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| 1 | Assessing the quality of reports of randomized clinical trials: Is blinding necessary?显示文摘 | Alejandro R. Jadad R.Andrew Moore Dawn Carroll Crispin Jenkinson D.John M. Reynolds David J. Gavaghan Henry J. McQuay | 1996 | Controlled Clinical Trials1996，，1： | 25 |
| 2 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 3 | Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer显示文摘AIM:To characterize tumor necrosis factor receptorassociated protein 1(TRAP1)expression in the progression of ulcerative colitis(UC)-associated colorectal cancer.METHODS:Chronic UC is an inflammatory bowel disease that predisposes to colorectal cancer.Immunohistochemical analysis was used to evaluate TRAP1expression on tissue microarrays containing colonic tissues from 42 UC progressors(patients with cancer or dysplasia)and 38 non-progressors(dysplasia/cancer free patients).Statistical analyses of the TRAP1immunohistochemistry staining were performed using Graph Pad Prism.Differences in the TRAP1 level between non-progressors and progressors were tested for statistical significance using the Mann-Whitney test.Receiver operating characteristic curve method was used to quantify marker performance in distinguishing diseased cases from controls.RESULTS:TRAP1 was up-regulated in the colon tissues from UC progressors,but not in the colon tissues from UC non-progressors.Moreover,up-regulation of TRAP1 preceded the neoplastic changes:it was present in both the dysplastic and non-dysplastic tissues of UC progressors.When TRAP1 staining in rectal tissue was used as a diagnostic marker,it could distinguish progressors from non-progressors with 59%sensitivity and 80%specificity.Our study further showed that the increase of TRAP1 expression positively correlated with the degree of inflammation in the colorectal cancer tissues,which could be related to the increased oxidation present in the colonic mucosa from UC progressors.We then investigated the cellular proteome changes underlying oxidative stress,and found that oxidative stress could induce up-regulation of TRAP1 along with several other negative modulators of apoptosis.CONCLUSION:These results suggest that oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1,which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer. | Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 4 | Current research on pharmacologic and regenerative therapies for osteoarthritis显示文摘Osteoarthritis(OA)is a degenerative joint disorder commonly encountered in clinical practice,and is the leading cause of disability in elderly people.Due to the poor self-healing capacity of articular cartilage and lack of specific diagnostic biomarkers,OA is a challenging disease with limited treatment options.Traditional pharmacologic therapies such as acetaminophen,non-steroidal anti-inflammatory drugs,and opioids are effective in relieving pain but are incapable of reversing cartilage damage and are frequently associated with adverse events.Current research focuses on the development of new OA drugs(such as sprifermin/recombinant human fibroblast growth factor-18,tanezumab/monoclonal antibody againstβ-nerve growth factor),which aims for more effectiveness and less incidence of adverse effects than the traditional ones.Furthermore,regenerative therapies(such as autologous chondrocyte implantation(ACI),new generation of matrix-induced ACI,cell-free scaffolds,induced pluripotent stem cells(iPS cells or iPSCs),and endogenous cell homing)are also emerging as promising alternatives as they have potential to enhance cartilage repair,and ultimately restore healthy tissue.However,despite currently available therapies and research advances,there remain unmet medical needs in the treatment of OA.This review highlights current research progress on pharmacologic and regenerative therapies for OA including key advances and potential limitations. | Wei Zhang Hongwei Ouyang Crispin R Dass Jiake Xu | 2015 | Bone Research2015，3，4： | 9 |
| 5 | Assessing the quality of reports of randomized clinical trials: Is blinding necessary?显示文摘 | Alejandro R. Jadad R.Andrew Moore Dawn Carroll Crispin Jenkinson D.John M. Reynolds David J. Gavaghan Henry J. McQuay | 1996 | Controlled Clinical Trials1996，，1： | 7 |
