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| 1 | 己酮可可碱增强(E)-(2′)-脱氧-氟亚甲基胞苷的细胞毒性和对宫颈癌细胞的放射增敏作用显示文摘目的:观察己酮可可碱(pentoxifylline, PTX)对(E)-(2')-脱氧-氟亚甲基胞苷[(E)-2’-deoxy-2’-(fluoromethylene) cytidine,FMdC]的细胞毒性和放射增敏作用的影响。方法: 在人类宫颈癌细胞系C33-A和C4-I, FMdC和PTX的细胞毒性和放射增敏作用应用MTT和克隆形成分析。两种药物的细胞毒性相互作用应用Isoborogram分析。常规照射剂量2 Gy时的放射增敏比(sensitive enhancement ratio, SER)定义为2 Gy时对照组存活分数(survival fraction, SF)和药物处理组SF之比(SER2Gy)。结果:PTX增加FMdC 对C33-A和C4-I 细胞的细胞毒性,并呈剂量依赖关系。单药FMdC对C4-I和C33-A的50%抑制浓度(50%inhibition concentration, IC50)分别为139.5 nmol/L和46.7 nmol/L。在C4-I细胞,0.25 mmol/L、0.5 mmol/L和1.0 mmol/L PTX降低FMdC的IC50至58.0 nmol/L、40.6 nmol/L和20.9 nmol/L。在C33-A细胞,0.25 mmol/L、0.5 mmol/L和1.0 mmol/L PTX降低FMdC的IC50至32.1 nmol/L、23.3 nmol/L和9.1 nmol/L。Isoborogram分析表明, FMdC和PTX的细胞毒性效应为相乘作用。应用克隆形成分析,照射前用30 nmol/L FMdC处理指数生长期C33-A和C4-I细胞48 h或照射后立即单用0.25~1.0 mmol/L PTX, 均能观察到各自的放射增敏作用; | 李晔雄 Philippe A. COUCKE | 2001 | 癌症2001，20，7： | 6 |
| 2 | Experimental analysis of the dynamic, mechanical behavior of a chicken egg 显示文摘 | Coucke P Ketelaere B De Baerdemaeker J De | 2003 | Journal of sound and vibration2003，266，： | 1 |
| 3 | Eggshell crack detection based on acoustic resonance frequency analysis显示文摘 | De Ketelaere B Coucke P De Baerdemaeker J | 2000 | Journal of Agricultural Engineering Research2000，76，1： | 1 |
| 4 | Primary non-Hodgkin's lymphoma of the nasal cavity:prognostic significance ofparanasal extension and the role of radiotherapy and chemothempy显示文摘 | Liyx M Coucke PA Li JY | 1998 | Cancer1998，93，3： | 1 |
| 5 | A common founder for the 35delG GJB2 gene mutation in connexin 26 hearing impairment显示文摘 | Van Laer L Coucke P Mueller RF | 2001 | J Med Genet2001，38，： | 1 |
| 6 | Primary non-Hodgkin's lymphoma of the nasal cavity:Prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy显示文摘 | Li YX Coucke PA Li JY | 1998 | Cancer1998，83，3： | 1 |
| 7 | Primary non-Hodgkin's lymphoma of the nasal cavity: prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy显示文摘 | Li YX Coucke PA Li JY | 1998 | Cancer1998，83，3： | 1 |
| 8 | Correlation between ear- ly perforation of cover screws and marginal bone loss : a retro- spective study 显示文摘 | Van AN Collaert B Coucke W | 2005 | J Clin Periodontol2005，35，1： | 1 |
| 9 | Primary non-Hodgkin's lymphoma of the nasal cavity: prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy 显示文摘 | Li YX Coucke PA Li JY | 1998 | Cancer1998，83，3： | 1 |
| 10 | Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families显示文摘 | | 1999 | Hum Mol Genet1999，8，7： | 1 |
| 11 | primary non-hodgkiffs lymphoma of the masalcauity: prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy显示文摘 | Li Y X Coucke P A Li J Y | 1998 | Cancer1998，83，： | 1 |
| 12 | Accura- cy of computer-aided implant placement显示文摘 | Van Assche N Vercruyssen M Coucke W | 2012 | Clbl Oral Im- plantsRes2012，23，16： | 1 |
| 13 | Expandingthe spectrum of MERS type 2 lesions, a particular form ofencephalitis 显示文摘 | Notebaert Al Willems J Coucke L | 2013 | Pediatr Neurol2013，48，2： | 1 |
| 14 | Primary nonHodgkin's lymphoma of the nasal cavity : prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy显示文摘 | Li Y X Coucke P A Li J Y | 1998 | Cancer1998，83，： | 1 |
| 15 | Primarynon-- Hod- gkin's lymphoma of the nasal cavity显示文摘 | Li YX Coucke P A | 1998 | Cancer1998，83，： | 1 |
| 16 | Primary non-Hodgkin's lymphoma of the nasal cavity:, prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy显示文摘 | Li YX Coucke PA Li JY | 1998 | Cancer1998，83，3： | 1 |
| 17 | Decreased local control following radiation therapy alone in early-stage glottie carcinoma withanterior commissure extension 显示文摘 | Zouhair A Azria D Coucke P | 2004 | Strahlenther Onkol2004，180，2： | 1 |
| 18 | Primary non-Hodgkin's lymphoma of the nasal cavity:prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy显示文摘 | Li Y X Coucke P A Li J Y | 1998 | Cancer1998，83，3： | 1 |
| 19 | Long-term changes in mi- crobiology and clinicalperiodontal variables after completion of fixed orthodontic appliances显示文摘 | Ghijselings E Coucke W Verdnnck A | 2014 | OrthodCraniofac Res2014，17，1： | 1 |
| 20 | Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD显示文摘 | Marjolijn Renard Bert Callewaert Machteld Baetens Laurence Campens Kay MacDermot Jean-Pierre Fryns Maryse Bonduelle Harry C. Dietz Isabel Mendes Gaspar Diogo Cavaco Eva-Lena Stattin Constance Schrander-Stumpel Paul Coucke Bart Loeys Anne De Paepe Julie De | 2011 | International Journal of Cardiology2011，，： | 1 |
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