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| 1 | Fatty liver disease in severe obese patients:Diagnostic value of abdominal ultrasound显示文摘AIM:To evaluate the sensitivity and specificity of abdominal ultrasound (US) for the diagnosis of hepatic steatosis in severe obese subjects and its relation to histological grade of steatosis. METHODS: A consecutive series of obese patients, who underwent bariatric surgery from October 2004 to May 2005, was selected. Ultrasonography was performed in all patients as part of routine preoperative time and an intraoperative wedge biopsy was obtained at the beginning of the bariatric surgery. The US and histological findings of steatosis were compared, considering histology as the gold standard. RESULTS: The study included 105 patients. The mean age was 37.2 ± 10.6 years and 75.2% were female. The histological prevalence of steatosis was 89.5%. The sensitivity and specificity of US in the diagnosis of hepatic steatosis were, respectively, 64.9% (95% CI: 54.9-74.3) and 90.9% (95% CI: 57.1-99.5). The positive predictive value and negative predictive value were, respectively, 98.4% (95% CI: 90.2-99.9) and 23.3% (95% CI: 12.3-39.0). The presence of steatosis onUS was associated to advanced grades of steatosis on histology (P = 0.016). CONCLUSION: Preoperative abdominal US in our series has not shown to be an accurate method for the diagnosis of hepatic steatosis in severe obese patients. Until another non-invasive method demonstrates better sensitivity and specificity values, histological evaluation may be recommended to these patients undergoing bariatric surgery. | Alessandro de Moura Almeida Helma Pinchemel Cotrim Daniel Batista Valente Barbosa Luciana Gordilho Matteoni de Athayde Adimeia Souza Santos Almir Galvo Vieira Bitencourt Luiz Antonio Rodrigues de Freitas Adriano Rios Erivaldo Alves | 2008 | World Journal of Gastroenterology2008，14，9： | 10 |
| 2 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 3 | Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease显示文摘This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. | Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana | 2023 | Neural Regeneration Research2023，18，12： | 2 |
| 4 | Recovery of phenol from aqueous solutions using liquid membranes with cyanex 923显示文摘 | Reis M T A De freitas O M Ismael M R C | 2007 | J Membrane Sci2007，305，1： | 1 |
| 5 | Adsorption of Cu(II), Cd(II), and Pb(II)from aqueous single metal solutions by cellulose and mercerized cellulose chemically modified with succinic anhydride显示文摘 | GURGEL L V A JNIOR O K DE FREITAS GIL R P | 2008 | Bioresource Technology2008，99，8： | 1 |
| 6 | Histamine H2 Receptor Signaling in the Pathogenesis of Sepsis: Studies in a Murine Diabetes Model显示文摘 | Daniela Carlos Fernando Spiller Fabrício O. Souto Silvia C. Trevelin Vanessa F. Borges Andressa de Freitas José C. Alves-Filho Jo?o S. Silva Bernhard Ryffel Fernando Q. Cunha | 2013 | The Journal of Immunology2013，，3： | 1 |
| 7 | Characterization of protein hydrolysates prepared for enteral nutrition显示文摘 | de Freitas O Padovan G J Vilela L | 1993 | Agric Food Chem1993，41，： | 1 |
| 8 | Management of dens invaginatus type III with large periradicular lesion 显示文摘 | Falcao Lde S de Freitas P S Marreiro Rde O | 2012 | J Contemp Dent Pract2012，13，1： | 1 |
| 9 | Development of a colorimetric system for evaluation of the masticatory efficiency 显示文摘 | Escudeiro Santos C de Freitas O Cropanese Spadaro AC | 2006 | Braz Dent J2006，17，2： | 1 |
| 10 | PCR multiplex for detection of Salmonella Enteritidis, Typhi and Typhimurium and occurrence in poultry meat显示文摘 | Camila Guimar?es de Freitas ?ngela Patrícia Santana Patrícia Helena Caldeira da Silva Vítor Salvador Pic?o Gon?alves Márcia de Aguiar Ferreira Barros Fernando Araripe Gon?alves Torres Luci Sayori Murata Simone Perecmanis | 2010 | International Journal of Food Microbiology2010，，1： | 1 |
| 11 | High-performance inulin and oligofructose prebiotics increase the intestinal absorption of iron in rats with iron deficiency anaemia during the growth phase显示文摘 | Freitas K D C Amancio O M S de Morais M B | 2012 | British Journal of Nutrition2012，108，06： | 1 |
| 12 | Adsorption of Cu(11), Cd(11), and Pb(11) from aqueous single metal solutions by mercerized cellulose and mercerized sugarcane bagasse chemically modified with EDTA dianhydride ( EDTAD ) 显示文摘 | Jt~nior O K Gurgel L V A de Freitas R P | 2009 | Carbohydrate Polymers2009，77，3： | 1 |
| 13 | Endoscopic retrograde cholangiopancreatography drainage for palliation of malignant hilar biliary obstruction——stent-in-stent or side-by-side?A systematic review and meta-analysis显示文摘BACKGROUND Biliary drainage,either by the stent-in-stent(SIS)or side-by-side(SBS)technique,is often required when treating a malignant hilar biliary obstruction(MHBO).Both methods differ from each other and have distinct advantages.AIM To compare both techniques regarding their efficacy and safety in achieving drainage of MHBO.METHODS A comprehensive search of multiple electronic databases(MEDLINE,Embase,LILACS,BIREME,Cochrane)was conducted and grey literature from their inception until December 2020 with no restrictions regarding the year of publication or language,since there was at least an abstract in English.The