| 6 | Characterization and in vitro release studies of oral microbeads containing thiolated pectin–doxorubicin conjugates for colorectal cancer treatment显示文摘Novel oral microbeads were developed based on a biopolymer–drug conjugate of doxorubicin(DOX) conjugated with thiolated pectin via reducible disulfide bonds. The microbeads were fabricated by ionotropic gelation with cations such as Al3+, Ca2+ and Zn2+. The results showed that using zinc acetate can produce the strongest microbeads with spherical shape.However, the microbeads prepared from thiolated pectin–DOX conjugate were very soft and irregular in shape. To produce more spherical microbeads with suitable strength, the native pectin was then added to the formulations. The particle size of the microbeads ranged from 0.87 to 1.14 mm. The morphology of the microbeads was characterized by optical and scanning electron microscopy. DOX was still in crystalline form when used in preparing the microbeads, as confirmed by powder X-ray diffractometry. Drug release profiles showed that the microbeads containing thiolated pectin–DOX conjugate exhibited reduction-responsive character;in reducing environments, the thiolated pectin–DOX conjugate could uncouple resulting from a cleavage of the disulfide linkers and consequently release the DOX. The best-fit release kinetics of the microbeads containing thiolated pectin–DOX conjugate, in the medium without reducing agent, fit the Korsmeyer–Peppas model while those in the medium with reducing agent fit a zero-order release model. These results suggested that the microbeads containing thiolated pectin–DOX conjugate may be a promising platform for cancer-targeted delivery of DOX, exploiting the reducing environment typically found in tumors. | Kamonrak Cheewatanakornkool Sathit Niratisai Somkamol Manchun Crispin R.Dass Pornsak Sriamornsak | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，6： | 6 |
| 7 | The Molecular Pathogenesis of Osteosarcoma: A Review显示文摘 | Matthew L. Broadhead Jonathan C. M. Clark Damian E. Myers Crispin R. Dass Peter F. M. Choong H. Kovar | 2011 | Sarcoma2011，，： | 4 |
| 8 | 应用三维重建超声组织多普勒成像技术测量心肌梗死左室不同部位的射血分数:活体羊实验研究(英文)显示文摘目的用三维重建超声组织多普勒成像(3DTDI)方法,研究左室壁运动特点及左室不同部分的射血分数(EF)。方法用重建的3DTDI的方法,对8只心尖部心肌梗死的活体羊模型在四种不同的血流状态下进行左室壁运动的测定和左室不同部分的EF测量。结果在四种不同的血流状态下,左室梗死区域的室壁运动振幅明显低于正常部分(P<0.001),整个左室、左室正常部分的EF明显高于梗死部分(P<0.001),左室正常部分的EF明显高于整个左室(0.0001 | 王慧芳 LI Xiao-kui David J.Sahn Michael Jones Crispin H.Davies Rosemary A.Rusk Arthur D.Zetts | 2004 | 中国现代医学杂志2004，14，18： | 4 |
| 9 | 三维重建组织多普勒成像测量心肌梗死面积的实验研究显示文摘目的 通过活体动物实验探讨三维重建组织多普勒超声成像测量心肌梗死面积的方法和可行性。方法 用三维重建组织多普勒显像的方法 ,对 8只开胸的心尖部心肌梗死和室壁瘤的活体羊模型在 4种不同的血流状态下进行心肌梗死面积的测量。结果 重建三维超声组织多普勒成像测量的活体羊心内膜梗死的面积与尸检标本测量的面积密切相关 (r =0 .90 ,Y =0 .83X +1 .33 ,s x =0 .92cm2 ,P <0 .0 0 0 1 )。结论 重建三维组织多普勒成像提供了一系列动态空间组织多普勒数据确定室壁异常运动区 ,并能定量测量心肌梗死面积 ,在缺血性心脏疾病中 。 | 王慧芳 Xiaokui Li David J.Sahn Michael Jones Crispin H.Davies Rosemary A.Rusk Arthur D.Zetts | 2002 | 中华超声影像学杂志2002，11，11： | 3 |
| 10 | Levels and trends of poly-and perfluoroalkyl substances in the Arctic environment-An update显示文摘Poly-and perfluoroalkyl substances(PFASs)are important environmental contaminants globally and in the early 2000s they were shown to be ubiquitous contaminants in Arctic wildlife.Previous reviews by Butt et al.and Letcher et al.have covered studies on levels and trends of PFASs in the Arctic that were available to 2009.The purpose of this review is to focus on more recent work,generally published between 2009 and 2018,with emphasis on PFASs of emerging concern such as perfluoroalkyl carboxylates(PFCAs)and short-chain perfluoroalkyl sulfonates(PFSAs)and their precursors.Atmospheric measurements over the period 2006e2014 have shown that fluorotelomer alcohols(FTOHs)as well as perfluorobutanoic acid(PFBA)and perfluoroctanoic acid(PFOA)are the most prominent PFASs in the arctic atmosphere,all with increasing concentrations at Alert although PFOA concentrations declined at the Zeppelin Station(Svalbard).Results from ice cores show generally increasing deposition of PFCAs on the Devon Ice cap in the Canadian arctic while declining fluxes were found in a glacier on Svalbard.An extensive dataset exists for long-term trends of long-chain PFCAs that have been reported