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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Misdiagnosis of tuberculosis and the clinical relevance of nontuberculous mycobacteria in Zambia显示文摘Objective:To determine the accuracy of TB diagnosis of TB in Zambia in the era of increasing HIV prevalence.Methods:Sputum of the clinically diagnosed TB cases was additionally subjected to liquid culture and molecular identification.This study distinguished between TB cases confirmed by positive Mycobacterium tuberculosis(M.tuberculosis) cultures and mycobacterial disease caused by non-tuberculous mycobacteria(NTM).Results:Only 49% of the 173 presumptively diagnosed TB cases was M.tuberculosis cultured,while in 13% (22) cases,a combination of M.tuberculosis and NTM was found.In 18% of the patients only NTM were cultured.In 28% ,no mycobacteria was cultivable.HIV positive status was correlated with the isolation of NTM(P<0.05).Conclusions:The diagnosis of tuberculosis based on symptoms, sputum smear and/or chest X-ray leads to significant numbers of false-positive TB cases in Zambia,most likely due to the increased prevalence of HIV.The role of NTM in tuberculosislike disease also seems relevant to the false diagnosis of TB in Zambia. | Patricia CAM Buijtels Michael D Iseman Shelagh Parkinson Cas S de Graaff Henri A Verbrugh Pieter LC Petit Dick van Soolingen | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 2 |
| 3 | Neural correlates of cognitive impairment in posterior cortical atrophy显示文摘 | Kas A de Souza LC Samri D | 2011 | Brain2011，134，： | 1 |
| 4 | ACTH-dependent pre- cocious pseudopuberty in an infant with DAX1 gene muta- tion 显示文摘 | Yeste D Gonz LC Prez de NG | 2009 | Eur J Pediatr2009，168，1： | 1 |
| 5 | Dete- rmination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia 显示文摘 | De Figueiredo-Pontes LL Pintao MC Oliveira LC et d | 2008 | Cytometry Part B Clin Cytom2008，74，3： | 1 |
| 6 | Mediterranean diet,lifestyle factors,and 10-year mortality in elderly European men and women:the HALE project显示文摘 | Knoops KT de Groot LC Kromhout D | | Journal of the American Medical Association0，，： | 1 |
| 7 | Ensemble methods for spoken emotion recognition in call-centres 显示文摘 | Morrison D Wang R De Silva LC | 2007 | Speech Communication2007，49，2： | 1 |
| 8 | Neural correlates ofcognitive impairment in posterior cortical atrophy 显示文摘 | Kas A de Souza LC Samri D | 2011 | Brain2011，134，5： | 1 |
| 9 | Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project 显示文摘 | Knoops KT de Groot LC Kromhout D Perrin AE Moreiras- Varela O | 2004 | JAMA2004，292，： | 1 |
| 10 | Surface electromyography: detec- tion and recording 显示文摘 | DE LC D CARLO J | 2002 | DelSys Incorporated2002，，10： | 1 |
| 11 | Early detectioin of intrauterine pregnancy with ultrasound显示文摘 | de Crespigny LC Cooper D Mckenna M | | 0，，01： | 1 |
| 12 | Mediterranean diet,lifestyle factors,and 10-year mortality in elderly European men and women:the HALE project显示文摘 | Knoops KT de Groot LC Kromhout D | | 0，，12： | 1 |
| 13 | Mediterranean di- et, lifestyle factors, and lO-year mortality in elderly European men and women: the HALE project 显示文摘 | Knoops KT de Groot LC Kromhout D | 2004 | JAMA2004，292，12： | 1 |
| 14 | Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage : associations with degenerative changes 显示文摘 | Tetlow LC Adlam D J Woolley DE | 2001 | Arthritis Rheum2001，44，3： | 1 |
| 15 | Shear stress affects the intracellular distribution of eNOS:direct demonstration by a novel in vivo technique显示文摘 | Cheng C van Haperen R de Waard M van Damme LC Tempel D Hanemaaijer L | 2005 | Blood2005，106，12： | 1 |
| 16 | Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage:associations with degenera- tive changes显示文摘 | Tetlow LC Adlam D J Woolley DE | 2001 | Arthritis Rheum2001，44，3： | 1 |
| 17 | Matria metalloproteinase and prointtammatory cytokine production by chondrocytes of human osteoarthritic cartilage : associations with degenerative chanhes显示文摘 | Tetlow LC Adlam D J Woolley DE | 2001 | Arthritis Rheum2001，44，3： | 1 |
| 18 | 补充维生素D、ω-3脂肪酸或力量训练运动项目对老年人临床结局的影响:DO-HEALTH随机临床试验显示文摘维生素D、ω-3脂肪酸和运动对疾病预防的获益仍不明确。该研究旨在评估维生素D、ω-3脂肪酸和力量训练运动项目单独或联合进行是否可改善老年人6种健康结局。设计、设置和参与者:该试验为双盲、安慰剂对照、2×2×2阶乘随机临床试验,纳入年龄≥70岁的老年人2 157例,参与者纳入时5年内无主要健康事件,有足够的运动能力和良好的认知状况。主要结局和检测指标:6种主要结局为3年间收缩压、舒张压、简易体能状况量表(short physical performance battery,SPPB)、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、非脊柱骨折及感染的发生率。结果:2 157例随机参与者(平均年龄74.9岁,61.7%为女性)中,1 900例(88%)完成研究。 | 袁源(摘译) 练桂丽(审校) Bischoff-Ferrari HA Vellas B Rizzoli R Kressig RW daSilva JAP Blauth M Felson DT McCloskey EV Watzl B Hofbauer LC Felsenberg D Willett WC Dawson-Hughes B Manson JE Siebert U Theiler R Staehelin HB de Godoi Rezende Costa Molino C Chocano-Bedoya PO Abderhalden LA Egli A Kanis JA Orav EJ DO-HEALTH Research Group | 2021 | 中华高血压杂志2021，29，1： | 0 |
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