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| 1 | A review on phospholipids and their main applications in drug delivery systems显示文摘Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity.These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of applications in drug delivery systems.The aim of this review is to summarize phospholipids and some of their related applications in drug delivery systems,and highlight the relationship between the properties and applications,and the effect of the species of phospholipids on the efficiency of drug delivery.We refer to some relevant literatures,starting from the structures,main sources and properties of phospholipids to introduce their applications in drug delivery systems.The present article focuses on introducing five types of carriers based on phospholipids,including liposomes,intravenous lipid emulsions,micelles,drug-phospholipids complexes and cochleates. | Jing Li Xuling Wang Ting Zhang Chunling Wang Zhenjun Huang Xiang Luo Yihui Deng | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 23 |
| 2 | Progress involving new techniques for liposome preparation显示文摘The article presents a review of new techniques being used for the preparation of liposomes.A total of 28 publications were examined.In addition to the theories,characteristics and problems associated with traditional methods,the advantages and drawbacks of the latest techniques were reviewed.In the light of developments in many relevant areas,a variety of new techniques are being used for liposome preparation and each of these new technique has particular advantages over conventional preparation methods.However,there are still some problems associated with these new techniques that could hinder their applications and further improvements are needed.Generally speaking,due to the introduction of these latest techniques,liposome preparation is now an improved procedure.These applications promote not only advances in liposome research but also the methods for their production on an industrial scale. | Zhenjun Huang Xuan Li Ting Zhang Yanzhi Song Zhennan She Jing Li Yihui Deng | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，4： | 7 |
| 3 | Arsenic trioxide encapsulated liposomes prepared via copper acetate gradient loading method and its antitumor efficiency显示文摘In this study, arsenic trioxide(ATO) was encapsulated in liposomes via copper acetate(Cu(OAc)2) gradients and high entrapment efficiency of over 80% was obtained. The average particle size and the zeta-potential of the liposomes were detected to be 115.1 ± 29.1 nm and-21.97 ± 0.6 m V, respectively. The TEM images showed rod-like precipitates in the inner aqueous phase, which was supposed be due to the formation of insoluble ATO–Cu complex.The in vitro drug release of ATO–Cu liposomes exhibited a sustained release over 72 h, and the release rates decreased with the increase of the p H of release media. Pharmacokinetic and tissue distribution studies of ATO liposomes showed significantly reduced plasma clearance rate, increased AUC0–12h and T1/2, and improved tumor distribution of As compared to iv administration of ATO solution. The anti-tumor effect of ATO loaded liposomes to S180 tumor-bearing mice was significantly improved with a tumor inhibition rate of 61.2%,meanwhile the toxicity of encapsulated ATO was greatly decreased. In conclusion, ATO can be effectively encapsulated into liposomes by remote loading method via Cu(OAc)2 gradients;the co-administration of ATO and Cu(Ⅱ) via liposomal formulation may find wide applications in the treatment of various tumors. | Shaoning Wang Chunxiu Liu Cunyang Wang Jia Ma Hui Xu Jianbo Guo Yihui Deng | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 6 |
| 4 | Preparation of berberine hydrochloride long-circulating liposomes by ionophore A23187-mediated ZnSO_(4)gradient method显示文摘The aim of the study was to prepare berberine hydrochloride long-circulating liposomes and optimize the formulation and process parameters,and investigate the influence of different factors on the encapsulation efficiency.Berberine hydrochloride liposomes were prepared in response to a transmembrane ion gradient that was established by ionophore A23187.Free and liposomal drug were separated by cation exchange resin,and then the amount of intraliposomal berberine hydrochloride was determined by UV spectrophotometry.The optimized encapsulation efficiency of berberine hydrochloride liposomes was 94.3%2.1%when the drug-to-lipid ratio was 1:20,and the mean diameter was 146.9 nm3.2 nm.As a result,the ionophore A23187-mediated ZnSO_(4)gradient method was suitable for the preparation of berberine hydrochloride liposomes that we could get the desired encapsulation efficiency and drug loading. | Xiang Luo Jing Li Ligang Guo Xiaobo Cheng Ting Zhang Yihui Deng | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，4： | 5 |
