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| 1 | 奥氮平致代谢紊乱和心血管疾病研究进展显示文摘抗精神病药物是治疗精神分裂症(schizophrenia,SZ)及其他精神病性障碍的最主要手段,目前临床广泛使用的第二代抗精神病药物(second generation antipsychotics,SGA),尤其是奥氮平,能够引起以肥胖和胰岛素抵抗(insulin resistance,IR)为主的代谢紊乱(metabolic disorder),显著增加2型糖尿病和心血管疾病(cardiovascular disease,CVD)的风险[1-3]。研究发现长期使用奥氮平的患者,代谢紊乱和CVD的发生率是普通人群2~3倍[4],因此近年来,奥氮平致代谢紊乱和CVD的机制备受关注。 | 徐劲节 Dake Qi 崔东红 | 2016 | 中国神经精神疾病杂志2016，42，5： | 17 |
| 2 | 抗精神病药物诱导代谢紊乱机制的研究进展☆显示文摘抗精神病药物是治疗精神分裂症的主要临床用药,也用于双相障碍、焦虑障碍等其它精神疾病的治疗。但因其明显的代谢紊乱不良反应而严重影响其依从性及疗效。早在1956年BettieHiles首次报告了第一代抗精神病药氯丙嗪可引起高血糖,但因其突出的锥体外系综合征等神经系统不良反应,使其代谢异常的副作用没有得到充分关注。直到上世纪90年代, | 邢梦娟 Dake Qi 崔东红 | 2011 | 中国神经精神疾病杂志2011，37，8： | 10 |
| 3 | Microbial ingress and in vitro degradation enhanced by glucose on bioabsorbable Mg-Li-Ca alloy显示文摘Biodegradable magnesium alloys are challenging to be implanted in patients with hyperglycemia and diabetes.A hypothesis is suggested that glucose accelerates microbial ingress and in vitro degradation of Mg-Li-Ca implants.Corrosion resistance and mechanical properties was demonstrated using electrochemical,hydrogen evolution and tensile tests.The bacteria from Hank's solution were isolated via 16S rRNA gene analysis.The results revealed that Mg-1Li-1Ca alloy exhibited different responses to Hank's solution with and without glucose.The solution acidity was ascribed to Microbacterium hominis and Enterobacter xiangfangensis,indicating that glucose promoted microbial activity and degradation and deterioration in mechanical property of Mg-1Li-1Ca alloy. | Ling-Yu Li Zhuang-Zhuang Han Rong-Chang Zeng Wei-Chen Qi Xiao-Fan Zhai Yi Yang Yun-Tian Lou Tingyue Gu Dake Xu Ji-Zhou Duan | 2020 | Bioactive Materials2020，5，4： | 2 |
| 4 | 奥氮平诱导的小鼠肥胖模型MCP-1水平分析显示文摘目的探讨脂肪因子和重要的炎症趋化刺激因子——单核细胞趋化蛋白1(MCP-1)的血清水平在奥氮平诱导的肥胖中的作用。方法20只雄性小鼠随机分为两组:实验组和对照组,实验组训练小鼠每天自主摄入奥氮平3mg/kg体重。7周后取小鼠血浆并检测血浆MCP-1水平。解剖小鼠并留取附睾脂肪垫及肾周脂肪,计算小鼠腹腔脂肪指数及肥胖指数。结果实验组体重、附睾脂肪垫及肾周脂肪湿重均高于对照组。经计算,腹腔脂肪指数及肥胖指数均高于对照组,可判断为建模成功。实验组血浆MCP-1水平显著高于对照组。结论在奥氮平诱导的肥胖小鼠模型血浆MCP-1水平升高提示炎症可能参与奥氮平诱导的肥胖。 | 张成芳 邢梦娟 丁文华 Dake Qi 崔东红 | 2013 | 神经疾病与精神卫生2013，，2： | 2 |
| 5 | 影响奥氮平诱导的代谢紊乱动物模型可重复性的因素显示文摘新型抗精神病药物奥氮平引起的代谢紊乱倍受瞩目,但机制未明,建立合适的动物模型是研究其不良反应机制的重要方法,而动物模型的稳定性和可重复性十分关键。文章对近年来奥氮平诱导的代谢紊乱的动物模型研究进行归纳,探讨了影响模型重复性的主要因素,旨在为相关研究提供参考。 | 张成芳 Dake Qi 崔东红 | 2013 | 上海交通大学学报(医学版)2013，33，5： | 1 |
| 6 | Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia显示文摘Background Depressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was found to be altered in both depression and schizophrenia. There are few studies focusing on the prediction of leptin in diagnosis and evaluation of depressive symptoms in schizophrenia.ObjectiveAims To assess the plasma leptin level in patients with schizophrenia and its relationships with depressive symptoms.Methods Cross-sectional studies were applied to(1) compare the levels of plasma leptin between schizophrenia(n=74) and healthy controls(n=50); and(2)investigate the relationship between plasma leptin levels and depressive subscores.Results(1) Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls.(2) Correlation analysis revealed a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale(PANSS).(3) Stepwise multiple regression analyses identified leptin as an influencing factor for depressed factor score on PANSS.Conclusion Leptin may serve as a predictor for the depressive symptoms of chronic schizophrenia. | Jinjie Xu Yumei Jiao Mengjuan Xing Yezhe Lin Yousong Su Wenhua Ding Cuizhen Zhu Yanmin Peng Dake Qi Donghong Cui | 2018 | General Psychiatry2018，31，6： | 1 |