in Arctic biota with some datasets including archived samples from the 1970s and 1980s.Trends in PFCAs over time vary among the same species across the North American Arctic,East and West Greenland,and Svalbard.Most long term time series show a decline from higher concentrations in the early 2000s.However there have been recent(post 2010)increasing trends of PFCAs in ringed seals in the Canadian Arctic,East Greenland polar bears and in arctic foxes in Svalbard.Annual biological sampling is helping to determine these relatively short term changes.Rising levels of some PFCAs have been explained by continued emissions of long-chain PFCAs and/or their precursors and inflows to the Arctic Ocean,especially from the North Atlantic.While the effectiveness of biological sampling for temporal trends in long-chain PFCAs and PFSAs has been demonstrated,this does not apply to the C4eC8ePFCAs,perfluorobutane sulfonamide(FBSA),or perfluorobutane sulfonate(PFBS)which are generally present at low concentrations in biota.In addition to air sampling,sampling abiotic media such as glacial cores,and annual sampling of lake waters and seawater would appear to be the best approaches for investigating trends in the less bioaccumulative PFASs. | Derek Muir Rossana Bossi Pernilla Carlsson Marlene Evans Amila De Silva Crispin Halsall Cassandra Rauert Dorte Herzke Hayley Hung Robert Letcher Frank Riget Anna Roos | 2019 | Emerging Contaminants2019，5，1： | 3 |
| 11 | Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn’s disease显示文摘BACKGROUND Tumor necrosis factor-alpha inhibitors,including infliximab and adalimumab,are effective medical treatments for perianal fistulising Crohn’s disease(CD),but not all patients achieve fistula healing.AIM To determine the correlation between perianal fistula healing and closure with infliximab and adalimumab trough levels.METHODS In this multicentre retrospective study conducted across four tertiary inflammatory bowel disease centres in Australia,we identified CD patients with perianal fistulae on maintenance infliximab or adalimumab who had a trough level within twelve weeks of clinical assessment.Data collected included demographics,serum infliximab and adalimumab trough levels(mg/L)within 12 wk before or after their most recent clinical assessment and concomitant medical or surgical therapy.The primary outcome was fistula healing,defined as cessation in fistula drainage.The secondary outcome was fistula closure,defined as healing and closure of all external fistula openings.Differences between patients who did or did not achieve fistula healing were compared using the chi-square test,t test or Mann-Whitney U test.RESULTS One hundred and fourteen patients(66 infliximab,48 adalimumab)were included.Forty-eight(72.7%)patients on maintenance infliximab achieved fistula healing and 18(27.3%)achieved fistula closure.Thirty-seven(77%)patients on maintenance adalimumab achieved fistula healing and 17(35.4%)achieved fistula closure.Patients who achieved fistula healing had significantly higher infliximab and adalimumab trough levels than patients who did not[infliximab:6.4(3.8-9.5)vs 3.0(0.3-6.2)mg/L,P=0.003;adalimumab:9.2(6.5-12.0)vs 5.4(2.5-8.3)mg/L,P=0.004].For patients on infliximab,fistula healing was associated with lower rates of detectable anti-infliximab antibodies and younger age.For patients on adalimumab,fistula healing was associated with higher rates of combination therapy with an immunomodulator.Serum trough levels for patients with and without fistula closure were not significantly different for infliximab[6.9(4.3-10.2)vs 5.5(2.5-8.3)mg/L,P=0.105]or adalimumab[10.0(6.6-12.0)vs 7.8(4.2-10.0)mg/L,P=0.083].CONCLUSION Higher maintenance infliximab and adalimumab trough levels are associated with perianal fistula healing in CD. | Bonita Gu Kavya Venkatesh Astrid-Jane Williams Watson Ng Crispin Corte Ali Gholamrezaei Simon Ghaly Wei Xuan Sudarshan Paramsothy Susan Connor | 2022 | World Journal of Gastroenterology2022，28，23： | 2 |
| 12 | The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells显示文摘 | William J. Harris Xu Huang James T. Lynch Gary J. Spencer James R. Hitchin Yaoyong Li Filippo Ciceri Julian G. Blaser Brigit F. Greystoke Allan M. Jordan Crispin J. Miller Donald J. Ogilvie Tim C.P. Somervaille | 2012 | Cancer Cell2012，，4： | 2 |
