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| 1 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 2 | Aberrant Resting-State Functional Connectivity in the Default Mode Network in Pediatric Bipolar Disorder Patients with and without Psychotic Symptoms显示文摘Mood disorders/psychosis have been associated with dysfunctions in the default mode network(DMN).However,the relative contributions of DMN regions to state and trait disturbances in pediatric bipolar disorder(PBD)remain unclear.The aim of this study was to investigate the possible mechanisms of PBD through brain imaging and explore the influence of psychotic symptoms on functional alterations in PBD patients.Twenty-nine psychotic and 26 non-psychotic PBD patients,as well as 19 age-and sex-matched healthy controls underwent a restingstate functional MRI scan and the data were analyzed by independent component analysis.The DMN component from the fMRI data was extracted for each participant.Spearman's rank correlation analysis was performed between aberrant connectivity and clinical measurements.The results demonstrated that psychotic PBD was characterized by aberrant DMN connectivity in the anterior cingulate cortex/medial prefrontal cortex,bilateral caudate nucleus,bilateral angular gyri,and left middle temporal gyrus,while non-psychotic PBD was not,suggesting further impairment with the development of psychosis.In summary,we demonstrated unique impairment in DMN functional connectivity in the psychotic PBD group.These specific neuroanatomical abnormalities may shed light on the underlying pathophysiology and presentation of PBD. | Yuan Zhong Chun Wang Weijia Gao Qian Xiao Dali Lu Qing Jiao Linyan Su Guangming Lu | 2019 | Neuroscience Bulletin2019，35，4： | 5 |
| 3 | Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene显示文摘The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases(TALENs) technology to generate Leptin receptor(Lepr) knockout rats on the Sprague Dawley(SD) genetic background. Through direct injection of in vitro transcribed m RNA of TALEN pairs into SD rat zygotes, somatic mutations were induced in two of three resulting pups. One of the founders carrying bi-allelic mutation exhibited early onset of obesity and infertility. The other founder carried a chimeric mutation which was efficiently transmitted to the progenies. Through phenotyping of the resulting three lines of rats bearing distinct mutations in the Lepr locus, we found that the strains with a frame-shifted or premature stop codon mutation led to obesity and metabolic disorders. However, no obvious defect was observed in a strain with an in-frame 57 bp deletion in the extracellular domain of Lepr. This suggests the deleted amino acids do not significantly affect Lepr structure and function. This is the first report of generating the Lepr mutant obese rat model in SD strain through a reverse genetic approach. This suggests that TALEN is an efficient and powerful gene editing technology for the generation of disease models. | Yuting Chen Wenqing Lu Na Gao Yi Long Yanjiao Shao Meizhen Liu Huaqing Chen Shixin Ye Xueyun Ma Mingyao Liu Dali Li | 2017 | Science China(Life Sciences)2017，60，2： | 4 |
| 4 | Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics显示文摘 | Xingyu Lu Dali Han Boxuan Simen Zhao Chun-Xiao Song Li-Sheng Zhang Louis C Dore Chuan He | 2015 | Cell Research2015，25，3： | 4 |
| 5 | Genome-wide association study and transcriptome analysis reveal new QTL and candidate genes for nitrogen-deficiency tolerance in rice显示文摘The development of rice cultivars with improved nitrogen use efficiency(NUE)is desirable for sustainable agriculture.Achieving this goal depends in part on understanding how rice responds to low soil nitrogen(N)and identifying causative genes underlying this trait.To identify quantitative trait loci(QTL)or genes associated with low N response,we conducted a genome-wide association study(GWAS)using a diverse panel of 230 rice accessions and performed a transcriptomic investigation of rice accessions with differential responses to low N stress at two N levels.We detected 411 GWAS-associated genes in 5 QTL and 2722 differentially expressed genes in response to low N,of which 24 were identified by both methods and ranked according