included studies compared SIS and SBS techniques through endoscopic retrograde cholangiopancreatography.Outcomes analyzed included technical and clinical success,early and late adverse events(AEs),stent patency,reintervention,and procedure-related mortality.RESULTS Four cohort studies and one randomized controlled trial evaluating a total of 250 patients(127 in the SIS group and 123 in the SBS group)were included in this study.There were no statistically significant differences between the two groups concerning the evaluated outcomes,except for stent patency,which was higher in the SIS compared with the SBS technique[mean difference(d)=33.31;95%confidence interval:9.73 to 56.90,I2=45%,P=0.006].CONCLUSION The SIS method showed superior stent patency when compared to SBS for achieving bilateral drainage in MHBO.Both techniques are equivalent in terms of technical success,clinical success,rates of both early and late AEs,reintervention,and procedure-related mortality. | Gabriel Mayo Vieira de Souza Igor Braga Ribeiro Mateus Pereira Funari Diogo Turiani Hourneaux de Moura Maria Vitória Cury Vieira Scatimburgo João Remíde Freitas Júnior Sergio A Sánchez-Luna Renato Baracat Eduardo Turiani Hourneaux de Moura Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura | 2021 | World Journal of Hepatology2021，13，5： | 1 |
| 14 | Enhancing and sustaining the topical ocular delivery of fluconazole using chi- tosan solution and poloxamer/chitosan in situ forming gel显示文摘 | Gratieri T Gelfuso GM de Freitas O | 2011 | Eur J Pharm Biopharm2011，79，2： | 1 |
| 15 | Fractionation of red wine polyphenols by solid-phase extraction and liquid chromatography显示文摘 | Baoshan Sun M. Concei??o Leandro Victor de Freitas M. Isabel Spranger | 2006 | Journal of Chromatography A2006，，1： | 1 |
| 16 | Litterfall dynamics and soil carbon and nitrogen stocks in the Brazilian palm swamp ecosystems显示文摘Background: This study aimed to determine the litterfall production, accumulation, decomposition rate and nutrient stocks, and to estimate the soil carbon(C) and nitrogen(N) stocks in three palm swamp ecosystems with different land use intensities in the Southeast of Brazil.Methods: Three palm swamp ecosystems with different land use intensities were evaluated: Agua Doce(AD),conserved area;Capivara(CV), area with small agricultural practices;and Buriti Grosso(BG), area with an intensive land use. Produced and accumulated litterfall from the Cerrado areas surrounding the palm swamps were collected from October 2014 to September 2015, and the Ca, Mg, K, and P concentrations were determined in the dry and rainy seasons. Soil samples were collected in the surrounding Cerrado and within the palm swamps until 100 cm soil depth to determine bulk density and soil C and N contents and stocks.Results: Annual litterfall production in the Cerrado surrounding palm swamps was similar in AD(3.58 Mg·ha^-1·year^-1) and CV(3.79 Mg·ha^-1·year^-1), and was lower in BG(2.84 Mg·ha^-1·year^-1), and was more intense during the dry season. Furthermore, litterfall accumulation was higher in CV(7.12 Mg·ha^-1·year^-1) and BG(6.75 Mg·ha^-1·year^-1), culminating in lower decomposition rates. AD showed the highest decomposition rate(0.60) due to its vegetation structure and conservation. The macronutrient contents from the production and accumulated litterfall had a low influence of the land use, decreasing in the following order: Ca > K > Mg > P. Soils in CV and BG palm swamp areas showed higher values of C and N contents, due to the use of land for agricultural crops and cattle raising in an extensive(rangeland) system. The BG palm swamp, showed the highest C(124.03 Mg·ha^-1) and N(10.54 Mg·ha^-1) stocks due to the land use history with different agricultural practices over time.Conclusions: The litterfall dynamics in the Cerrado surrounding palm swamps was more affected by climatic variables than the intensity of land use, but the litter decomposition was more accelerated in the conserved area.Anthropic interventions with soil organic matter(SOM) inputs contributed to an increase in soil C and N stocks in the palm swamp ecosystems. | Gracielle de Brito Sales Taynan Aquilles Marinho Lessa Daniela Aparecida Freitas Maria das Dores Magalhães Veloso Maria Ligia de Souza Silva Luiz Arnaldo Fernandes Leidivan Almeida Frazão | 2020 | Forest Ecosystems2020，7，3： | 1 |
| 17 | Recovery of phenol from aqueous solutions using liquid membranes with cyanex 923显示文摘 | Reis M TA Freitas de O M F Ismael M R C | 2007 | Journal of Membrane Science2007，305，12： | 1 |
| 18 | High-performance inulin and oligofructose prebiotics increase the intestinal absorption of iron in rats with iron deficiency anaemia during the growth phase 显示文摘 | FREITAS K C AMANCIO O M S DE MORAIS M B | 2012 | Br J Nut2012，108，6： | 1 |
| 19 | Femoral tunnel enlargement after anterior cruciate ligament re- construction using RigidFix compared with extracortical fixation显示文摘 | LOPES O V Jr DE FREITAS SPINELLI L LEITE L H | 2015 | Knee Surg Sports Traumatol Arthrosc2015，112，2： | 1 |
| 20 | Enhan- cing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan in situ forming gel 显示文摘 | GRATIERI T GELFUSO G M DE FREITAS O | 2011 | Eur J Pharm Biopharm2011，79，2： | 1 |
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