| 5 | Phyto-phospholipid complexes(phytosomes): A novel strategy to improve the bioavailability of active constituents显示文摘Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly'phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes. | Mei Lu Qiujun Qiu Xiang Luo Xinrong Liu Jing Sun Cunyang Wang Xiangyun Lin Yihui Deng Yanzhi Song | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 4 |
| 6 | Application of sialic acid/polysialic acid in the drug delivery systems显示文摘The properties of modified biomaterial are gaining more and more importance in drug delivery systems.Sialic acid(SA)and polysialic acid(PSA)serve as endogenous substances,which are non-immunogenic and biodegradable.At the same time,SA modification of the drugs/carriers can enhance the uptake of tumor cell and retention in brain;PSA modifi-cation can reduce the immunogenicity of the proteins or polypeptides and increase circulation time of the modified drugs/carriers in the blood,thus achieving active targeting effect.These properties offer a variety of opportunities for applications in drug delivery systems.This article summarizes the biological functions of SA and PSA and presents the technologies of SA/PSA modified small molecule drugs,proteins and carriers in drug delivery systems. | Ting Zhang Zhennan She Zhenjun Huang Jing Li Xiang Luo Yihui Deng | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，2： | 4 |
| 7 | The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon显示文摘PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance(ABC) upon repeated administration, and the extent of ABC phenomenon on the cytotoxic drugs-containing PEGylated liposomes is related to the dose of the cytotoxic drugs.In this study, EPI served as a model cytotoxic drug, a hydrophilic surfactant molecule,monosialylganglioside(GM1) was chosen and modified on the liposomes together with PEG.It was shown that upon mixed modification, when GM1 contents reached 10% or 15% mol,the ABC phenomenon of the PEGylated liposomal EPI significantly reduced. We also found that GM1 played an important role in abrogating the ABC phenomenon in both the induction phase and the effectuation phase. The results suggested that GM1 incorporation unfortunately did not avoid occurrence of ABC phenomenon completely, but GM1 modification on PEGylated liposomes may provide a significant improvement in clinical practice of PEGylated liposomes. Further study must be necessary. | Ting Zhang Songlei Zhou Le Kang Xiang Luo Yang Liu Yanzhi Song Xinrong Liu Yihui Deng | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，2： | 3 |
| 8 | Effects of complement inhibition on the ABC phenomenon in rats显示文摘Researchers reported that intravenously injected PEGylated colloidal drug carriers lose their long-circulating characteristic and accumulated extensively in liver when they are administrated twice in the same animal with certain intervals. This phenomenon was referred to as the 'accelerated blood clearance(ABC) phenomenon'. Some former studies had found that complement-mediated phagocytosis, activated by antigen–antibody complex, was responsible for inducing the phenomenon. According to the theory, we have used cobra venom factor to deplete complement in vivo and to investigate the effect of complement inhibition on the ABC phenomenon. Rats were administered by injection of cobra venom factor solution to build up the model of complement exhaustion/inhibition, and the effect of the inhibition of complement on ABC phenomenon was carried out. It seemed that inhibition of complement didn’t affect the pharmacokinetic of the first infection. By contrast, in rats of which complement had been depleted, the second dose of PEGylated nanoemulsions showed enhanced circulation time compared with normal rats in a complement inhibition-independent manner, but the ABC phenomenon was not completely eliminated. It indicated that complement inhibition could certainly weaken the accelerated clearance;meanwhile, there were other factors causing the ABC effect.These findings provide novel insights into the attenuating of ABC phenomenon and lay foundation for further study of immune mechanism. | Lirong Wang Yuqing Su Xuling Wang Kaifan Liang Mengyang Liu Wenya Tang Yanzhi Song Xinrong Liu Yihui Deng | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，3： | 2 |