to gene annotations,literature queries,gene expression,and genetic diversity analysis.The large-scale datasets obtained from this study reveal low N-responsive characteristics and provide insights towards understanding the regulatory mechanisms of N-deficiency tolerance in rice,and the candidate genes or QTL would be valuable resources for increasing rice NUE via molecular biotechnology. | Qing Li Xueli Lu Changjian Wang Lan Shen Liping Dai Jinli He Long Yang Peiyuan Li Yifeng Hong Qiang Zhang Guojun Dong Jiang Hu Guangheng Zhang Deyong Ren Zhenyu Gao Longbiao Guo Qian Qian Li Zhu Dali Zeng | 2022 | The Crop Journal2022，10，4： | 3 |
| 6 | Mn,N co-doped Co nanoparticles/porous carbon as air cathode for highly efficient rechargeable Zn-air batteries Hide Author's Information显示文摘Oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are generally catalyzed by precious metals(Pt)and metal oxides(IrO_(2))which still have many shortages including expensive price,poor selectivity and undesirable stability.In this work,we report a Mn0-doped CoN_(x) on N-doped porous carbon(Mn-CoN_(x)/N-PC)composite from carbonizing metal-organic framework(MOF)derivative as the dual-functional catalyst to boost both the ORR and OER performances.Owing to the strong coordination effect between nitrogen and metal elements,the introduction of N can obviously improve the content of Co-N-C active sites for ORR.Meanwhile,the Mn-doping significantly regulates the electronic structure of the Co element and increases the content of Co^(0) which provide efficient OER active sites.Mn-CoN_(x)/N-PC catalyst delivers super dual-functional activity with a half-wave potential of 0.85 V,better than the 20%Pt/C catalyst(0.82 V).When used in Zn-air batteries for testing,Mn-CoN_(x)/N-PC electrocatalyst shows a high power density(145 mW·cm^(−2))and good cycle performance. | Hanzhen Zheng Fei Ma Hongcen Yang Xiaogang Wu Rui Wang Dali Jia Zhixia Wang Niandi Lu Fen Ran Shanglong Peng | 2022 | Nano Research2022，15，3： | 2 |
| 7 | Two rice cytosolic ascorbate peroxidases differentially improve salt tolerance in transgenic Arabidopsis显示文摘 | Zhenqiang Lu Dali Liu Shenkui Liu | 2007 | Plant Cell Reports2007，，10： | 1 |
| 8 | Geochronology,geochemistry and Hf isotope of monzogranite in Niubiziliang of Qinghai显示文摘Zircon U-Pb dating, whole-rock geochemical analyses and Hf isotope are undertaken for the monzogranite in Niubiziliang area with the aim of constraining its formation time,petrogenesis and the regional tectonic setting. The zircons from monzogranite are euhedral-subhedral in shape,and display rhythm growth zoning,indicating a magmatic origin. LA-ICP-MS zircon U-Pb dating indicates the monzogranite formed most probably in the Late Devonian( 359. 0 ± 2. 6 Ma). The monzogranite has Si O2= 74. 69%--76. 11%,Al2O3=12. 07%--12. 81%,Na2 O + K2 O = 8. 24%--8. 70%,Na2 O / K2 O = 0. 60--0. 68,A / CNK > 1,which shows that it belongs to high-Si and high-K weakly peraluminous calc-alkaline series. The monzogranite is enriched in K,Rb,Th( LILEs) and La,Ce,Sm,Nd( LREEs); and depleted in Ba,U( HREEs) and Ta,Nb( HFSEs).Their zircon εHf( t) values range from 1. 21 to 3. 46,in response to their two-stage Hf model ages( TDM2) ranging from 1 034 Ma to 1 159 Ma,respectively,indicating that the primary magma was derived from the young crust in Meso-Neoproterozoic. Combined with the regional geological evolution background,it is considered that the Niubiziliang monzogranite formed the closure of North Qaidam ocean,which was the stretching stage product after the collision between Qaidam block and Qilian block. | JIANG Hefang SUN Fengyue LI Liang LI Ruihua YU Lu WANG Fei SHEN Dali | 2016 | Global Geology2016，19，3： | 1 |
| 9 | Thermoplastic ternary hybrids of polyurethane,hindered phenol and hindered amine with selective two-phase dispersion显示文摘 | Zhao Xiuying Lu Yonglai Xiao Dali | | 0，，05： | 1 |
| 10 | The relationship between physicochemical characterization and the potential toxicity of fine particulates (PM 2.5 ) in Shanghai atmosphere显示文摘 | Lu Senlin Yao Zhenkun Chen Xiaohui Wu Minghong Sheng Guoying Fu Jiamo Daly Paul | 2008 | Atmospheric Environment2008，，31： | 1 |
