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| 1 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 2 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 3 | Antimicrobial resistance profiles of dairy and clinical isolates and type strains of Enterococci 显示文摘 | Figueiredo Marques J J Tenreiro R Crespo M T B | 2005 | Inter J Food Microbiol2005，103，2： | 1 |
| 4 | Effieacy of recombinant interleukin-2 (rlL-2) in patients with advanced HIV- 1 infection and blunted immune response to HAART显示文摘 | Crespo M Caragol I Falco V | 2008 | Enferm Infecc Microbiol Clin2008，26，1： | 1 |
| 5 | ZAP-70 expression as a sunogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia显示文摘 | Crespo M Bosch F Villamor N | 2003 | N Engl J Med2003，348，18： | 1 |
| 6 | Integrated transport and reaction in an ion exchange membrane bioreactor 显示文摘 | Velizarov S Reis M A M Crespo J G | 2002 | Desali- nation2002，149，13： | 1 |
| 7 | The role of cytokinins and ethylene inhibitors on lenticel hypertrophy generation and ethylene production in vitro cultures of Populus euphratica Oliver显示文摘 | Liedo M D Crespo M B Amo-Marco J B | 1995 | Israel Journal of Plant Sciences1995，43，4： | 1 |
| 8 | Ammoxidized Kraft lignin as a slow-release fertilizer tested on sorghum vulgare显示文摘 | Ramirez F Gonzalez V Crespo M | 1997 | Bioresource Technology1997，，61： | 1 |
| 9 | Structural Characterization of Silver (I) Complexes (L=PPh3, PPh=Me, SC4Hs) and=AgLn=(CF=SO3) (n = 2-4), (L = PPh3, PPh2 Me) 显示文摘 | BARDAJI M CRESPO O LAGUNA A | 2000 | InorgChimActa2000，304，： | 1 |
| 10 | Increased expression of Ob-Rb and its relationship with the overexpression of TGF-betal and the stage of fibrosis in patients with nonalcoholic steatohepatitis显示文摘 | Cayón A Crespo J Mayorga M | 2006 | 26 (9):1065-10712006，26，9： | 1 |
| 11 | The role of cytokinins and ethylene inhibitors on lenticel hypertrophy generation and ethylene production in vitro cultures of Populus euphratica Oliver显示文摘 | Lledo M D Crespo M B Amomasco J B | 1995 | Israel of Plant Science1995，43，： | 1 |
| 12 | The digesrive tract of the amberjack Seriola dumerili,Risso:a light and scanning electron microscope study显示文摘 | GRAU A CRESPO S SARASQUETE M C | 1992 | Journal of Fish Biolo gy1992，41，： | 1 |
| 13 | Removal of trace mono-valent inorganic pollutants in an ion exchange membrane bioreactor: analysis of transport rate in a denitrification process 显示文摘 | VELIZAROV S REIS M A CRESPO J G | 2003 | Journal of Membrane Science2003，217，12： | 1 |
| 14 | Pathology teach and tell: eosinophilic granuloma 显示文摘 | Khalil F K Wallis Crespo M C Gilbert Barness E | 2004 | Fetal Pediatr Pathol2004，23，4： | 1 |
| 15 | Removal of tracemono-valent inorganic pollutants in an ion exchange membrane bio- reactor: Analysis of transport rate in a denitrification process 显示文摘 | Velizarov S Reis M A M Crespo J G | 2003 | Journal of Membrane Science2003，217，12： | 1 |
| 16 | Extraction and re- extraction of phenylalanine by cationic reversed micelles in hollow fibre contactors显示文摘 | CARDOSO M M VIEGAS R M C CRESPO J P S G | 1999 | Journal of Membrane Scince1999，156，2： | 1 |
| 17 | Twins born af- ter transplantation of ovarian conical tissue and oocyte vitrifica- tion 显示文摘 | Sanchez-Serrano M Crespo J Mirabet V | 2010 | Fertil Steril2010，93，26： | 1 |
| 18 | Com-parison between conventional ph measurement and multichannelintraluminal esophageal impedance in children with respiratorydisorders显示文摘 | Tolin Hemani M Crespo Medina M Luengo Herrero V | 2012 | An Pediatr (BArc)2012，77，2： | 1 |
| 19 | Integrated transport and reaction in an ion exchange membrane bioreactor显示文摘 | Velizarov S Reis M A Crespo J G | 2002 | Desalination2002，149，： | 1 |
| 20 | Kinetic theory of microstructural evolution in nucleation and growth processes显示文摘 | Crespo D Pradell T Clavaguera-Mora M T | 1997 | Phys Rev: B1997，55，： | 1 |
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