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113篇 您的检索式：作者名="DOUCET E"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Calcium intake,body composition,and lipoprotein- lipid concentrations in adults显示文摘	JACQMAIN M DOUCET E DESPRES J P BOUCHARD C	2003	American Journal of Clinical Nutrition2003，77，：	2
3	Inadequate sleep as a contributor toobesity and type 2 diabetes显示文摘	McNeil J Doucet E Chaput JP	2013	Can J Diabetes2013，37，2：	1
4	Subjective Identities and Identity Communication Processes in Information Technology Teams显示文摘	Thatcher S M B Doucet L Tuncel E	2003	Research on Managing Groups and Teams2003，，5：	1
5	Unchanged fasting and postprandial adiponectin levels following a 4 d caloric restriction in young healthy men 显示文摘	Pomerleau M Harper ME Doucet E	2004	Clin Endocrinol( Oxf)2004，60，4：	1
6	Mechanism of oedema in nephrotic syndrome old theories and new ideas显示文摘	Deschenes G Feraille E Doucet A	2003	Nephrol dial transplant2003，18，3：	1
7	Changes in energy ex-penditure and substrate oxidation resulting from weight loss inobese men and women: is there an important contribution of lep-tin? 显示文摘	Pierre SS Almeras N	2000	J Clin Endocrinol Metab2000，85，4：	1
8	Enzyme-induced gelation of extensively hydrolyzed whey proteins by alcalase: Comparison with the plastein reaction and characterization of interactions 显示文摘	Doucet D Gauthier S F Otter D E	2003	Journal of Agricultural and Food Chemistry2003，51，20：	1
9	Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods显示文摘	Yoshioka M Doucet E Drapeau V	2001	The British Journal of Nutrition2001，85，2：	1
10	Enzyme-induced gelation of extensively hydrolyzed whey proteins by alcalase: compari- son with the plastein reaction and characterization of interactions显示文摘	DOUCET D GAUTHIER S F OTTER D E	2003	Journal of Agricultural and Food Chemistry2003，51，20：	1
11	Improvement in insulinsensitivity by weight loss does not affect hyperinsulinemia-mediated re-duction in total and high molecular weight adiponectin:a MONETstudy显示文摘	Drapeau S Doucet E Rabasa-Lhoret R	2011	Appl Physiol Nutr Metab2011，36，2：	1
12	Enzyme-induced gela- tion of extensively hydrolyzed whey proteins by alcalase: Com- parison with the plastein reaction and characterization of interae- tions显示文摘	Doucet D Gauthier S F Otter D E	2003	Journal of Agricultural and Food Chemistry2003，51，20：	1
13	Advances in modif- ying and understanding whey protein functionality显示文摘	FOEGENDING E A DAVIS J P DOUCET D	2002	Trends Food Sci Tech2002，13，5：	1
14	New approach to radiation burn treatment by dosimetry-guided surgery combined with au- tologous mesenchymal stem cell therapy显示文摘	Lataillade JJ Doucet C Bey E	2007	Regen Med2007，2，5：	1
15	Dietary fat composi- tion and human adiposity 显示文摘	Doucet E Alm6ras N White MD	1998	Eur J Clin Nutr1998，52，1：	1
16	Enzyme-induced gelation of extensively hydrolyzed whey proteins by Pancreatin: comparison with the plastein reaction and characterization of interaction 显示文摘	Doucet D Gauthier S F Otter D E	2003	J Agric Food Chem2003，51，：	1
17	Which parameters differ in very old patients with chronic atrial fibrillation treated by anticoagulant or aspirin Antithrombotic treatment of atrial fibrillation in the elderly显示文摘	Doucet J Greboval-Furstenfeld E Tavildari A	2008	Fundam Clin Pharmacol2008，22，5：	1
18	Enzymatic-induced gelation of extensively hydrolyzed whey proteins by Alcalse:compafision with the plastein reaction and characterization of interactions显示文摘	DOUCET D GAUTHIER S F OTTER D E	2003	Journal of Agricultural and Food Chemistry2003，51，：	1
19	Calcium intake, body composition, and lipoprotein-lipid concentrations in adults 显示文摘	Jacqmain M Doucet E Despr's JP	2003	The American Journal of Clinical Nutrition2003，77，6：	1
20	Enzyme-induced gelation of extensively hydrolyzed whey proteins by alcalase:peptide identification and determination of enzyme specificity显示文摘	DOUCET D OTTER D E GAUTHIER S F	2003	J Agr Food Chem2003，，51：	1

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