| 9 | Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex显示文摘Nattokinase(NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorrhagic risk from an intravenous injection of NK,nattokinase-tauroursodeoxycholate(NK-TUDCA) complex was prepared at different pH values and with different ratios of NK and TUDCA. When assessing survival time, survival state,tail injury, and the body weight of mice, it was found that the NK-TUDCA complex(NK: 10 k IU/ml; TUDCA: 10 mg/ml; pH 5.0) had a lower toxicity when administered at an NK dosage of 130 kIU/kg in the acute toxicity test and 13 kIU/kg in the repeated low-dose challenge. From the results of the in vitro thrombolytic test and characterization of NKTUDCA, we speculated that the delayed release of NK-TUDCA might be the main cause of toxicity reduction by the complex. This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK. | Rui Feng Jing Li Jiepeng Chen Lili Duan XinRong Liu Donghua Di Yihui Deng Yanzhi Song | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，2： | 2 |
| 10 | Zhuifeng tougu capsules (追风透骨胶囊) improve rheumatoid arthritis symptoms in rats by regulating the toll-like receptor 2/4-nuclear factor kappa-B signaling pathway显示文摘OBJECTIVE: To investigate the efficacy of Zhuifeng tougu capsules(追风透骨胶囊, ZFTG) in the treatment of rheumatoid arthritis(RA) in rats and study its mechanism, focusing on the toll-like receptor 2/4-nuclear factor kappa-B(TLR2/4-NF-κB) signaling pathway.METHODS: TypeⅡ collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-,and low-dose ZFTG groups. The methotrexate(MTX) control group was treated with the corresponding drug intervention for 28 d. The joint temperature, pain threshold, joint swelling degree, and arthritis index(AI) score were measured. The production of C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), and rheumatoid factors(RFs) in the blood was detected by enzyme-linked immunosorbent assay. The protein expression of TLR2, TLR4, and NF-κB in synovial tissues was detected by Western blotting, and the m RNA expression of TLR2, TLR4, and NF-κB was detected by real-time polymerase chain reaction.RESULTS: Compared with the model group, the joint temperature in each treatment group, the MTX control group, and MTX group recovered, the degree of foot swelling, pain threshold, AI score decreased, serum CRP, ESR, RF level and the levels of TLR2, TLR4, and NF-κB in synovial tissue were decreased(P < 0.05). Among them, the curative effect in the medium-dose and MTX groups was more evident(P < 0.01).CONCLUSION: ZFTG has a significant effect on RA in rats, and its mechanism may involve regulating CRP levels, the ESR, and RFs via the TLR2/4-NF-κB signaling pathway. | GONG Hui KUANG Gaoyan WU Yongrong LU Fangguo DENG Yihui HE Yanlin WANG Hengxin | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 2 |
| 11 | The anticancer efficacy of pixantrone-loaded liposomes decorated with sialic acid-octadecylamine conjugate显示文摘 | Zhennan She Ting Zhang Xuling Wang Xuan Li Yanzhi Song Xiaobo Cheng Zhenjun Huang Yihui Deng | 2014 | Biomaterials2014，，： | 2 |
| 12 | Integrative Monsoon Frontal Rainfall Experiment(IMFRE-I):A Mid-Term Review显示文摘The mei-yu season,typically occurring from mid-June to mid-July,on average,contributes to 32%of the annual precipitation over the Yangtze-Huai River Valley(YHRV)and represents one of the three heavy-rainfall periods in China.Here,we briefly review the large-scale background,synoptic pattern,moisture transport,and cloud and precipitation characteristics of the mei-yu frontal systems in the context of the ongoing Integrative Monsoon Frontal Rainfall Experiment(IMFRE)field campaign.Phase one of the campaign,IMFRE-I,was conducted from 10 June to 10 July 2018 in the middle reaches of the YHRV.Led by the Wuhan Institute of Heavy Rain(IHR)with primary support from the National Natural Science Foundation of China,IMFRE-I maximizes the use of our observational capacity enabled by a suite of ground-based and remote sensing instruments,most notably the IHR Mesoscale Heavy Rainfall Observing System(MHROS),including different wavelengths of radars,microwave radiometers,and disdrometers.The KA350(Shanxi King-Air)aircraft participating in the campaign is equipped with Ka-band cloud radar and different probes.The comprehensive datasets from both the MHROS and aircraft instruments are combined with available satellite observations and model simulations to answer the three scientific questions of IMFRE-I.Some highlights from a previously published special issue are included in this review,and we also briefly introduce the IMFRE-II field campaign,conducted during June-July 2020,where the focus was on the spatiotemporal evolutions of the mei-yu frontal systems over the middle and lower reaches of the YHRV. | Chunguang CUI Xiquan DONG Bin WANG Baike XI Yi DENG Yihui DING | 2021 | Advances in Atmospheric Sciences2021，38，3： | 2 |
| 13 | Lessmode optic fiber evanescent wave absorbing sensor:Parameter design for high sensitivity liquid detection显示文摘 | WU Yihui DENG Xiaohong LI Feng | | 0，，： | 1 |
| 14 | Esterase-catalyzed dePEGylation of pH-sensitive vesicles modified with cleavable PEG-lipid derivatives显示文摘 | Huan Xu Yihui Deng Dawei Chen Weiwei Hong Yi Lu Xiaohui Dong | 2008 | Journal of Controlled Release2008，，3： | 1 |
