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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Characterization of poly(dimethylacrylamide) and the combination of poly(vinyl alcohol) and cetyltrimethylammonium bromide as dynamic electroosmotic flow suppression agents in capillary electrophoresis显示文摘 | Damin F Reijenga J C | 1998 | J Chromatogr A1998，817，： | 1 |
| 3 | Measuring the eco-efficiency of cement use 显示文摘 | Damineli B L Kemeid F M Aguiar P S | 2010 | Cement & Concrete Composites2010，32，： | 1 |
| 4 | New adsorbed coatings for capillary electrophoresis显示文摘 | CHIARI M CRETICH M DAMIN F | 2000 | Electrophoresis2000，21，： | 1 |
| 5 | Fetal DNA in maternal plasma: a noninvasive tool for prenatal diagnosis of beta- thalassemia显示文摘 | Galbiati S Brisci A Damin F | 2012 | Expert Opin Biol Ther2012，12，1： | 1 |
| 6 | Photolithographic bio-patterning of magnetic sensors for biomolecular recognition显示文摘 | Albisetti E Petti D Damin F | 2014 | Sensors and Actuators B2014，200，： | 1 |
| 7 | Effect of interaction with H2O and NH3 on the vibrational, electronic, and en-ergetic peculiarities of Ti (IV) centers of TS-1 catalysts: A spectroscopic and computational study显示文摘 | Bordiga S Damin A Bonino F | 2002 | J Phys Chem B2002，106，38： | 1 |
| 8 | Dimethyl Carbonate in the Supercages of NaY Zeolite:The Role Local Fields in Promoting Methylation and Carboxymethylationactivity显示文摘 | Bonino F Damin A Bordiga S | 2005 | Angew Chem Int Ed2005，44，： | 1 |
| 9 | Resonance Raman effects in TS-I: The structure of Ti (IV) species and re-activity towards H2O, NH3 and H2O2: an in situ study显示文摘 | Bordiga S Damin A Bonino F | 2003 | Phys Chem Chem Phys2003，5，： | 1 |
| 10 | The structure of the peroxo species in the TS-1 catalyst as investigated by reso-nant Raman spectroscopy显示文摘 | Bordiga S Damin A Bonino F | 2002 | Angewandte Chemie2002，114，24： | 1 |
| 11 | Ti-peroxo species in the TS-1/H2O2/H2O system显示文摘 | Bonino F Damin A Ricchiardi G | 2004 | J Phys Chem B2004，108，11： | 1 |
| 12 | Reactivity of Ti (IV) species hosted in TS-1 towards H2O2-H2O solutions investigated by ab initio cluster and periodic approaches combined with experimental XANES and EXAFS data:A review and new highlights显示文摘 | Bordiga S Bonino F Damin A | 2007 | Phys Chem Chem Phys2007，9，： | 1 |
| 13 | Fetal DNA in maternal plasma: A noninvasive tool for prenatal diagnosis of beta - thalassemia 显示文摘 | Galbiati S Brisci A Damin F | 2012 | Ex- pert Opin Biol Ther2012，12，1： | 1 |
| 14 | Reactivity of Ti(Ⅳ) species hosted in TS-1 towards H2O2-HzO solutions investiga- ted by ab initio cluster and periodic approaches combined with experimental XANES and EXAFS data = A review and new high- lights显示文摘 | BORDIGA S BONINO F DAMIN A | 2007 | Phys Chem Chem Phys2007，9，： | 1 |
| 15 | Effect of interaction with H2O and NHa on the vibrational, electronic, and energetic peculiarities of Ti( Ⅳ ) centers TS-1 catalysts = A spectroscopic and computational study显示文摘 | BORDIGA S DAMIN A BONINO F | 2002 | J Phys Chem B2002，106，38： | 1 |
| 16 | Fetal DNA in maternal plasma:a noninvasive tool for prenatal diagnosis of beta - thalassemia 显示文摘 | Galbiati S Brisci A Damin F | 2012 | Ex- pert Opin Biol Ther2012，12，1： | 1 |
| 17 | Fetal DNA in maternal plasma: a noninvasive tool for prenatal diagnosis of beta-thalassemia 显示文摘 | Galbiati S Brisci A Damin F | 2012 | Expert Opin BioI Ther2012，12，1： | 1 |
| 18 | Ti- peroxo species in the TS-1/H2 ()z/H20 system显示文摘 | BONINO F DAMIN A RICCHIARDI G | 2004 | The Journal of Physical Chemistry B2004，108，11： | 1 |
| 19 | Dimethyl carbonate in the supercages of NaY zeiolite: The role of local fields in promoting methylation and carboxymethylation activity显示文摘 | BONINO F DAMIN A BORDIGA S | 2005 | Angew Chem Int Ed2005，44，30： | 1 |
| 20 | Effect of interaction with H 2 O and NH 3 on the vibrational,electronic,and energetic peculiarities of Ti(Ⅳ) centers TS-1 catalysts:βA spectroscopic and computational study显示文摘 | Bordiga S Damin A Bonino F | 2002 | J Phys Chem B2002，106，38： | 1 |
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