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| 1 | Effects of environmental contaminants on fertility and reproductive health显示文摘Recent research indicates that the human infertility rate is increasing. Although various reasons have been hypothesized for the growing infertility rate, environmental contaminants are potentially important causal agents associated with this change.Chemical contaminants are widespread throughout our environment and human exposure is virtually unavoidable. The overall contribution of environmental exposure to infertility is unknown, but studies involving occupational exposure, together with results from animal experiments, suggest that environmental contaminants may adversely affect fertility. We reviewed the adverse effects of environmental exposure on fertility and related reproductive outcomes. Environmental contaminants covered in this review include heavy metals, organic solvents, pesticides and endocrine disrupting chemicals. It is hoped that this review will highlight the need for further research in this area. | Yanmin Ma Xin He Keyan Qi Tong Wang Yongchao Qi Lele Cui Fengbang Wang Maoyong Song | 2019 | Journal of Environmental Sciences2019，31，3： | 6 |
| 2 | Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China显示文摘The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change. | Yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming LI Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG | 2019 | Science China Earth Sciences2019，62，10： | 5 |
| 3 | Angel: a new large-scale machine learning system显示文摘Machine Learning(ML) techniques now are ubiquitous tools to extract structural information from data collections. With the increasing volume of data, large-scale ML applications require an efficient implementation to accelerate the performance. Existing systems parallelize algorithms through either data parallelism or model parallelism. But data parallelism cannot obtain good statistical efficiency due to the conflicting updates to parameters while the performance is damaged by global barriers in model parallel methods. In this paper, we propose a new system, named Angel, to facilitate the development of large-scale ML applications in production environment. By allowing concurrent updates to model across different groups and scheduling the updates in each group, Angel can achieve a good balance between hardware efficiency and statistical efficiency. Besides, Angel reduces the network latency by overlapping the parameter pulling and update computing and also utilizes the sparseness of data to avoid the pulling of unnecessary parameters. We also enhance the usability of Angel by providing a set of efficient tools to integrate with application pipelines and provisioning efficient fault tolerance mechanisms. We conduct extensive experiments to demonstrate the superiority of Angel. | Jie Jiang Lele Yu Jiawei Jiang Yuhong Liu Bin Cui | 2018 | National Science Review2018，5，2： | 3 |
| 4 | Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) inhibits platelet apoptosis in immune-induced bone marrow failure through mitochondrial pathway显示文摘OBjECTIVE: To investigate the effect of Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) on the platelet number in immune-induced bone marrow failure(BMF) and its mechanism of mitochondrial apoptotic pathway.METHODS: Immune-induced BMF model, established in mice, was randomly divided into four groups: normal control group without BMF, BMF control group, cyclosporine(CSA) group and flavone group(n = 10 in each group). Mice were given0.027 g/kg cyclosporine or 0.2 g/kg flavone lavage daily in either the cyclosporine or flavone group respectively. Platelet count, mitochondrial transmembrane potential(ΔΨm), cytochrome C(Cyt C), phosphatidylserine(PS), changes of calcium ion(Ca^(2+)),and protein expression of mitochondrial apoptotic pathway including B-cell lymphoma-2(bcl-2) Homologous Antagonist-Killer Protein(Bak), bcl-2-associated X protein(Bax), caspase-3, caspase-8, and caspase-9 were examined and compared.RESULTS: Compared with the normal control group, the BMF group had significantly lower levels of platelet count, ΔΨm, and expressions of caspase family proteins as well as higher levels of Cyt C, PS,Ca^(2+), and expressions of Bak and Bax(all P < 0.05).Compared with the BMF group, the CSA and flavone groups had significantly higher ΔΨm and expressions of caspase family proteins(all P < 0.05)whereas the levels of Cyt C, PS, Ca^(2+), and expressions of Bak and Bax were reduced(all P < 0.05).More importantly, the flavone group had higher levels of Cyt C, Ca^(2+)and expressions of Bak and Bax compared with the CSA group(all P < 0.05), while the levels of PS and caspase family proteins were reduced(all P < 0.05).CONCLUSION: Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) significantly increases the platelet number and prevents its apoptosis through mitochondrial pathway. | Jiang Yiling Zheng Qin Zhang Aiping Cui Lele Xia Lemin Luo Meihong | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 2 |
| 5 | Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe显示文摘Carboxylesterase 1(CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and iso form-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity,sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CESl activities in several biological systems including tissue preparations,living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research. | Lele Ding Zhenhao Tian Jie Hou Tongyi Dou Qiang Jin Dandan Wang Liwei Zou Yadi Zhu Yunqing Song Jingnan Cui Guangbo Ge | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 6 | Sieve M-estimator for a semi-functional linear model显示文摘We propose sieve M-estimator for a semi-functional linear model in which the scalar response is explained by a linear operator of functional predictor and smooth functions of some real-valued random variables.Spline estimators of the functional coefficient and the smooth functions are considered,and by selecting appropriate knot numbers the optimal convergence rate and the asymptotic normality can be obtained under some mild conditions.Some simulation results and a real data example are presented to illustrate the performance of our estimation method. | HUANG LeLe WANG HuiWen CUI HengJian WANG SiYang | 2015 | Science China Mathematics2015，58，11： | 2 |
