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| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | Residual stress measurement techniques 显示文摘 | DONNA W | 2001 | Advanced Materials & Process2001，159，8： | 1 |
| 3 | Activity of deep abdominal muscles increases during submaximal flexion and extension efforts but antagonist co-contraction remains unchanged显示文摘 | McCook Donna T Vicenzino Bill Hodges Paul W | 2009 | JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY2009，，19： | 1 |
| 4 | Cost allocation in manufacturing- remanufacturing operations 显示文摘 | Toktay L B Donna W | 2011 | Production and Operations Management2011，20，6： | 1 |
| 5 | Experimen -tal and analytical efforts to characterize cutting fluid mist forma-tion and behavior in machining 显示文摘 | Donna J Michalek Wilson W S Hii Jichao Sun | 2003 | Applied Occupational & Envi -ronmental Hygiene2003，18，11： | 1 |
| 6 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 7 | Psychiatric nurses thoughts and feelings aboutrestraint use a decision dilemma 显示文摘 | Sandy M Donna W | 2000 | Jounal of AdvancedNursing2000，31，2： | 1 |
| 8 | Variable Antigens of Ureaplasma Urealyticum Containing Both Serovar-Specific and Serovar-Cross-Reactive Epitopes显示文摘 | Harold L W Donna K B Gail H C | 1990 | Infect Immun1990，58，11： | 1 |
| 9 | Status of Newborn Screening Programs in the United States显示文摘 | Bradford LT Alissa J Donna W | 2006 | Diatrics2006，117，5： | 1 |
| 10 | Requirement for IL-13 independently of IL-4 in experimental asthma显示文摘 | Gabriele G Martha W Adil EW Rajeev V Frank B Donna MR | | 0，，： | 1 |
| 11 | Relationships of temperature and sodium chloride concentration to the survival of Vibrio parahemolyticusin broth and fish homogenate显示文摘 | Donna C Margy W | 1972 | Applied and Environmental Microbiology1972，23，2： | 1 |
| 12 | Airway remodeling in asthma:new insight 显示文摘 | Donna E Davies PHD James W | 2003 | J Allergy Clin Immunol2003，111，： | 1 |
| 13 | Psychiatric nurses' thoughts and feelings about restraint use:a decision dilemma显示文摘 | Sandy M Donna W | 2000 | J Advanced Nursing2000，31，2： | 1 |
| 14 | The prevalence and management of asthma in primary-aged schoolchildren in the south of England显示文摘 | DONNA M C JENNY M W HELEN C | 2002 | Health Educ Res2002，97，2： | 1 |
| 15 | Activity of Flurbiprofen and Chemically Related Anti-inflammatory Drugs in Models of Alzheimer's Disease显示文摘 | Laura G Ennio O Donna W | | 0，，02： | 1 |
| 16 | Comparing science efficacy beliefs of elementary education majors in integrated and non-integrated teacher education coursework显示文摘 | Kenneth P K Donna L W | | 0，，02： | 1 |
| 17 | Toward a theory of stakeholder identification and salience: defining the principle of who and what really counts 显示文摘 | Ronald K M Bradleg R A Donna J W | 1997 | The Academy of Management Review1997，，4： | 1 |
| 18 | C|orung reatriction fragments that promote expression of a gene in Bacillus subtilis 显示文摘 | Donna M W Elizabeth J D Paul S L | 1981 | J Bacte- rol1981，146，： | 1 |
| 19 | HIV Testing Frequency Among Men Who Have Sex With Men Attending Sexually Transmitted Disease Clinics: Implications for HIV Prevention and Surveillance显示文摘 | Donna J Helms Hillard S Weinstock Kristen C Mahle Kyle T Bernstein Bruce W Furness Charlotte K Kent Cornelis A Rietmeijer Akbar M Shahkolahi James P Hughes Matthew R Golden | 2009 | JAIDS Journal of Acquired Immune Deficiency Syndromes2009，，3： | 1 |
| 20 | Hypertension and arterial stiffness: the atherosclerosis risk in communities study显示文摘 | Donna K Arnett Lori L Boland Gregory W Evans Ward Riley Ralph Barnes H.A Tyroler Gerardo Heiss | 2000 | American Journal of Hypertension2000，，4： | 1 |
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