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| 1 | Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury显示文摘AIM: To examine complications associated with the use of therapeutic temperature modulation(mild hypothermia and normothermia) in patients with severe traumatic brain injury(TBI). METHODS: One hundred and fourteen charts were reviewed. Inclusion criteria were: severe TBI with Glasgow Coma Scale(GCS) < 9, intensive care unit(ICU) stay > 24 h and non-penetrating TBI. Patients were divided into two cohorts: the treatment group received therapeutic temperature modulation(TTM) with continuous surface cooling and indwelling bladder temperature probes. The control group received standard treatment with intermittent acetaminophen for fever. Information regarding complications during the time in the ICU was collected as follows: Pneumonia was identified using a combination of clinical and laboratory data. Pulmonary embolism, pneumothorax and deep venous thrombosis were identified based onimaging results. Cardiac arrhythmias and renal failure were extracted from the clinical documentation. acute respiratory distress syndrome and acute lung injury were determined based on chest imaging and arterial blood gas results. A logistic regression was conducted to predict hospital mortality and a multiple regression was used to assess number and type of clinical complications. RESULTS: One hundred and fourteen patients were included in the analysis(mean age = 41.4, SD = 19.1, 93 males), admitted to the Jackson Memorial Hospital Neuroscience ICU and Ryder Trauma Center(mean GCS = 4.67, range 3-9), were identified and included in the analysis. Method of injury included motor vehicle accident(n = 29), motor cycle crash(n = 220), blunt head trauma(n = 212), fall(n = 229), pedestrian hit by car(n = 216), and gunshot wound to the head(n = 27). Ethnicity was primarily Caucasian(n = 260), as well as Hispanic(n = 227) and African American(n = 223); four patients had unknown ethnicity. Patients received either TTM(43) or standard therapy(71). Within the TTM group eight patients were treated with normothermia after TBI and 35 patients were treated with hypothermia. A logistic regression predicting in hospital mortality with age, GCS, and TM demonstrated that GCS(Beta = 0.572, P < 0.01) and age(Beta =-0.029) but not temperature modulation(Beta = 0.797, ns) were significant predictors of in-hospital mortality [χ2(3) = 22.27, P < 0.01] A multiple regression predicting number of complications demonstrated that receiving TTM was the main contributor and was associated with a higher number of pulmonary complications(t =-3.425, P = 0.001). CONCLUSION: Exposure to TTM is associated with an increase in pulmonary complications. These findings support more attention to these complications in studies of TTM in TBI patients. | Kristine H O’Phelan Amedeo Merenda Katherine G Denny Kassandra E Zaila Cynthia Gonzalez | 2015 | World Journal of Critical Care Medicine2015，4，4： | 18 |
| 2 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Ethanol production by continuous fermentation - pervaporation: a preliminary economic analysis显示文摘 | Dennis J O' Brien Lorie H Roth Andrew J McAloon | 2000 | Journal of Membrane Science2000，166，： | 1 |
| 4 | Extracellular Matrix-Associated Serine Protease Inhibitors ( M r 33,000, 31,000, and 27,000) Are Single-Gene Products with Differential Glycosylation: cDNA Cloning of the 33-kDa Inhibitor Reveals Its Identity to Tissue Factor Pathway Inhibitor-2显示文摘 | C.N. Rao Prasad Reddy Yueying Liu Edel O’toole Dennis Reeder Donald C. Foster Walter Kisiel David T. Woodley | 1996 | Archives of Biochemistry and Biophysics1996，，1： | 1 |
| 5 | Improving Learning with eTextbooks显示文摘 | Dennis A R McNamara K O Morrone S | | 0，，： | 1 |
| 6 | New nitrate- based treatments control hydrogen sulfide in reservoirs 显示文摘 | HITZMAN D O DENNIS M | 2004 | World Oil2004，225，11： | 1 |
| 7 | Ethanol production by continuous fermentation-pervaporation: a preliminary economic analysis 显示文摘 | Dennis J O Brien Lorie H Roth Andrew J Mcaloon | 2000 | Journal of Membrane Science2000，166，： | 1 |
| 8 | Cloning of Pseudomonas aeruginosa algG, which controls alginate structure显示文摘 | Chaitanya E Dennis E O | 1990 | Journal of Bacteriology1990，172，6： | 1 |
| 9 | Gene expression microarrays: a 21st century tool for directed vaccine design显示文摘 | NEELAM D RUBEN B DENNIS O | 2002 | Vaccine2002，20，： | 1 |
| 10 | European Respiratory Society Guidelines on the use of nebulizers 显示文摘 | Boe J Dennis JH O'Driscoll BR | 2001 | Eur Respir J2001，18，1： | 1 |
| 11 | Occupational noise exposure and hearing loss of workers in two plants in Eastern Saudi Arabia显示文摘 | Ahmed HO Dennis JH Baderan O | 2001 | Ann Oceup Hyg2001，45，5： | 1 |
| 12 | Wind generation,power system operation,and emissions reduction显示文摘 | Denny E O'Malley M | | 0，，01： | 1 |
| 13 | Disturbance decoupled fault reconstruction using cascaded sliding mode observers显示文摘 | KOK Y N CHEE P T DENNY O | 2012 | Automatica2012，48，7： | 1 |
| 14 | Event-level analyses of energy drink consumption and alcohol intoxication in bar patrons显示文摘 | Dennis L. Thombs Ryan J. O’Mara Miranda Tsukamoto Matthew E. Rossheim Robert M. Weiler Michele L. Merves Bruce A. Goldberger | 2009 | Addictive Behaviors2009，，4： | 1 |
| 15 | Modeling the Effect of Backfills on U-Tube Ground Coil Performance显示文摘 | Dennis L Neai O | 1998 | ASHRAE Trans1998，104，2： | 1 |
| 16 | Reliability design and case study of a refrigerator compressor subjected to repetitive loads显示文摘 | Seong W Michael P Dennis L O | 2009 | International Journal of Refrigeration2009，32，3： | 1 |
| 17 | Posterior cruciate condylar total knee arthroplasty:Average 11-year follow-up evaluation显示文摘 | Dennis DA Clayton ML O Donnell S | 1992 | Clin Orthop1992，12，281： | 1 |
| 18 | Xenia includes metaxenia显示文摘 | Denny J O | 1992 | Hort Science1992，27，7： | 1 |
| 19 | Development of an equivalent diameter expression for vertical U-tubes used in ground-coupled heat pumps显示文摘 | GU YIAN DENNI L O' NEAL | 1998 | ASHRAE Transactions1998，104，2： | 1 |
| 20 | High-frequency(10-18kHz)hearing thresholds:reliability,and effects of age and occupational noise exposure显示文摘 | AHMED H O DENNIS J H BADRAN O | 2001 | Occup Med2001，51，： | 1 |
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