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| 1 | Molecular mechanism of non-alcoholic fatty liver disease induced and aggravated by chronic stress through HSL/ATGL-FFA which promotes fat mobilization显示文摘Objective:To study the effects of social stress(CS)and social stress combined with high-fat diet on fat mobilization as a candidate mechanism for the induction or aggravation of non-alcoholic fatty liver disease(NAFLD).Methods:Thirty-two male Wistar rats(250±10 g)were randomly allocated to a blank control group(BC),a high-fat diet group(HFD),a CS group,and a combined CS and high-fat diet group(CS t HFD).Rats were sacrificed and tissues were collected after 8 weeks.Liver and body mass were measured and used to calculate the liver index.Serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),and free fatty acids(FFAs)were measured.Liver sections were examined microscopically after oil red O and hematoxylin and eosin staining.The relative mRNA expression of acetyl-CoA carboxylase(ACCase),hydroxymethylglutaryl coenzyme A(HMG-CoA)reductase in liver,and hormone-sensitive lipase(HSL),and adipose triglyceride lipase(ATGL)in subcutaneous adipose tissue,were measured by real-time PCR.The liver concentrations of triglyceride,reactive oxygen species,and ACCase were measured by ELISA and HSL activity was determined using turbidimetry.Results:NAFLD developed in the CS,HFD,and CS t HFD groups,with the most severe NAFLD being in the CS t HFD group.Serum AST,ALT,and FFA,liver index,and hepatic triglyceride,FFA,and tumor necrosis factor-a were significantly higher in both the CS and CS t HFD groups.However,food intake and ACCase mRNA expression were lower.The mRNA expression of HSL and ATGL in adipose tissue was much higher,and HSL activity was higher in the CS group than in the BC group,and in the CS t HFD group than in the HFD group.Conclusion:We have successfully established two models of stress-induced NAFLD,suggesting stress can induce and aggravate NAFLD by promoting fat mobilization through upregulation of HSL and ATGL. | Jie Mu Xueqian Wang Qingguo Wang Fafeng Cheng Wenxiang Zhu Changxiang Li Chongyang Ma Changming Zhai Yajun Lian Xin Du | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，4： | 2 |
| 2 | Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy显示文摘We developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugsconjugated polydopamine nanoparticles(PDOXCBs),which integrated near infrared(NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle.Upon a mild NIR irradiation(808 nm,1 W/cm^(2),10 min),PDOXCBs gradually heated aqueous solution over 12.8-13.9℃,which accordingly enhanced in vitro dual doxorubicin(DOX) and chlorambucil(CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L D,L-dithiothreitol(DTT).The combination photothermal-cocktail chemotherapy(PTT-CCT) treatment based on PDOXCB27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration(IC_(50)) of 2.23 μg/mL and a combination index of0.36,displaying a superior synergistic effect between PTT and CCT in vitro. | Lei Zhou Chang Du Rong Zhang Changming Dong | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 3 | Dual confinement of polysulfides in boron-doped porous carbon sphere/graphene hybrid for advanced Li-S batteries显示文摘由做硼的多孔的碳范围和 graphene (BPCS-G ) 组成的混合结构被设计了并且向解决 polysulfide 梭问题综合了,它是当前的 Li-S 电池的最关键的问题。显示出高表面区域的建议混合结构(870 m 2??????????????? ? €畧湡湩?? 挠瑹獯湩 ?????? ㄠ‰ ????????????? 吠 ?? €?‰ ??????? ‰ ?????????????????????????? ￡桴?? | Wei Ai Jiewei Li Zhuzhu Du Chenji Zou Hongfang Du Xin Xu Yu Chen Hongbo Zhang Jianfeng Zhao Changming Li Wei Huang Ting Yu | 2018 | Nano Research2018，11，9： | 2 |
| 4 | Plasma chemical degradation of phenol in solution by gas liquid gliding arc discharge显示文摘 | Yan Jianhua Du Changming Li Xiadong | 2005 | Plasma Sources Sci & Technol2005，14，： | 1 |
| 5 | FeVO 4 as a highly active heterogeneous Fenton-like catalyst towards the degradation of Orange II显示文摘 | Jingheng Deng Jingyuan Jiang Yuanyuan Zhang Xiaoping Lin Changming Du Ya Xiong | 2008 | Applied Catalysis B, Environmental2008，，3： | 1 |
| 6 | Decolorization of acid orange 7 solution by gas–liquid gliding arc discharge plasma 显示文摘 | Du Changming Shi Taihong Sun Yuwei | 2008 | Journal of Hazardous Materials2008，154，13： | 1 |
| 7 | Decomposition of toluene in a gliding arc discharge plasma reactor显示文摘 | DU Changming YAN Jianhua Cheron B | 2007 | Plasma Sources Science and Technology2007，16，： | 1 |
| 8 | Degradation of4-chlorophenol using agas-liquid gliding arc discharge plasma reactor显示文摘 | DU Changming YAN Jianhua Cheron B G | 2007 | Plasma Chemistry and Plasma Processing2007，27，： | 1 |
| 9 | Plasma pyrolysis and gasification of carambola leaves using non-thermal arc plasma显示文摘Soil pollution(heavy metals and organic matter)is becoming more and more serious,phytoremediation has rapidly become a highly important method to deal with this problem.Therefore,the treatment and disposal of hyperaccumulators have been a topic of concern.In this paper,carambola leaves are selected as feedstock considering that carambola is a potential hyperaccumulator.A series of tests were performed to discuss 6 main influencing factors on total gas yield and metal fixing using a non-thermal arc plasma setup,to investigate the feasibility of plasma treatment of hyperaccumulator and provide a new method to utilize the harvested hyperaccumulator.The maximum total gas yield reached approximately 85%at an airflow rate of 3 L/min,the processing time of 7 min,discharge power of 29.95 W with the addition of water(water:sample=1:1).A reducing or inert carrier gas or the addition of some specific inorganic additives at optimal conditions were in favor of increasing metal fixing efficiency.However,the effects of these factors usually have two sides,and some factors may have conflicting effects between gas yield and metal fixing,and.It is necessary to optimize these factors for achieving the desired goal.The obtained solid products exhibit the potential to fix metals and act as activated carbon. | Xiaowei Cai Xiange Wei Jiao Wu Jiamin Ding Changming Du | 2020 | Waste Disposal and Sustainable Energy2020，2，3： | 1 |
