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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | IL-6 and IGF-1 are Independent Prognostic Factors of Liver Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients显示文摘 | David García-Galiano Miguel A. Sánchez-Garrido Isabel Espejo José Luis Montero Guadalupe Costán Trinidad Marchal Antonio Membrives José M. Gallardo-Valverde Juan R. Mu?oz-Casta?eda Eugenio Arévalo Manuel Mata Jordi Muntané | 2007 | Obesity Surgery2007，，： | 2 |
| 3 | Comparison of ethanol concentrations in right cardiac blood,left cardiac blood and peripheral blood in a series of 30 cases显示文摘 | Pelissier-Alicot AL Coste N Bartoli C | 2006 | Forensic Sci Int2006，156，1： | 1 |
| 4 | 查看详情显示文摘 | Naulin C Costes M Moudden Z Ghanem N Dorthe G | | 0，，： | 1 |
| 5 | Both soluble and membrane-anchored forms of felid herpesvirus 1 glycoprotein G function as a broad-spectrum chemokinebinding protein显示文摘 | COSTES B RUIZ-ARGUELLO M B BRYANT N A | 2005 | J Gen Virol2005，86，12： | 1 |
| 6 | 3D flow around a rectangular cylinder:a computational study显示文摘 | BRUNO L FRANSOS D COSTE N | | 0，，67： | 1 |
| 7 | Effects of prone position and positive end-expiratory pressure on lung perfusion and ventilation显示文摘 | Richard JC Bregeon F Costes N etal | 2008 | Crit Care Med2008，36，： | 1 |
| 8 | Mechanics of granular materials at low effective stresses 显示文摘 | Sture S Costes N C Batiste S N Lankton M R Alshibli K A Jeremic B Swanson R A Frank M | 1998 | Journal of Aerospace Engineering1998，11，2： | 1 |
| 9 | Comparison of Throm-bolysis Followed by Broad Use of Percutaneous Coronary In-tervention With Primary Percutaneous Coronary Interventionfor ST-Segment-Elevation Acute Myocardial Infarction DataFrom the French Registry on Acute ST-Elevation MyocardialInfarction(FAST-MI)显示文摘 | Danchin N Coste P Ferrières J | 2008 | Circulation2008，118，： | 1 |
| 10 | Effects of prone position and positive end-expiratory pressure on hmg perfusion and ventilation 显示文摘 | Richard JC Bregeon F Costes N | 2008 | Crit Care Med2008，36，8： | 1 |
| 11 | Comparison of thrombolysis followed by broad use of percutaneous coronary intervention with primary percutaneous coronary intervention for ST-segment-elevation acute myocardial infarction: data from the french registry on acute ST-elevation myocardial infarction (FAST-MI) 显示文摘 | Danchin N Coste P Ferrieres J | 2008 | Circulation2008，118，3： | 1 |
| 12 | In vivo and in absence of a thymus,the enforced expression of the Notch ligands Delta-1 or Delta-4 promotes T cell development with specific unique effects显示文摘 | De La Coste A Six E Fzailleau N | 2005 | Immunology2005，174，： | 1 |
| 13 | Role of chromosome abnormalities in ectopic pregnancy 显示文摘 | Coste J Fernandez H Joye N | 2000 | Fertility and Sterility2000，74，： | 1 |
| 14 | Mechanisms leading to reversible mechanical dysfunction in severe CAD:alternatives to myocardial stunning显示文摘 | Mazzadi AN André-Fou(e)t X Costes N | | 0，，06： | 1 |
| 15 | Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury显示文摘 | Richard J C Bregeon F Leray V Le Bars D Costes N Tourvieille C | 2007 | Intensive Care Med2007，33，： | 1 |
| 16 | Comparison of thrombolysis followed by broad use ofpercutaneous coronary intervention with primary per-cutaneous coronary intervention for ST-segment eleva-tion acute myocardial infarction显示文摘 | DANCHIN N COSTE P FERRIERES J | 2008 | Circulation2008，118，： | 1 |
| 17 | Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure 显示文摘 | Dali-Youcef N Mataki C Coste A | 2007 | Proc Natl Acad Sci USA2007，104，10： | 1 |
| 18 | A 18 F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging显示文摘 | Costes N Merlet I Ostrowsky K | 2005 | J Nucl Med2005，46，12： | 1 |
| 19 | Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso显示文摘 | Didelot R M N Nagot N Costes M V | 2006 | British Journal of Cancer2006，95，8： | 1 |
| 20 | Comparison of efficacy and safety of a standard versus a loading dose of clopidogrel for acute myocardial infarction in patients>/=75years of age(from the FAST-MI registry)显示文摘 | Puymirat E Aissaoui N Coste P | 2011 | Am J Cardiol2011，108，6： | 1 |
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