| 15 | Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B显示文摘 | Meixia Zhang Hongliang Zhang Chunyan Sun Xiaolei Shan Xiaolin Yang Jesse Li-Ling Yihui Deng | 2009 | Cancer Chemotherapy and Pharmacology2009，，4： | 1 |
| 16 | Less-mode optic fiber evanescent wave absorbing sensor: Parameter design for high sensitivity liquid detection显示文摘 | Yihui Wu Xiaohong Deng Feng Li Xuye Zhuang | 2006 | Sensors & Actuators: B Chemical2006，，1： | 1 |
| 17 | The accelerated blood clearance phenomenon of PEGylated nanoemulsion upon cross administration with nanoemulsions modified with polyglycerin显示文摘For investigating the accelerated blood clearance(ABC) phenomenon of polyglycerin modified nanoemulsions upon cross administration with polyethylene glycol(PEG) covered nanoemulsion, we used the 1,2-distea-royl-sn-glycero-3-phosphoethanolamine-npolyglycerine-610 and the 1,2-distearoyl-n-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000] as modify materials, the dialkylcarbocyanines as fluorescence indicator. Exhausted macrophages rat model was established and new material containing polycarboxyl structure was synthesized. The microplate reader and the in vivo optical imaging system were applied to measure the concentration of nanoemulsions in tissues.The results show that the first dose of polyglycerin modified nanoemulsion can induce the ABC phenomenon of the second dose of PEGylated nanoemulsion. With the increase in the amount of the surface polyglycerin, the extent of the ABC phenomenon decreases. Liver accumulation has positive relationship with the ABC phenomenon. Furthermore, kupffer cells in liver can get more immune information from polyhydroxy structure than polycarboxyl group in the modify compound. The results of our work imply that the polycarboxyl structure has advantages to eliminate the ABC phenomenon. | Yuqing Su Lirong Wang Kaifan Liang Mengyang Liu Xinrong Liu Yanzhi Song Yihui Deng | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，1： | 1 |
| 18 | Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B显示文摘 | Meixia Zhang Hongliang Zhang Chunyan Sun Xiaolei Shan Xiaolin Yang Jesse Li-Ling Yihui Deng | 2009 | Cancer Chemotherapy and Pharmacology2009，，4： | 1 |
| 19 | Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer显示文摘 | Tingyan Liu Meixia Zhang Hongliang Zhang Chunyan Sun Xiaolin Yang Yihui Deng Wenyue Ji | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 20 | Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes显示文摘Accelerated blood clearance(ABC) phenomenon is common in many PEGylated nanocarriers, whose mechanism has not been completely elucidated yet. In this study, the correlation between Kupffer cells(KCs) and ABC phenomenon has been studied by KCs-targeted liposomes inducing ABC phenomenon and KCs depletion. In other words, the 4-aminophenyl-α-D-mannopyranoside(APM) lipid derivative DSPE-PEG 2000-APM(DPM), and 4-aminophenyl-β-L-fucopyranoside(APF) lipid derivative DSPE-PEG 2000-APF(DPF) were conjugated and modified on alendronate sodium(AD) liposomes to specifically target and deplete KCs. The dualligand modified PEGylated liposomes(MFPL) showed stronger ability to damage KCs in vitro and in vivo, which also could indirectly illustrate that dual-ligand modification could better target KCs. Besides, the hepatic biodistribution and pharmacokinetics could directly prove that MFPL had a stronger targeting ability to KCs. In addition, in depletion rats, plasma concentration and splenic biodistribution of MFPL and PEGylated liposomes(PL) were significantly elevated and hepatic biodistribution was significantly reduced, which demonstrated that KCs played an important role on elimination of nanoparticles. What’s more, ABC phenomenon of the secondary injection of PL was stronger in KCs depletion rats than that in normal rats, which indicated that depletion of KCs prolonged the circulation of PL in the first injection repeatedly stimulating B-cells in the marginal region of the spleen and causing it to secrete more IgM antibodies. This could also illustrate that anti-PEG IgM takes up a major station compared with KCs. Most important of all, KCs-targeted liposomes could induce a stronger ABC phenomenon than PL in normal rats, which declared that based on the same IgM concentration, the more the KCs were stimulated, the stronger ABC phenomenon was induced. However, in depletion rats, this difference of ABC phenomenon between PL and MFPL could no more exist, further demonstrating that KCs could participate and play a certain role in the ABC phenomenon. | Chaoyang Lai Cong Li Mengyang Liu Qiujun Qiu Xiang Luo Xinrong Liu Ling Hu Yihui Deng Yanzhi Song | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 1 |
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