| 7 | MK-801 induces schizophrenic behaviors through downregulating Wnt signaling pathways in male mice显示文摘 | Jianfeng Yu Dake Qi Mengjuan Xing Ruixi Li Kaida Jiang Yuwen Peng Donghong Cui | 2011 | Brain Research2011，，： | 1 |
| 8 | 青春期亚慢性地卓西平暴露对小鼠成年期前脉冲抑制和糖耐量的影响显示文摘目的 探讨青春期亚慢性地卓西平(MK-801)注射对小鼠成年期前脉冲抑制(PPI)和糖耐量的影响。方法 20只青春期小鼠随机分为对照组(n=10)和模型组(n=10),两组小鼠出生后30~43 d分别接受0.9%生理盐水(4 mL/kg)和MK-801(0.6 mg/kg)注射,1次/d,持续2周。每周记录摄食和体质量,并于小鼠成年期(出生后70~80 d之间)进行旷场试验、PPI测试和葡萄糖耐量试验(GTT)。结果 模型组小鼠在79 dB强度的前脉冲刺激时,PPI显著低于对照组(P〈0.05),表明MK-801成功诱导小鼠精神分裂样行为。模型组小鼠体质量也显著低于对照组(P〈0.05)。GTT结果显示:模型组小鼠注射葡萄糖后90 min和120 min的血糖水平显著高于对照组(P〈0.001和P〈0.01),表明MK-801诱导的精神分裂样小鼠模型出现糖耐量异常。两组小鼠的摄食量和旷场试验中的自发活动量差异均无统计学意义(P〉0.05)。结论 青春期亚慢性注射MK-801可诱导小鼠成年期PPI损害和糖耐量异常。 | 丁文华 Dake Qi 鞠培俊 崔东红 | 2014 | 上海交通大学学报(医学版)2014，34，6： | 0 |
| 9 | 奥氮平增加大鼠H9C2心肌细胞巨噬细胞迁移抑制因子基因和蛋白表达显示文摘目的通过奥氮平处理心肌细胞来探讨奥氮平诱导心血管疾病的机制。方法用不同浓度(10,20和40uM)及不同作用时间(1,3,12和24 h)的奥氮平处理大鼠心肌细胞H9C2,检测巨噬细胞迁移抑制因子(Macrophage migration inhibitory factor,MIF)在mRNA及蛋白水平的表达。结果用不同浓度、不同时间的奥氮平处理H9c2细胞时,随着处理浓度的增加及时间的延长,MIF mRNA及MIF蛋白随着浓度的递增及时间的延长而增高(P<0.05)。结论奥氮平处理心肌细胞后,MIF的mRNA及蛋白均发生显著改变,这种改变存在浓度与时间的依赖关系,MIF可能参与奥氮平诱导的心血管系统损伤。 | 邢梦娟 Dake Qi 张成芳 丁文华 江开达 马端 崔东红 | 2012 | 中国神经精神疾病杂志2012，38，3： | 0 |
| 10 | Analysis of wave shoaling and shore-breakers on a low tide terrace beach based on in-situ measurements at Xisha Bay on South China coast显示文摘Low tide terrace beach is a main beach type along South China coasts with strong tidal actions.How strong tides affect wave transformations on low tide terrace beach still remains unclear.In this study,in-situ measurements are conducted on the low terrace beach at Xisha Bay to provide quantitative descriptions of wave shoaling and shore-breaker phenomena under the tidal effects.It is found that wave breaking is unsaturated on the low tide terrace beach at Xisha Bay.Magnitudes of wave skewness and asymmetry increase as wave shoals and achieve the maximum value at the shore-breaker,and then decrease rapidly.Mean energy dissipation rates of shore-breakers are tide-modulated since the bottom slope changes at the shoreward boundary of wave propagation in a tidal cycle.The remaining wave energy flux at the initialization of the shore-breaker is 1%–12%of offshore wave energy flux,and the energy flux ratio decreases with increasing offshore wave heights.Wave attenuation at shore-breakers can be estimated directly from offshore wave conditions based on findings in this study,favoring designs of seawalls or beach nourishment projects.Field datasets on wave transformations can also be used for verifications of wave numerical models. | Yuan Li Chi Zhang Hongshuai Qi Jiacheng Song Weiqi Dai Shanhang Chi Jian Shi Dake Chen | 2023 | Acta Oceanologica Sinica2023，42，7： | 0 |
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