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| 1 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 2 | Posterior interosseous nerve localization within the proximal forearm-a patient normalized parameter显示文摘AIM To provide a 'patient-normalized' parameter in the proximal forearm. METHODS Sixty-three cadaveric upper extremities from thirty-five cadavers were studied. A muscle splitting approach was utilized to locate the posterior interosseous nerve(PIN) at the point where it emerges from beneath the supinator. The supinator was carefully incised to expose the midpoint length of the nerve as it passes into the forearm while preserving the associated fascial connections, thereby preserving the relationship of the nerve with the muscle. We measured the transepicondylar distance(TED), PIN distance in the forearm's neutral rotation position, pronation position, supination position, and the nerve width. Two individuals performed measurements using a digital caliper with inter-observer and intraobserver blinding. The results were analyzed with the Wilcoxon-Mann-Whitney test for paired samples. RESULTS In pronation, the PIN was within two confidence intervals of 1.0 TED in 95% of cases(range 0.7-1.3 TED); in neutral, within two confidence intervals of 0.84 TED in 95% of cases(range 0.5-1.1 TED); in supination,within two confidence intervals of 0.72 TED in 95% of cases(range 0.5-0.9 TED). The mean PIN distance from the lateral epicondyle was 100% of TED in a pronated forearm, 84% in neutral, and 72% in supination. Predictive accuracy was highest in supination; in all cases the majority of specimens(90.47%-95.23%) are within 2 cm of the forearm position-specific percentage of TED. When comparing right to left sides for TEDs with the signed Wilcoxon-Mann-Whitney test for paired samples as well as a significance test(with normal distribution), the P-value was 0.0357(significance-0.05) indicating a significant difference between the two sides.CONCLUSION This 'patient normalized' parameter localizes the PIN crossing a line drawn between the lateral epicondyle and the radial styloid. Accurate PIN localization will aid in diagnosis, injections, and surgical approaches. | Srinath Kamineni Crystal R Norgren Evan M Davidson Ellora P Kamineni Andrew S Deane | 2017 | World Journal of Orthopedics2017，8，4： | 2 |
| 3 | Accuracy of sonographically guided 14-gauge core-needle biopsy:results of 715consecutive breast biopsies with at least two-year follow-up of benign lesions显示文摘 | Crystal P Koretz M Shcharynsky S | 2005 | J Clin Ultrasound2005，33，2： | 1 |
| 4 | CEO Compensation as Tournament and Social Comparison: A Tale of Two Theories 显示文摘 | O'Reilly C A Main B G Crystal G S | 1988 | Administrative Science Quarterly1988，33，2： | 1 |
| 5 | Nanophase iron-enhanced chemical reactivity of ground lunar soil 显示文摘 | WILLIAM T W CRYSTAL J P ANTONY S J | 2010 | Earth and Planetary Science Letters2010，295，34： | 1 |
| 6 | Mechanismsjputmonary fibrosis显示文摘 | Bitterman PR Adlberg S Crystal RG | 1983 | J Clin Invest1983，72，3： | 1 |
| 7 | Benzo (a) pyrene- induced acute neurotoxicity in the F-344 rat: role of oxidative stress 显示文摘 | Crystal R S Salil K D Aramandla R | 2006 | J Appl Toxicol2006，26，： | 1 |
| 8 | Using sonography to screen women with mammographically dense breasts 显示文摘 | Crystal P Strano SD Shcharynski S | 2003 | AJR Am J Roentgenol2003，181，1： | 1 |
| 9 | Coping, conflietual social interactions, social support, and mood among HIV-infected persons 显示文摘 | FLEISHMAN J A SHERBOURNE C D CRYSTAL S | 2000 | Am J Comm Psychol2000，28，4： | 1 |
| 10 | Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study 显示文摘 | Huybrechts KF Gerhard T Crystal S | 2012 | BMJ2012，344，： | 1 |
| 11 | CEO compensation as tournament and social comparison: a tale of two theories 显示文摘 | O'Reilly C A Main B G Crystal G S | 1988 | Administrative Science Quarterly1988，33，2： | 1 |
| 12 | Hemodialysis and hemoperfusion in a patient with an isolated phenytoin o- verdose显示文摘 | Miller M A Crystal G S Patel M M | 2006 | Am J Emerg Med2006，24，6： | 1 |
| 13 | The diverse older HIV - positive population: a national profile of economic circumstances, social support, and quality of life显示文摘 | Crystal S Akincigil A Sambamoorthi U | 2003 | J Acquir Immune Defic Syndr2003，33，2： | 1 |
| 14 | Left atrial ap- pendage qcclusion study : results of a randomized controlledpilot study of left atrial appendage occlusion during coronary bypass surgery in patients at risk for stroke显示文摘 | HEALEY J S CRYSTAL E LAMY A | 2005 | Am Heart J2005，150，2： | 1 |
| 15 | Digital and film mammography显示文摘 | Crystal P Strano S | 2006 | N Engl J Med2006，354，7： | 1 |
| 16 | New targets in advanced NSCLC: EML4-ALK显示文摘 | Crystal A S Shaw A T | 2011 | Clin Adv Hematol Oncol2011，9，3： | 1 |
| 17 | Airway epithelial cells: current concepts and challen- ges 显示文摘 | CRYSTAL R G RANDELL S H ENGELHARDT J F | 2008 | Proe Am Thorac Soc2008，5，7： | 1 |
| 18 | Stress, Social Support, and Distress in a Statewide Population of Persons with AIDS in New Jersey显示文摘 | Crystal S Kersting R C | 1995 | Soc Work Health Care1995，28，1： | 1 |
| 19 | Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angio- tensin receptor blockers: A Meta-Analysis显示文摘 | Healey J S Baranchuk A Crystal E | 2005 | J Am Coll Cardiol2005，45，11： | 1 |
| 20 | Where's the risk in CEO's Rewards? 显示文摘 | Crystal C S | 1988 | Fortune1988，，12： | 1 |
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