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77篇 您的检索式：作者名="DOBREVA"

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	题名	作者	年代	出处	被引量
1	Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment.	Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva	2019	Cell Research2019，29，6：	5
2	Activity of substrates in the catalyzed nucleation on glass-forming melts I Theory显示文摘	DOBREVA A GUTZOW I	1993	J Noncrystalline Solids1993，162，：	1
3	Activity of substrates in the catalyzed nucleation on glass-forming melts II Experimental evidence显示文摘	DOBREVA A GUTZOW I	1993	J Noncrystalline Soiids1993，162，：	1
4	SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression 显示文摘	Dobreva G Dambaeher J Grossehedl R	2003	Genes Dev2003，17，24：	1
5	Electroless deposition of diamond powder dispersed nickel-phosphorus coatings on steel substrate显示文摘	Petrova M Noncheva Z Dobreva E	2011	Trans Inst Met Finish2011，89，2：	1
6	A Non-isothermal Differential Scanning Calorimetry Method for the Determination of Specific Surface Energies in Polymer Crystals显示文摘	Gonzalez M Dobreva M A	1995	Thermochimica Acta1995，258，1：	1
7	Cholesterol is the major component of native lipoproteins activating the p38 mitogen-activated protein kinases显示文摘	Dobreva I Zschornig O Waeber G	2005	Biol Chem2005，386，9：	1
8	SUMO modification of a novel MAR-binding protein,SATB2,modulates immunoglobulin μ gene expression显示文摘	Dobreva G Dambacher J Grosschedl R	2003	Genes Dev2003，17，24：	1
9	Study off optimum conditions and kinetics off starch hydrolysis by means of thermostable α-amylase显示文摘	Yankov D Dobreva	1986	Enzyme Microb Technol1986，，8：	1
10	Kinetics of vitrification under hydrostatic pressure and under tangential stress 显示文摘	Dobreva A Russel C	1997	J Non-cryst Solids1997，215，23：	1
11	EBF2 regulates osteoblast-dependent differentiation of osteoclasts 显示文摘	Kieslinger M Folberth S Dobreva G	2005	Dev Cell2005，9，6：	1
12	SATB2 is a multifunctional determinant of craniofacial patterning and osteo- blast differentiation显示文摘	Dobreva G Chahrour M Dautzenberg M	2006	Cell2006，125，5：	1
13	Mapping the integrinlinked kinase interactome using SILAC 显示文摘	Dobreva I Fielding A Foster L J 	2008	J Proteome Res2008，7，4：	1
14	SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation显示文摘	Dobreva G Chahrour M Dautzenberg M	2006	Cell2006，125，9：	1
15	EBF2 regulates osteoblast-dependent differentiation of osteoclasts显示文摘	Kieslinger M Folberth S Dobreva G	2005	Dev Cell2005，9，6：	1
16	Electroless deposition of nanodisperse metal coatings on fabrics显示文摘	PETROVA M GEORGIEVA M DOBREVA E		0，，01：	1
17	Mapping the integrin-linked kinase interactome using SILAC显示文摘	Dobreva I Fielding A Foster LJ	2008	J Proteome Res2008，7，4：	1
18	Fraction snow cover mapping through artificial neural network analysis of MODIS surface reflectance显示文摘	Dobreva I D Klein A G	2011	Remote Sensing of Environment2011，115，12：	1
19	EBF2 regulates osteoblast-dependent differentiation of osteoclasts显示文摘	Kieslinger M Folberth S Dobreva G	2005	Dev Cell2005，9，：	1
20	Performance of magnetically stabilized bed reactor with immobilized yeast cells显示文摘	IVANOVA V HRISTOV J DOBREVA E	1996	Appl Biochem Biotechnol1996，59，：	1

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