|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 2 | Study on Biogenic Amines in Various Dry Salted Fish Consumed in China显示文摘This study was carried out to investigate the biogenic amines(BAs), physicochemical property and microorganisms in dry salted fish, a traditional aquatic food consumed in China. Forty three samples of dry salted fish were gathered from retail and wholesale markets and manufacturers, which had been produced in various regions in China. Cadaverine(CAD) and putrescine(PUT) were quantitatively the most common biogenic amines. About 14% of the samples exceeded the histamine content standards established by the FDA and/or EU. The highest histamine content was found in Silver pomfret(Pampus argenteus)(347.79 mg kg^(-1)). Five of forty three samples exceeded the acceptable content of TYR(100 mg kg^(-1)), and 23.26% of dried-salted fish contained high contents of biogenic amines(above 600 mg kg^(-1)). In addition, species, regions, pickling processes and drying methods made the physicochemical property, microorganisms and biogenic amines in dry salted fish to be different to some extents. The total plate count(TPC) was much higher than that of total halophilic bacteria in all samples. The biogenic amines, physicochemical property and microbiological counts exhibited large variations among samples. Furthermore, no significant correlation between biogenic amines and physicochemical property and TPC was observed. This study indicated that dry salted fish may still present healthy risk for BAs, depending on the processing methods, storage conditions among others. | WU Yanyan CHEN Yufeng LI Laihao YANG Xianqing YANG Shaoling LIN Wanling ZHAO Yongqiang DENG Jianchao | 2016 | Journal of Ocean University of China2016，15，4： | 8 |
| 3 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 4 | Expert consensus on early childhood caries management显示文摘Early childhood caries(ECC)is a significant chronic disease of childhood and a rising public health burden worldwide.ECC may cause a higher risk of new caries lesions in both primary and permanent dentition,affecting lifelong oral health.The occurrence of ECC has been closely related to the core microbiome change in the oral cavity,which may be influenced by diet habits,oral health management,fluoride use,and dental manipulations.So,it is essential to improve parental oral health and awareness of health care,to establish a dental home at the early stage of childhood,and make an individualized caries management plan.Dental interventions according to the minimally invasive concept should be carried out to treat dental caries.This expert consensus mainly discusses the etiology of ECC,caries-risk assessment of children,prevention and treatment plan of ECC,aiming to achieve lifelong oral health. | Jing Zou Qin Du Lihong Ge Jun Wang Xiaojing Wang Yuqing Li Guangtai Song Wei Zhao Xu Chen Beizhan Jiang Yufeng Mei Yang Huang Shuli Deng Hongmei Zhang Yanhong Li Xuedong Zhou | 2022 | International Journal of Oral Science2022，14，3： | 5 |
| 5 | Geochemical characteristics and tectonic setting of the Tuerkubantao mafic-ultramafic intrusion in West Junggar,Xinjiang,China显示文摘Mineral chemistry,whole-rock major oxide,and trace element compositions have been determined for the Tuerkubantao mafic-ultramafic intrusion,in order to understand the early Paleozoic tectonic evolution of the West Junggar orogenic belt at the southern margin of the Central Asian orogenic belt.The Tuerkubantao mafic-ultramafic intrusion is a well-differentiated complex comprising peridotite,olivine pyroxenite,gabbro,and diorite.The ultramafic rocks are mostly seen in the central part of the intrusion and surrounded by mafic rocks.The Tuerkubantao intrusive rocks are characterized by enrichment of large ion lithophile elements and depleted high field strength elements relative to N-MORB.In addition,the Tuerkubantao intrusion displays relatively low Th/U and Nb/U(1.13—2.98 and 2.53—7.02,respectively) and high La/Nb and Ba/Nb(1.15—4.19 and 37.7—79.82,respectively).These features indicate that the primary magma of the intrusion was derived from partial melting of a previously metasomatized mantle source in a subduction setting.The trace element patterns of peridotites,gabbros,and diorite in the Tuerkubantao intrusion have sub-parallel trends,suggesting that the different rock types are related to each other by differentiation of the same primary magma.The intrusive contact between peridotite and gabbro clearly suggest that the Tuerkubantao is not a fragment of an ophiolite.However,the Tuerkubantao intrusion displays many similarities with Alaskan-type mafic-ultramafic intrusions along major sutures of Phanerozoic orogenic belts.Common features include their geodynamic setting,internal lithological zoning,and geochemistry.The striking similarities indicate that the middle Devonian Tuerkubantao intrusion likely formed in a subduction-related setting similar to that of the Alaskan-type intrusions.In combination with the Devonian magmatism and porphyry mineralization,we propose that subduction of the oceanic slab has widely existed in the expansive oceans during the Devonian around the Junggar block. | Yufeng Deng Feng Yuan Taofa Zhou Chao Xu Dayu Zhang Xuji Guo | 2015 | Geoscience Frontiers2015，6，2： | 4 |