| 7 | The Jidong Eye Cohort Study:objectives,design,and baseline characteristics显示文摘Background:To describe the objective,design and baseline characteristics of the Jidong Eye Cohort Study(JECS),a community-based cohort in China based on etiology,imaging and biomarkers.The JECS will clarify the pathogenesis of visual impairment and status of ocular indicators in the occurrence and progression of cardiocerebrovascular and neurological diseases.Methods:Between August 2019 and January 2020,the JECS recruited consecutive participants aged 18 years and older from the Jidong communities in China.The demographic and clinical characteristics were collected by trained site personnel via face-to-face interviews.The relevant biological samples were also collected.The participants underwent comprehensive ophthalmic examination,such as retinal photography and optical coherence tomography(OCT)angiography.The following outcomes were measured annually:ocular vascular abnormality,optic nerve degeneration,cardiovascular diseases(CVD)and neurological diseases.The study will be performed until 2024.Results:Among 3377 participants,the average age was 45.0±12.5 years and 1809(53.6%)were women.Hypertension occurred in 825 individuals(25.0%),diabetes in 258(7.7%),hyperglycemia in 474(14.2%),and a CVD history in 100(3.0%).The mean best-corrected visual acuity was 0.1 logMAR in the recruited subjects.The average OCT signal index was 8.2±1.2.Additionally,the mean vessel densities for the entire measured area were 46.4%and 50.8%for the superficial and deep vascular complex,respectively.Mean area and perimeter of foveal avascular zone was 0.3 mm2 and 2.3 mm.Conclusions:The JECS is a large community-based prospective cohort in North China.Rich data collected from this study will provide the opportunity to identify risk factors,imaging,and biomarkers of visual impairment(either ocular vascular anomalies or optic nerve degeneration)and to evaluate their associations with CVD and neurological diseases. | Kai Yang Lele Cui Guoyun Zhang Xianwei Wang Xiaoxuan Zhu Yunfan Xiao Binbin Su Daiyu Song Xinyao Zhang Yang Zheng Fan Lu Jia Qu Ming Li | 2020 | Eye and Vision2020，7，1： | 0 |
| 8 | Design of New Farm Machine for Chopping Field Straw,Pressing it into Soil and Cleaning up Plastic Film显示文摘In this paper,we design a farm machine integrating the functions of chopping field straw,pressing field straw into soil,breaking stubble,and cleaning up plastic film,in order to improve the efficiency of plastic film cleaning,enrich the function of straw chopping equipment,reduce the noise generated at work,and further realize the intelligent harmony. The remote control button is used to control the work of the entire system,and the bluetooth remote control module and matrix keyboard are used to control the vehicle. With STM32 microcontroller as the main control chip,the machine controls the motion of the electric motor by relay,and employs LCD screen to realize real-time display of system work. It is convenient and easy to operate,with good human-computer interaction. | Jiqiang CUI Lele HE | 2017 | Asian Agricultural Research2017，9，3： | 0 |
| 9 | Highly delocalized endohedral metal in Gd@C2v(9)-C82 metallofullerenes co-crystallized with α-Se显示文摘 | Cheng Li Xuejiao J. Gao Huanli Yao Huan Huang Rongli Cui Xihong Guo Lele Zhang Bing Liu Binggang Xu Weiqun Shi Jinquan Dong Lai Feng Xingfa Gao Baoyun Sun | 2018 | Nano Research2018，11，4： | 0 |
| 10 | Dietary ribose supplementation improves flesh quality through purine metabolism in gibel carp(Carassius auratus gibelio)显示文摘Since the aquaculture industry is currently observing a deterioration in the flesh quality of farmed fish,the use of nutrients as additives to improve the flesh quality of farmed fish species is a viable strategy.The aim of this study was to investigate the effect of dietary D-ribose(RI)on the nutritional value,texture and flavour of gibel carp(Carassius auratus gibelio).Four diets were formulated containing exogenous RI at 4 gradient levels:0(Control),0.15%(0.15RI),0.30%(0.30RI)and 0.45%(0.45RI).A total of 240 fish(150±0.31 g)were randomly distributed into 12 fibreglass tanks(150 L per tank).Triplicate tanks were randomly assigned to each diet.The feeding trial was carried out in an indoor recirculating aquaculture system for 60 d.After the feeding trial,the muscle and liver of gibel carp were analysed.The results showed that RI supplementation did not result in any negative impact on the growth performance and 0.30RI supplementation significantly increased the whole-body protein content compared to the control group.The contents of collagen and glycogen in muscle were enhanced by RI supplementation.The alterations in the flesh indicated that RI supplementation improved the texture of the flesh in terms of its water-holding capacity and hardness,therefore improving the taste.Dietary RI facilitated the deposition of amino acids and fatty acids in the muscle that contributed to the meaty taste and nutritional value.Furthermore,a combination of metabolomics and expression of key genes in liver and muscle revealed that 0.30RI activated the purine metabolism pathways by supplementing the substrate for nucleotide synthesis and thereby promoting the deposition of flavour substance in flesh.This study offers a new approach for providing healthy,nutritious and flavourful aquatic products. | Wanjie Cai Lele Fu Cui Liu Linyue He Haokun Liu Dong Han Xiaoming Zhu Yunxia Yang Junyan Jin Shouqi Xie | 2023 | Animal Nutrition2023，，2： | 0 |
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