| 11 | Zircon U-Pb geochronology and geochemistry of syenogranitesin western Niubiziliang,northwestern Qaidam,Qinghai显示文摘The study presents the results of U-Pb dating of zircons and whole-rock geochemical analyses of a syenogranite located in the western Niubiziliang area,China with the aim of determining its formation time,petrogenesis and the regional tectonic setting. Zircons within the syenogranite are euhedral-subhedral and display rhythmic growth zoning,indicating a magmatic origin. Zircon U-Pb data obtained by LA-ICP-MS indicate the syenogranite formed in the Late Permian (260.7±1.5 Ma). The w(SiO_2) of syenogranites is 70.82%--73.59%,w(Al_2O_3) is 13.49%--14.82%,and w(Na_2O + K_2O) is 7.85%--8.52%,and yield K_2O/Na_2O ratios of 1.06--1.26. Therefore,the syenogranites belong to the high-K calc-alkaline and metaluminous (A/CNK< 1,A/NK > 1) series which display I-type granites similarly. The syenogranites also show the geochemical characteristics of volcanic arc rocks,being enriched in large-ion lithophile elements (LILEs; K,Rb) and light rare-earth elements (LREEs; La,Ce,Sm,Nd),but depleted in high field strength elements( HFSEs; Ta,Nb,P,Ti). On the whole,trace element ratios are close to the mean of the Earth's crust,indicating a lowercrust magma source. The low Sr (161--214) ×10^(-6) and Yb (1.08--1.80)×10^(-6) concentrations indicate that plagioclase and hornblende are residual mineral phases in the source. The regional geology and whole-rock geochemistry suggest that the formation of the syenogranites was related to subduction of the Zongwulong Ocean crust,and the north margin of Qaidam Block during the Late Permian was in an active continental margin tectonic setting. | YU Lu SUN Fengyue LI Bile LI Liang LI Ruihua JIANG Hefang WANG Fei SHAO Ji SHEN Dali | 2017 | Global Geology2017，20，2： | 1 |
| 12 | Heritable expansion of the genetic code in mouse and zebrafish显示文摘 | Yuting Chen Ji Ma Wenqing Lu Meilin Tian Marion Thauvin Chonggang Yuan Michel Volovitch Qian Wang Jeff Holst Mingyao Liu Sophie Vriz Shixin Ye Lei Wang Dali Li | 2017 | Cell Research2017，27，2： | 1 |
| 13 | Metal-organic frameworks-derived hierarchical ZnO structures as efficient sensing materials for formaldehyde detection显示文摘Semiconducting metal oxides have been considered as effective approach for designing highperformance chemical sensing materials.In this paper,a kind of metal-organic frameworks ZIF-8 was used as sacrificed template to prepare porous ZnO hollow nanocubes for the application in gas sensing.It is found that changing calcination temperature and solvent can greatly influence the morphology of the material,which finally affects the gas sensing performance.Acetylene-sensing properties of the sensors were investigated in detail.It can be clearly seen that the material used methanol as reaction solvent with the decomposition at 350℃for 2 h(ZnO-350-M)showed the optimal formaldehyde-sensing behaviors compared with other materials prepared in this experiment.The dynamic transients of the ZnO-350-M-based sensors demonstrated a high response value(about 10),fast response and recovery rate(4 s and 4 s,respectively)and good selectivity towards 100 ppm(part per million)formaldehyde as well as a low detectable limit(1 ppm).As exemplified for the sensing inve stigation towards formaldehyde,the porous ZnO hollow nanocubes showed a significantly improved chemical sensitivity due to the highly syne rgistic effects from the well exposed surfaces,defect states and the robust ZnO. | Nan Zhang Luming Yan Yang Lu Yizhuo Fan Sijia Guo Samira Adimi Dali Liu Shengping Ruan | 2020 | Chinese Chemical Letters2020，31，8： | 1 |
| 14 | Forage Species Suitability Mapping for China Using Topographic, Climatic and Soils Spatial Data and Quantitative Plant Tolerances显示文摘Selecting plants adapted to the climatic and soil conditions of specific locations is essential for environmental protection and economic sustainability of agricultural and pastoral systems. This is particularly true for countries like China with a diversity of climates and soils and intended uses. Currently, proper species selection is difficult due to the absence of computer-based selection tools. Climate and soil GIS layers, matched with a matrix of plant characteristics through rules describing species tolerances would greatly improve the selection