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| 1 | Cardiac implications of thrombotic thrombocytopenic purpura显示文摘Thrombotic thrombocytopenic purpura(TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on plateletmediated micro-thrombi formation, leading to microvascular thrombosis.Autopsy studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, MI and sudden cardiac death. There is limited knowledge about optimal cardiac evaluation and management in patients with TTP. The absence of typical cardiac symptoms,combined with complicated multi-organ involvement in TTP, may contribute to the under-utilization of cardiac evaluation and treatment. Prompt diagnosis and timely initiation of effective therapy could be critically important in selected cases. Based on our experience and this review of the literature, we developed several recommendations for focused cardiac evaluation for patients with acute TTP:(1) patients with suspected or confirmed TTP should be screened for the potential presence of cardiac involvement with detailed history and physical,electrocardiogram and cardiac enzymes;(2) clinical deterioration of TTP patients warrants immediate cardiac reevaluation;(3) TTP patients with clinical evidence of cardiac involvement should be monitored for telemetry, cardiac biomarkers and evaluated with transthoracic echocardiography. These patients require urgent targeted TTP treatment as well as cardiac-specific treatment. Aspirin therapy is indicated for all TTP patients. Since epicardial coronary artery involvement is rare, cardiac catheterization is usually not required, given the high risk for hemorrhage and kidney injury;(4) we recommend evidence-based medical therapy for ischemic symptoms and heart failure. TTP patients with evidence of cardiac involvement would also benefit from routine cardiology follow up during remission. | Szymon L Wiernek Bo Jiang Gregory M Gustafson Xuming Dai | 2018 | World Journal of Cardiology2018，10，12： | 2 |
| 2 | 显示文摘 | Cheng Y L Dai J M Wu DJ | 2010 | J Magn Magn Mater2010，322，： | 1 |
| 3 | Gene expression profiling predicts clinical outcome of breast cancer 显示文摘 | van't Veer L J Dai H van de Vijver M J | 2002 | Nature2002，415，6871： | 1 |
| 4 | Trastuzumab combined with docetaxel-based regimens in previously treated metastatic gastric cancer patients with HER2 over-expression显示文摘 | Dai G H Shi Y Chen L Lv Y L Zhong M | 2012 | Hepatogastroenterology2012，59，： | 1 |
| 5 | CH4-CO2 reforming by plasma-challenges and opportunities显示文摘 | TAO X M BAI M G LI X LONG H L SHANG S Y YIN Y X DAI X Y | | 0，，02： | 1 |
| 6 | IrrE, a global regulator of extreme radiation resistance inDeinococcus radiodurans, enhances salt tolerance in Escherichia coli and Brassica napus显示文摘 | Pan J Wang J Zhou Z Yan Y Zhang W Lu W Ping S Dai Q Yuan M Feng B Hou X Zhang Y Ma R Liu T Feng L Wang L Chen M Lin M | 2009 | PloS One2009，4，2： | 1 |
| 7 | Expression pattern genomic struc- ture, and promoter analysis of the gene encoding stilbene synthase from Chinese wild Vitis pseudoreticulata显示文摘 | XU W R YU Y H ZHOU Q DING J H DAI L M XIE X Q XU Y ZHANG C H WANG Y J | 2011 | Journal of Experimen- tal Botany2011，62，8： | 1 |
| 8 | Reliability of classification system for intertrochanteric fractures of the proximal femur in experienced orthopaedic surgeons显示文摘 | Jin W J Dai L Y Cui Y M | 2005 | Injury2005，36，7： | 1 |
| 9 | Terahertz time- domain spectroscopy characterization of the far-infrared absorption and index of refraction of high-resistivity, float- zone silicon显示文摘 | Dai J M Zhang J Q Zhang W L | 2004 | Optical Society of America B2004，21，7： | 1 |
| 10 | Usability of a patient education and motivation tool using heuristic evaluation显示文摘 | Joshi A Arora M Dai L | 2009 | Med Int Res2009，11，4： | 1 |
| 11 | Anal Chim Acta显示文摘 | Jing T Xia H Guan Q Lu W H Dai Q Niu J W Lim J M Hao Q L Lee Y Zhou Y K Mei S R | 2011 | 692:732011，692，： | 1 |
| 12 | Dual-band bandpass filter using parallel short-ended feed scheme 显示文摘 | Dai G L Guo Y X Xia M Y | 2010 | IEEE Micro- wave Wireless Component Letters2010，20，6： | 1 |
| 13 | The left and right inverse eigen-value problems of generalized reflexive and anti-reflexive matrices显示文摘 | Liang M L Dai L F | 2010 | J Comput Appl Math2010，234，3： | 1 |
| 14 | Role and significance ofextracellular polymeric substances on the property of aerobic granule显示文摘 | Zhu L Lv M L Dai X | 2012 | BioresoureeTechnology2012，107，： | 1 |
| 15 | Hydrothermal synthesis and crystal structure of two new-Keggin derivatives decorated by transition metal complexes 显示文摘 | DAI L M MA Y WANG E B | 2006 | Trans Metal Chem2006，31，： | 1 |
| 16 | Reliability of classi- fication systems for intertrochanteric fractures of the proximal femur in experienced orthopaedic surgeons 显示文摘 | Jin W J Dai L Y Cui Y M | 2005 | Injury2005，36，7： | 1 |
| 17 | Paeonol attenuates high-fat-diet-induced atherosclerosis in rabbits by anti-inflammatory activiry显示文摘 | Li H Dai M Jia L | 2009 | Planta Med2009，75，1： | 1 |
| 18 | A novel two-dimensional mixed molybdenum-vanadium polyoxometalate: Synthesis, magnetic property and characterization of ( H3O ) 2 显示文摘 | DAI L M MA Y WANG E B | 2007 | J Mol Struct2007，829，： | 1 |
| 19 | Gold( I ) catalysis:Selective synthesis of six- or seven-membered heterocycles from epoxy al- kynes显示文摘 | Dai L Shi M | 2009 | Eur J Org Chem2009，，： | 1 |
| 20 | Dendroclimatic analysis of Bet?ula ermanii forests at their upper limit of distribution in ChangbaiMountain, Northeast China显示文摘 | Yu D P Wang G G Dai L M | 2007 | Forest Ecol Manag2007，240，13： | 1 |
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