| 10 | Decolofization of acid orange 7 solution by gas-liquid gliding arc discharge plasma 显示文摘 | DU Changming SHI Taihong SUN Yuwei | 2008 | Journal of Hazardous Materials2008，154，： | 1 |
| 11 | Degradation of phenol in aqueous solutions by gas-liquid gliding arc discharges 显示文摘 | Yan Jianhua Du Changming Li Xiaodong | 2006 | Plasma Chemistry and Plasma Processing2006，26，1： | 1 |
| 12 | Decolorization of acid orange 7 solution by gas-liquid gliding arc discharge plasma 显示文摘 | Du Changming Shi Taihong Sun Yuwei | 2007 | Journal of Hazardous Materials2007，，13： | 1 |
| 13 | Electrical and spectral characteristics of a hybrid gliding arc discharge in air-water显示文摘 | DU Changming YAN Jianhua | | 0，，06： | 1 |
| 14 | Decomposition of toluene in a gliding arc discharge plasma reactor显示文摘 | DU Changming YAN Jianhua Bruno C | | 0，，04： | 1 |
| 15 | The application of a non-thermal plasma generated by gas - liquid gliding arc dis- charge in sterilization显示文摘 | Du Changming Wang Jing Zhang Lu | 2012 | New Journal of Physics2012，14，01： | 1 |
| 16 | The polarization-dependent supercontinuum generation in photonic crystal fibers with high birefringence and two-zero dispersion显示文摘A polarization-dependent supercontinuum spectrum source of light from the UV to infrared region has been generated in our photonic crystal fiber with birefringence B=2.23×10 3.By tuning the polarization direction of the input pulse,it is found that the width of the supercontinuum spectrum changes dramatically with the input polarization directions.At the same time,we qualitatively explain the blue-shift peak and the red-shift peak in the experimental spectrum using phase matching conditions on dispersive waves,stoke waves and the pump wave.In addition,we also found that supercontinuum spectrum generation,to some extent,is dependent on the pump wavelength and average power of the pump.The spectrum is broadened with the increase of average power,but unchanged after average power reaches a certain value;when the pump wavelength is located in the anomalous dispersion and further away from the zero-dispersion wavelength,the spectrum of the supercontinuum is wider. | WANG XiaoYan LI ShuGuang HAN Ying DU Ying XIA ChangMing HOU LanTian | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 1 |
| 17 | Plasma chemical degradation of phenol in solution by gas-liquid gliding arc discharge 显示文摘 | Yan Jianhua Du Changming Li Xiaodong | 2005 | Plasma Sources Sci and Technol2005，14，： | 1 |
| 18 | Removal of hexavalent chromium from aqueous solutions by D301, D314 and D354 anion-exchange resins显示文摘 | Taihong Shi Zhuochao Wang Yang Liu Shiguo Jia Du Changming | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 19 | Green hydrogen from bio-ethanol reforming using micro plasma显示文摘Hydrogen is a kind of energy source with a characteristic of high calorific value and plasma is regarded as a good method of hydrogen production.Hydrogen produced from ethanol reforming using micro plasma can be utilized for portable applications.The study introduces water/carbon ratio,residence time,and ethanol mass flow rate as the parameters of experimental conditions,and makes ethanol conversion,gas production rate,gas product selectivity,energy consumption,and efficiency of hydrogen production per unit as the evaluation parameters of ethanol reforming reaction.The experimental results showed that(1)in the argon micro plasma:the maximum ethanol conversion of 25.3%was obtained at residence time=2.1 ms,ethanol mass flow rate=0.01 g/s and S/C=1.0,and the peak value of hydrogen production of 18.7μmol/s was achieved at residence time=2.1 ms,ethanol mass flow rate=0.05 g/s and S/C=1.0;(2)in the air micro plasma:the maximum ethanol conversion of 37.4%was obtained at residence time=2.1 ms,ethanol mass flow rate=0.01 g/s and S/C=1.0,and the peak value of hydrogen production of 36.8μmol/s was achieved at residence time=2.1 ms,ethanol mass flow rate=0.03 g/s and S/C=3.0.These experimental results showed that the microreactor can substantially reduce the volume of the device while producing a large amount of output. | ZiKe Qiu XianGe Wei JianMin Mo JiaMin Ding ChangMing Du | 2020 | Waste Disposal and Sustainable Energy2020，2，4： | 1 |
| 20 | Characteristics of compound 48/80-induced voltage-dependent currents in mouse mast cell tumor P815 cells显示文摘After activation of a mast cell,various ion channel changes on the membrane serve as an important basis for maintaining physiological functions[1,2].Compound 48/80 is usually used as a non-IgE-dependent degranulation agonist[3]that can also induce an increase of intracellular calcium ion concentration and promote the opening of ion channels[4,5].However,it is not clear whether the changes of ion channels induced by compound 48/80 in P815 cells and the changes depend on the recruitment of endogenous calcium ions. | Fan Ye Yucui Jiang Ying Du Ye Tang Chan Zhu Yan Yang Changming Wang Yuan Zhou Guang Yu Xiaolin Yuan Zongxiang Tang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 0 |
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