏。 | Cristina M.Villanueva Manolis Kogevinas Sylvaine Cordier Michael R.Templeton Roel Vermeulen John R.Nuckols Mark J.Nieuwenhuijsen Patrick Levallois 汪源 张伊人 何蓉 金泰廙 | 2014 | 环境与职业医学2014，31，8： | 2 |
| 3 | 中法天文卫星(SVOM)伽玛暴联合探测任务显示文摘中法天文卫星SVOM是中法两国合作的伽玛暴探测任务,由中国国家航天局(CNSA)和法国国家空间研究中心(CNES)批准立项,中国科学院负责总体研制.SVOM是继美国SWIFT任务之后最重要的伽玛暴多波段探测项目,是一颗功能强大的天文卫星,具有多波段观测、快速机动、灵活操作及地面后随观测能力.SVOM将开创一个非常广阔的探测领域.本文介绍了项目组织、任务目标、卫星和有效载荷、地面段以及运控概念. | 余舜京 GONZALEZ Fran?ois 魏建彦 张双南 CORDIER Bertrand | 2019 | 空间科学学报2019，39，6： | 2 |
| 4 | Pediatric vascular tumors of the liver:Review from the pathologist’s point of view显示文摘Differential diagnosis of pediatric vascular liver tumors can be challenging due to inconsistent nomenclature,histologic overlap and the rarity of some entities.Here we give an up-to-date overview of the most important entities.We discuss the clinic,histology and pathophysiology of hepatic congenital and infantile heman-gioma,hepatic epithelioid hemangioendothelioma and hepatic angio-sarcoma. | Fleur Cordier Anne Hoorens Jo Van Dorpe David Creytens | 2021 | World Journal of Hepatology2021，13，10： | 2 |
| 5 | Onboard GRB trigger algorithms of SVOM-GRM显示文摘The Gamma-Ray Monitor(GRM)is a high energy detector onboard the future Chinese-French satellite named the Space-based multi-band astronomical Variable Object Monitor which is dedicated to studies of gamma-ray bursts(GRBs).This paper presents an investigation of the algorithms that look for GRBs by searching for a significant increase in the photon count rate for the computer onboard GRM.The trigger threshold and trigger efficiency,which are based on a given sample of GRBs,are calculated with the algorithms.The trigger characteristics of onboard instruments GRM and ECLAIRs are also analyzed.In addition,the impact of solar flares on GRM is estimated,and a method to distinguish solar flares from GRBs is investigated. | Dong-Hua Zhao Bo-Bing Wu Li-Ming Song Yong-Wei Dong Stphane Schanne Bertrand Cordier Jiang-Tao Liu | 2013 | Research in Astronomy and Astrophysics2013，13，11： | 2 |
| 6 | Effects of two types of exercise training on psychological well-being,sleep,quality of life and physical fitness in patients with high-grade glioma(WHO III and IV):study protocol for a randomized controlled trial显示文摘Background:There is existing evidence on whether and to what degree regular exercise training improves the quality of life(QoL)among cancer survivors.However,in regards to patients with high-grade glioma(HGG;WHO grade III and IV),no conclusive study has been performed so far.The present trial aims to fill this gap by examining whether psychological well-being,sleep,QoL and physical fitness might be improved with two different types of exercise,as compared to an active control condition.Active control condition represent individuals participating at regular meetings to talk about their current life situation,though,the meetings were not intended as that of the psychotherapy group.Regular meetings are of the same frequency,duration,and intensity as the exercise interventions.Methods:A total of 45 patients with HGG after undergoing neurosurgery and adjuvant radiotherapy,chemotherapy,or chemoradiotherapy will be consecutively and randomly assigned to(a)an endurance training,(b)a resistance training or(c)to an active control condition.The intervention will last for 6 consecutive weeks,consisting of 2 weekly sessions(30-45 min per session).Measurements would take place at three time points,namely at the beginning of the study(baseline),3 