| 6 | Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study显示文摘Methylphenidate (MPH) is one of the most commonly used stimulants for the treatment of attention deficit hyperactivity disorder (ADHD). Although several studies have evaluated the effects of MPH on human brain activation during specific cognitive tasks using functional magnetic resonance imaging (fMRI), few studies have focused on spontaneous brain activity. In the current study, we investigated the effect of MPH on the intra-regional synchronization of spontaneous brain activity during the resting state in 18 normal adult males. A handedness questionnaire and the Wechsler Adult Intelligence Scale were applied before medication, and a resting-state fMRI scan was obtained 1 h after medication (20 mg MPH or placebo, order counterbalanced between participants). We demonstrated that: (1) there were no significant differences in the performance of behavioral tasks between the MPH and placebo groups; (2) the left middle and superior temporal gyri had stronger MPH-related regional homogeneity (ReHo); and (3) the left lingual gyrus had weaker MPH-related ReHo. Our findings showed that the ReHo in some brain areas changes with MPH compared to placebo in normal adults, even though there are no behavioral differences. This method can be applied to patients with mental illness who may be treated with MPH, and be used to compare the difference between patients taking MPH and normal participants, to help reveal the mechanism of how MPH works. | Yihong Zhu Bin Gao Jianming Hua Weibo Liu Yichao Deng Lijie Zhang Biao Jiang Yufeng Zang | 2013 | Neuroscience Bulletin2013，29，1： | 4 |
| 7 | An ultrasound simulation method for carotid arteries with a wall structure of three membranes显示文摘Ultrasound simulation for carotid arteries is helpful to the performance assessments of vessel wall detection and signal processing methods by using ultrasound techniques.An ultrasound simulation method of carotid artery wall with a three-membrane structure is proposed in present study.According to the ultrasound speckle distributions varying with the shapes and densities of scatterer distributions,as well as the statistic results of the clinical images,the parameters of distributions,densities and intensities of scatterers for different kinds of tissues in the carotid artery phantoms are determined.Each region is acoustically characterized using FIELD II software to produce the radio frequency echo signals,from which ultrasound images are derived.The results based on 30 simulations show that the echo distributions of the intimae,mediae,adventitias and blood are consistent with the clinical ones.Moreover,compared with the results from the central frequency of 8 MHz,the mean measurements for thicknesses of the intima,media and adventitia membranes,as well as the lumen diameter from the simulation images based on 12 MHz are the same as the preset ones,and the maximum relative errors are the 4.01%,1.25%,0.04%and 0.15%,respectively.The simulation under this condition is more realistic. | HU Xiao ZHANG Yufeng GAO Lian CAI Guanghui JIA Zhiguo ZHANG Kexin DENG Li | 2015 | Chinese Journal of Acoustics2015，34，3： | 3 |
| 8 | Generation of Permian Ni-Cu Sulfide Deposits in the East Tianshan(NW China) by Syn-collisional Mantle Derived Magmatism显示文摘A series of Ni-Cu sulfide deposits hosted in Early Permian mafic-ultramafic complexes occur along the^500km long linear Huangshan-Jingerquan belt in the East Tianshan at the southern margin of the Central Asian Orogenic Belt(Fig.1)(Zhou et al.,2004;Song and Li,2009;Song et al.,2011;Qin et al.,2011;Deng et al.,2014).Questions for genetic link between these deposits and | SONG Xieyan CHEN Liemeng DENG Yufeng XIE Wei | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 3 |
| 9 | Decolourization of the azo dye Orange G in aqueous solution via a heterogeneous Fenton-like reaction catalysed by goethite显示文摘 | Honghai Wu Xiaowen Dou Dayi Deng Yufeng Guan Liguo Zhang Guangping He | 2012 | Environmental Technology2012，，14： | 2 |
| 10 | Identifying human body states by using a flexible integrated sensor显示文摘Flexible sensors are required to be lightweight,compatible with the skin,sufficiently sensitive,and easily integrated to extract various kinds of body vital signs during continuous healthcare monitoring in daily life.For this,a simple and low-cost flexible temperature and force sensor that uses only two carbon fiber beams as the sensing layer is reported in this work.This simple,flexible sensor can not only monitor skin temperature changes in real time but can also extract most pulse waves,including venous waves,from most parts of the human body.A pulse diagnostic glove containing three such flexible sensors was designed to simulate pulse diagnostic methods used in traditional Chinese medicine.Wearable equipment was also designed in which four flexible sensors were fixed onto different body parts(neck,chest,armpit,and fingertip)to simultaneously monitor body temperature,carotid pulse,fingertip artery pulse,and respiratory rate.Four important physiological indicators—body temperature(BT),blood pressure(BP),heart rate(HR),and respiratory rate(RR)—were extracted by the wearable equipment and analyzed to identify exercise,excited,tired,angry,and frightened body states. | Ying Jin Guoning Chen Kete Lao Songhui Li Yong Lu Yufeng Gan Zhundong Li Jiajia Hu Jingcheng Huang Jinxiu Wen Honggui Deng Min Yang Zhiming Chen Xiaoyan Hu Baowen Liang Jianyi Luo | 2020 | npj Flexible Electronics2020，4，1： | 2 |
