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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin-treated dogs显示文摘 | Cain SM | 1992 | Am Rev Respir Dis1992，145，： | 1 |
| 3 | Experimental models of pathologic oxygen supply dependency显示文摘 | Cain SM Curtis SE | 2002 | Crit Care Med2002，19，5： | 1 |
| 4 | The family conference as a focus to improve communication about end-of-life in the intensive care unit:opportunities for improvement显示文摘 | Curtis JR Patrick DL Shannon SE | 2001 | Crit Care Med2001，29，2： | 1 |
| 5 | Experimental models of pathologic oxygen supply dependency显示文摘 | Cain SM Curtis SE | 1991 | Crit Care Med1991，19，5： | 1 |
| 6 | Systematic review of tumor necrosis factor inhibitor discontinuation studies in rheumatoid arthritis显示文摘 | Navarro-Milldn I Sattui SE Curtis JR | 2013 | Clin Ther2013，36，11： | 1 |
| 7 | Systemic and regional O2 delivery and uptake in bled dogs given hypertonic saline, whole blood, or dextran显示文摘 | Curtis SE Cain SM | 1992 | Am J Physiol1992，262，32： | 1 |
| 8 | Immunoglobulins in piglets from sows heat-stressed prepartum显示文摘 | Machado-Neto R Graves CN Curtis SE | 1987 | J Anim Sci 1987Aug1987，65，44： | 1 |
| 9 | Perflubron partial liquid ventilation (PIN) in children with ARDS:A safety and efficacy pilot study显示文摘 | Toro - Figueroa LO Melinoes JN Curtis SE | 1996 | Crit Care Med1996，24，： | 1 |
| 10 | Prognostic value of the dobutamine test in patients with sepsis syndrome and normal lactate values : a prospective, muhicenter study 显示文摘 | Vallet B Chopin C Curtis SE | 1993 | Crit Care Med1993，21，12： | 1 |
| 11 | Role of the vascular endothelium in 02 extraction during progressive ischemia in canine skeletal muscle 显示文摘 | Curtis SE | 1995 | Appl Physiol1995，79，4： | 1 |
| 12 | Sediment storage of phosphorus in a northern prairie wetland receiving mu- nicipal and agro-industrial wastewater 显示文摘 | WHITE JS BAYLEY SE CURTIS PJ | 1999 | Ecological Engineering1999，14，1： | 1 |
| 13 | Experimental models of pathologic oxygen supply dependency显示文摘 | Cain SM Curtis SE | 2002 | Crit Care Med2002，19，5： | 1 |
| 14 | Molecular evolution of chloroplast DNA sequences显示文摘 | CURTIS SE CLEGG MT | 1984 | Mol Biol Evol1984，1，： | 1 |
| 15 | Partial liquid ventilation in children with ARDS:a safety and efficacy pilot study显示文摘 | Toro-Figcroa LO Melioners JN Curtis SE | 1996 | Crit Care Med1996，24，： | 1 |
| 16 | Role of the vascular endothelium in O2 extraction during progressive ischemia in canine skeletal muscle 显示文摘 | Curtis SE | 1995 | J Appl Physiol1995，，： | 1 |
| 17 | Experimental models of pathologic oxygen supply dependency显示文摘 | Cain SM Curtis SE | | 0，，05： | 1 |
| 18 | Gut and muscle tissue PO2 in endotoxemic dogs during shock and resuscitation显示文摘 | Vallet B Lund N Curtis SE | 1994 | Appl Physiol1994，76，2： | 1 |
| 19 | Role of the vascular endothelium in O2 extraction during progressive ischemia in canine skeletal muscle显示文摘 | | 1995 | J Appl Physiol1995，79，4： | 1 |
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