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| 1 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 2 | Epidermal growth factor receptor inhibits colitis-associated cancer in mice显示文摘 | Dubé Philip E Yan Fang Punit Shivesh Girish Nandini McElroy Steven J Washington M Kay Polk D Brent | 2012 | EN2012，，8： | 2 |
| 3 | Mechanical properties and rapid consolidation of binderless nanostruetured tantalum carbide显示文摘 | Kim B R Woo K D DUb J M | 2009 | Ceram Int2009，35，： | 1 |
| 4 | Quanti- fication and minimization of uncertainty by geostatistical simulations during the characterization of contaminated sites: 3-D approach to a multi-element contamination 显示文摘 | BOUDREAULT J P DUB]~ J S MARCOTFE D 2016 | 2016 | Geoderma2016，264，： | 1 |
| 5 | Solidification microstructure of ZA102,ZA104 and ZA106 magnesium alloys and its effect on creep deformation 显示文摘 | ZHANG Z TREMBLAY R DUBé D COUTURE A | 2000 | Canadian Metallurgical Quarterly2000，39，4： | 1 |
| 6 | Glutathione deficiency is associated with impaired survival in HIV disease显示文摘 | HERZENBERG I A DEROSA S C DUBS J D | 1997 | Proc Natl Acad Sci1997，94，： | 1 |
| 7 | 显示文摘 | Dubé D Royer S Do T On | 2005 | Micropor Mesopor Mater2005，79，： | 1 |
| 8 | Biodiesel production from waste cooking oil:Process design and technological assessment显示文摘 | Zhang Y Dubé M A McLean D D etal | 2003 | Bioresource Technology2003，89，1： | 1 |
| 9 | Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and itsligands显示文摘 | MORAITIS D DUB DE LORENZO M S | 2005 | CancerRes2005，65，2： | 1 |
| 10 | Lactonase and lactonizing activities of human serum paraoxonase (PON1) and rabbit serum PON3显示文摘 | DRAGANOV D I LA DUB N | 2003 | Biochem Pharmacol2003，66，6： | 1 |
| 11 | Laser melting of plasma-sprayed copperceramic coatings for improved erosion resistance显示文摘 | Dallaire S Dubé D Fiset M | 1999 | Wear1999，231，1： | 1 |
| 12 | Intermittent complete vascular exclusion of the liver during hepatectomy:technique and indications显示文摘 | ELIAS D DUB(E) P BONVALOT S | 1998 | Hepatogastroenterology1998，45，20： | 1 |
| 13 | Improvements in the metallography of as-cast AZ91 alloy 显示文摘 | MALTAIS A DUB D FISET M LAROCHE G TURGEON S | 2004 | Materials Characterization2004，52，2： | 1 |
| 14 | Biodiesel produc- tion from waste cooking oil: Economic assessment and sensitivity analysis显示文摘 | Zhang Y Dub M A Mc Lean D D | 2003 | Bioresource Technology2003，90，3： | 1 |
| 15 | Effects of pu-erh tea on oxidative damage and nitric oxide scavenging显示文摘 | Dub P D Yen G C Yen W J | 2004 | J Agric Food Chem2004，52，： | 1 |
| 16 | Microemulsion-based hydrogel formulation of ibuprofen for topical delivery 显示文摘 | CHEN H B CHANG X L DUB D | 2006 | Int J Pharm2006，315，12： | 1 |
| 17 | Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530显示文摘 | Blouin M Brideau C Chan C | 1998 | Bioorg Med Chem Lett1998，，8： | 1 |
| 18 | Competitive Price Discrimination Strategies in a Vertical Channel with Aggregate Data显示文摘 | Besanko D Dub'e J-P Gupta S | 2003 | Management Science2003，49，9： | 1 |
| 19 | An ultrastructural analysis of early fertilization events in the giant scallop, Placopecten magellanicus (Mollusca, k Pelecypoda)显示文摘 | Gicquaud C Dubé F | 1995 | Invert Repod Dev1995，27，： | 1 |
| 20 | Observation of plasmon propagation,redirection,and fan-out in silver nanowires显示文摘 | Sanders A W Routenberg D A Wiley B J Xia Y N Dub resne E R Reed M A | 2006 | Nano Let-ters2006，6，8： | 1 |
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