weeks after the beginning of the study,and 6 weeks after the beginning of the study.The last measurement also represents the end of the study.Aerobic exercise performance will be assessed objectively with a 6-min walking test,and a handgrip test will be used to assess the upper body strength.Further,participants will complete a battery of questionnaires covering sociodemographic information,QoL,sleep quality and sleep patterns,coping with stress,state-and trait-anxiety,depression,and fatigue.In parallel,experts will use the Hamilton Depres-sion Rating Scale to determine and rate participants’symptoms of depression.Significance:The present study will be the first to investigate and compare the impact of two different exercise modalities,namely endurance and resistance training,on physical fitness and dimensions of well-being,and sleep among patients with HGG who underwent neurosurgery followed by adjuvant radiotherapy,chemotherapy,or chemoradiotherapy.Importantly,unlike the majority of previous studies,the control condition consists of an active set-up to detect possible factual beneficial effects of exercise training,irrespective of social interactions. | Dominik Cordier Markus Gerber Serge Brand | 2019 | Cancer Communications2019，39，1： | 2 |
| 7 | Idiopathic Chronic Eosinophilic Pneumonia显示文摘 | Eric Marchand Jean-Fran?ois Cordier | 2006 | Semin Respir Crit Care Med2006，，02： | 2 |
| 8 | Conflicts versu analytical redundancy relations:a comparative analysis of the model based diagnosis approach from the artificial intelligence and automatic control perspectives显示文摘 | Cordier M O Dagne P Levy F | 2004 | IEEE Transactions on Systems Man & Cybernetics Part B:Cybernetics2004，34，5： | 1 |
| 9 | Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice 显示文摘 | Barton-Davis ER Cordier L Shoturma DI | 1999 | J Clin Invest1999，104，4： | 1 |
| 10 | Cutting planes for integer programs with general integer variables显示文摘 | CERIA S CORDIER C MARCHAND H | 1998 | Mathematical Programming1998，81，2： | 1 |
| 11 | Correlation of the WHO schema for the classification of thymic epithelial neoplasms with prognosis显示文摘 | Chalabreysse L Roy P Cordier JF | 2002 | Am J Surg Pathol2002，26，： | 1 |
| 12 | Cryptogenic organizing pneumonia 显示文摘 | Cordier JF | 2006 | Eur Respir J2006，28，： | 1 |
| 13 | Primary pulmonary lymphomas : a clinical study of 70 cases ; in nonimmunocompromised patients显示文摘 | Cordier JF Cbzilleuz E Lanquc D | 1993 | Chest1993，103，1： | 1 |
| 14 | Cryptogenic organizing pneumonia显示文摘 | Cottin V Cordier JF | 2012 | Semin Respir Crit Care Med2012，33，： | 1 |
| 15 | Cryptogenic organising pneumonia显示文摘 | Cordier JF | 2006 | Eur Respir J2006，28，： | 1 |
| 16 | Cryptogenic organising pneumonia显示文摘 | Cordier JF | 2006 | Eur Respir J2006，28，： | 1 |
| 17 | Establishment and characterization of ovine blood monocyte-derived cell lines显示文摘 | Olivier M Berthon P Chastang J Cordier G Lantier F | 2001 | Veterinary Immunology and Immunopathology2001，82，34： | 1 |
| 18 | Self-healing and thermoreversible rubber from supramolecular assembly 显示文摘 | Cordier Philippe Tournilhac Francois Corinne Souli-Ziakovic | 2008 | Nature2008，451，： | 1 |
| 19 | Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy? Results of a 3-year prospective study in a French hospital 显示文摘 | Vauloup -Fellous C Picone O Cordier AG | 2009 | J Clin Virol2009，46，4： | 1 |
| 20 | Cryptogenic organizing pneumonia显示文摘 | Cordier JF | 2004 | Clin Chest Med2004，25，4： | 1 |
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