| 13 | Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer显示文摘The relationship between vitamin D metabolic enzymes (CYP27A1, CYP27B1, and CYP24A1) and vitamin D receptor (VDR) in nonmelanoma skin cancer (NMSC) development and progression is not entirely clear. However, several clinical studies and in vitro reports indicate a connection between vitamin D metabolic key players and NMSCs by demonstrating inhibitory effects on tumor cells and positive effects in skin cancer prevention of higher circulatory 25-hydroxyvitamin D [1]. Vitamin D synthesis is mediated via mitochondrial cytochrome P450 family hydroxylase enzymatic reactions: anabolic and catabolic hydroxylases (CYP27A1, CYP27B1, and CYP24A1). | Natalie Nemazannikova Gregory L. Blatch Crispin R. Dass Rodney Sinclair Vasso Apostolopoulos | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 2 |
| 14 | Photodegradation of hydroxyfluorenes in ice and water: A comparison of kinetics, effects of water constituents, and phototransformation by-products显示文摘The photochemical behavior of organic pollutants in ice is poorly studied in comparison to aqueous photochemistry.Here we report a detailed comparison of ice and aqueous photodegradation of two representative OH-PAHs,2-hydroxyfluorene(2-OHFL)and 9-hydroxyfluorene(9-OHFL),which are newly recognized contaminants in the wider environment including colder regions.Interestingly,their photodegradation kinetics were clearly influenced by whether they reside in ice or water.Under the same simulated solar irradiation(λ>290 nm),OHFLs photodegraded faster in ice than in equivalent aqueous solutions and this was attributed to the specific concentration effect caused by freezing.Furthermore,the presence of dissolved constituents in ice also influenced photodegradation with 2-OHFL phototransforming the fastest in‘seawater’ice(k=(11.4±1.0)×10^(−2) min^(−1))followed by‘pure-water’ice((8.7±0.4)×10^(−2) min^(−1))and‘freshwater’ice((8.0±0.7)×10^(−2) min^(−1)).The presence of dissolved constituents(specifically Cl^(−),NO_(3)^(−),Fe(Ⅲ)and humic acid)influences the phototransformation kinetics,either enhancing or suppressing phototransformation,but this is based on the quantity of the constituent present in the matrixes,the specific OHFL isomer and the matrix type(e.g.,ice or aqueous solution).Careful derivation of key photointermediates was undertaken in both ice and water samples using tandem mass spectrometry.Ice phototransformation exhibited fewer by-products and‘simpler’pathways giving rise to a range of hydroxylated fluorenes and hydroxylated fluorenones in ice.These results are of importance when considering the fate of PAHs and OH-PAHs in cold regions and their persistence in sunlit ice. | Linke Ge Shengkai Cao Crispin Halsall Junfeng Niu Dongxiao Bai Guangkai He Peng Zhang Hongrui Ma | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 15 | Ex vivo coronary atherosclerotic plaque characterization with multi-detector-row CT显示文摘 | Christoph R. Becker Konstantin Nikolaou Michael Muders Gregor Babaryka Alexander Crispin U. Joseph Schoepf Udo Loehrs Maximilian F. Reiser | 2003 | European Radiology2003，，9： | 1 |
| 16 | Quantification of regulatory T cells in patients with systemic lupus erythematosus显示文摘 | CRISPIN J C MARTINEZ A ALCOCER-VARELA J | 2003 | J Autoimmune2003，21，： | 1 |
| 17 | AIO KRK0306,FIRE3 trial:CEA and CA19-9 influence outcome of patients with KRAS exon wild-type metastatic colorectal cancer(m CRC)receiving first-line therapy with FOLFIRI plus cetuximab or bevacizumab显示文摘 | Michl M Fischer von Weikersthal L Crispin A | 2014 | J Clin Oncol2014，32，15： | 1 |
| 18 | Human keratinocytes' response to injury upregulates CCL20 and other genes linking innateaud adaptive immunity显示文摘 | Kennedy Crispin M BiUick E Mitsui H | 2012 | J Invest Dermatol2012，132，1： | 1 |
| 19 | Pathogenesis of human systemic lupus erythematosus: recent advances 显示文摘 | Crispin JC Liossis SN Kis-Toth K | 2010 | Trends Mol Med2010，16，2： | 1 |
| 20 | Quantification of regulatory T cells in patients with systemic lupus erythematosus显示文摘 | Crispin JC Martinez A Alcocer-Varela J | 2003 | J Autoimmun2003，21，3： | 1 |
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