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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 3 | Gray-scale masks for diffractive-optics fabrication:Ⅱ Spatially filtered halftone screens 显示文摘 | DONALD C O WILLIE S R | 1995 | Appl Opt1995，34，32： | 2 |
| 4 | The Quality of Life (QOL) Research Movement: Past, Present, and Future显示文摘 | Sirgy M A C michalos A L Ferriss R Easterlin Donald Patrick William Pavot | 2006 | Social Indicators Research2006，76，： | 1 |
| 5 | Paleoshoreline evidence for postglacial tilting in Southern Manitoba显示文摘 | Gary E T Donald R C Bruce G B | 1998 | Journal of Paleolin- nology1998，19，： | 1 |
| 6 | Adenosine inhibition of mcsopontinc cholincrgic neurons : implications for EEG arousal 显示文摘 | Donald G Rainnie Heinz C Grunze R W McCarley | 1994 | Science1994，263，5147： | 1 |
| 7 | Entrenched Knowledge Structures and Consumer Response to New Products 显示文摘 | Moreau C Page Donald R Lehman Arthur B Markman | 2001 | Journal of Marketing Research2001，38，2： | 1 |
| 8 | ‘SPC136’(Suite NoteTM)sweet cherry显示文摘 | Hampson C Mac Donald R Mc Kenzie DL | 2014 | Canadian Journal of Plant Science2014，94，8： | 1 |
| 9 | Fragmentation of rock under dynamic loads 显示文摘 | Donald A S Donald R C Lynn S | 1974 | International Journal of Rock Mechanics and Mining Science & Geomechanics Abstract1974，11，： | 1 |
| 10 | Plant diversity,soil microbial communities,and ecosystem function:Are there any links显示文摘 | Donald R Z Willame H David C W | 2003 | Ecology2003，84，8： | 1 |
| 11 | Distribution of the Bottom Simulating Reflector in the Offshore Taiwan Collision Zone 显示文摘 | Chi W C Donald L R Liu C S | 1998 | TAO1998，9，4： | 1 |
| 12 | Oncogenic role of engrailed-2 (EN2) in prostate cancer cell growth and survival 显示文摘 | Bose S K Bullard R S Donald C D | 2008 | Transl Oncogen2008，3，3： | 1 |
| 13 | A medium for the presunptive detection of Enterobacter sakazaki in infant formula 显示文摘 | Leuscher R C K Baird F Donald B | 2004 | Food Microbiol2004，21，： | 1 |
| 14 | Mass Spectrometry of Technetium at the Subpicogram Levelanal显示文摘 | Donald J R Norman C S Kurt W | 1990 | Anal Chem1990，62，： | 1 |
| 15 | Redox reaction involving hydrocarbons and mineral oxidant's: A mechanism for significant porosity enhancement in sandstones 显示文摘 | Surdam R C Crossey L J MacGowan Donald B | 1993 | AAPG Bull1993，77，9： | 1 |
| 16 | Association of median width and highway accident rates显示文摘 | Matthew K Forrest C Donald R | | 0，，： | 1 |
| 17 | Peri-Implant Mucositis and Peri-lmplantitis:A Current Understanding of Their Diagnoses and Clinical Implications显示文摘 | Paul R Donald C David C | 2013 | J Periodon tol2013，84，43： | 1 |
| 18 | Building effective international joint venture leadership teams in China显示文摘 | Jiatao Li Katherine R Xin Anne Tsui Donald C Hambrick | 1999 | Journal of World Business1999，，1： | 1 |
| 19 | Plant diversity, soil microbial communities, and ecosystem function: are there any links 显示文摘 | Donald R Z William E H David C W | 2003 | Ecology2003，84，8： | 1 |
| 20 | Foliage plants for removing indoor air pollution from energy efficient homes显示文摘 | WOLVERTON B C DONALD R C WATKINS E A | 1984 | Economic Botany1984，38，2： | 1 |
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