| 11 | Thermogravimetric analysis and kinetic study on pyrolysis of representative medical waste composition 显示文摘 | Deng Na Zhang Yufeng Wang Yan | 2008 | Waste Management2008，28，9： | 1 |
| 12 | The buildup of dissolved solids in closed white water systems显示文摘 | Yufeng Xu Yulin Deng | 2004 | Tappi Journal2004，3，8： | 1 |
| 13 | A new pyrolysis technology and equipment for treatment of municipal household garbage and hospital waste显示文摘 | Zhang Yufeng Deng Na Ling Jihong | 2003 | Renew Energy2003，28，15： | 1 |
| 14 | Geochemistry and petrogenetic implications of a Late Devonian mafic-ultramafic intrusion at the southern margin of the Central Asian Orogenic Belt显示文摘 | Xie Wei Song Xieyan Deng Yufeng | 2012 | Lithos2012，，144145： | 1 |
| 15 | The buildup of dissolved solids in closed white water systems显示文摘 | Yufeng Xu Yulin Deng | 2004 | TAPPI Journal2004，3，8： | 1 |
| 16 | Molybdenite Re-Os,titanite and garnet U-Pb dating of the Magushan skarn Cu-Mo deposit,Xuancheng district,Middle-Lower Yangtze River Metallogenic Belt显示文摘The Magushan skarn Cu-Mo deposit is a representative example of the skarn mineralization occurring within the Xuancheng ore district of the Middle-Lower Yangtze River Metallogenic Belt of eastern China.The precise age of an ore deposit is important for understanding the timing of mineralization relative to other geological events in a region and to fully place the formation of a mineral deposit within the geological context of other processes that occur within the study area.Here,we present new molybdenite Re-Os and titanite and andradite garnet U-Pb ages for the Magushan deposit and use these data to outline possible approaches for identifying genetic relationships in geologically complex areas.The spatial and paragenetic relationships between the intrusions,alteration,and mineralization within the study area indicates that the formation of the Magushan deposit is genetically associated with the porphyritic granodiorite.However,this is not always the case,as some areas contain complexly zoned plutons with multiple phases of intrusion or mineralization may be distal from or may not have any clear spatial relationship to a pluton.This means that it may not be possible to determine whether the mineralization formed as a result of single or multiple magmatic/hydrothermal events.As such,the approaches presented in this study provide an approach that allows the identification of any geochronological relationships between mineralization and intrusive events in areas more complex than the study area.Previously published zircon U-Pb data for the mineralization-related porphyritic granodiorite in this area yielded an age of 134.2±1.2 Ma(MSWD=1.4)whereas the Re-Os dating of molybdenite from the study area yielded an isochron age of 137.7±2.5 Ma(MSWD=0.43).The timing of the mineralizing event in the study area was further examined by the dating of magmatic accessory titanite and skarn-related andradite garnet,yielding U-Pb ages of 136.3±2.5 Ma(MSWD=3.2)and 135.9±2.7 Ma(MSWD=2.5),respectively.The dating of magmatic and hydrothermal activity within the Magushan area yields ages around 136 Ma,strongly suggesting that the mineralization in this area formed as a result of the emplacement of the intrusion.The dates presented in this study also provide the first indication of the timing of mineralization within the Xuancheng district.providing evidence of a close genetic relationship between the formation of the mineralization within the Xuancheng district and the Early Cretaceous magmatism that occurred in this area.This in turn suggests that other Early Cretaceous intrusive rocks within this region are likely to be associated with mineralization and should be considered highly prospective for future mineral exploration.This study also indicates that the dating of garnet and titanite can also provide reliable geochronological data and evidence of the timing of mineralization and magmatism,respectively,in areas lacking other dateable minerals(e.g.,molybdenite)or where the relationship between mineralization and magmatism is unclear,for example in areas with multiple stages of magmatism,with complexly zoned plutons,and with distal skarn mineralization. | Yue Li Feng Yuan Simon M.Jowitt Fangyue Wang Xiangling Li Yufeng Deng Yunyue Wang Taofa Zhou | 2021 | Geoscience Frontiers2021，12，3： | 1 |
| 17 | Geochemistry and petrogenetic implications of a Late Devonian mafic-ultramafic intrusion at the southern margin of the Central Asian Orogenic Belt显示文摘 | Xie Wei Song Xieyan Deng Yufeng | 2012 | Lithos2012，，： | 1 |
| 18 | A new pyrolysis technology and equipment for treatment of municipal household garbage and hospital waste 显示文摘 | Zhang Yufeng Deng Na Ling Jihong | 2003 | Renewable Energy2003，28，15： | 1 |
| 19 | Geochemistry and petrogenetic implications of a Late Devonian marie-ultramaifc intrusion at the southern margin of the Central Asian Orogenic Belt 显示文摘 | Xie Wei Song Xieyan Deng Yufeng | 2012 | Lithos2012，，： | 1 |
| 20 | A new pyrolysis technology and equipment for treatment of municipal household garbage and hospital waste 显示文摘 | ZHANG Yufeng DENG Na LING Jihong | 2003 | Renew Energy2003，28，15： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员