process. Better matching will reduce environmental hazards and economic risks associated with sub-optimal plant selection and performance. GIS-based climate and soil maps have been developed for China. A matrix of quantitative species tolerances has been developed for example forage species and used in combination with an internet map server that allows customized map creation. A web-based decision support system has been developed to provide current information and links to original data sources, supplementary materials, and selection strategies. | David B Hannaway Christopher Daly CAO Wei-xing LUO Wei-hong WEI Yu-rong ZHANG Wei-li XU Ai-guo LU Chang-ai SHI Xue-zheng LI Xiang-lin | 2005 | Agricultural Sciences in China2005，4，9： | 0 |
| 15 | Two New Diterpenoids from Isodon Lungshengensis显示文摘Two new diterpenoids, lungshengenin B and C (1-2), were isolated from Isodon lungshengensis. The structures were determined as 1α-2β,3β,11β,15β-tetraacetoxy ent-kaur-16-en-6-one, 11α-hydroxy-2β, 3β, 6α-triacetoxy-ent-kaur-16-en-15-one by 1 D and 2D N-MR techniques (COSY, HETCOR, COLOC) | Bei JIANG Xing Rong CHEN Ze Qin LU Zhong Wen LIN and Han Dong SUN(Laboratory of Pbytochemistry, Kunming Institute of Botany, Academia Sinica Kunming 650204)( W of Pharmacy Dali Medical College, Dali, Yunnan 671000)(Department of Chemistry and Chemical I | 1997 | Chinese Chemical Letters1997，8，12： | 0 |
| 16 | A study of particle number fluctuation under BCS theory显示文摘Particle number fluctuations in BCS theory are studied with the relativistic mean-field theory and the shell effects of particle number fluctuations are first discovered. By analyzing the relative errors of the particle number fluctuations, we find that the particle number fluctuations are relevant with the odd-even character. We later apply this method to the examination of the new shell structure, showing that N = 184 for the neutron is indeed a new closed shell. | DING BinGang NING PingZhi ZHANG DaLi LU DingHui | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，2： | 0 |
| 17 | Controls on the Gas Hydrate Occurrence in Lower Slope to Basin-Floor,Northeastern Bay of Bengal显示文摘High resolution seismic data and newly acquired logging data reveal the presence of gas hydrates in the deep-water area in the northeastern Bay of Bengal.Bottom Simulating Reflectors(BSRs)appear at 430 ms beneath the seafloor,with the features of typical gas hydrates reported elsewhere except for some discontinuity.The BSR distribution is closely related to the position of anticline structures and turbidite channels.Anticlines provide conduits for the upward migration of gases from deeper intervals,while the turbidite sands within channels act as reservoirs for gas hydrate accumulation.High sedimentation rates in the Bengal Fan were ge-nerally favorable to produce a great amount of methane gas,providing favorable preconditions for the formation of gas hydrates.The discovery of gases in adjacent area indicates the contribution of the biogenic gas to the formation of gas hydrates.Meanwhile,seismic sections provide the evidence for the potential thermogenic gas kitchen in deep intervals.The anticline structures and the associated vertical fractures may constitute vertical fluid flowing conduits,which hydraulically connect the two deeper thermogenic petroleum systems(i.e.,rifting and Eocene-Oligocene source rocks)with the turbidite reservoirs and thus facilitate the fluid migration from the sources to the reservoirs,generating favorable conditions for gas-hydrate accumulation in such foreland setting. | LU Yintao LUAN Xiwu SHI Boqing FAN Guozhang RAN Weimin XU Ning WANG Haiqiang SHAO Dali DING Liangbo WANG Xingxing | 2022 | Journal of Ocean University of China2022，21，4： | 0 |
| 18 | WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling显示文摘Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor progression.These findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3 pathway as a promising strategy for precise treatment of HNSCC. | Qingling Huang Yi Xiao Ting Lan Youguang Lu Li Huang Dali Zheng | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 19 | Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration显示文摘CRISPR/Cas9-mediated site-specific insertion of exogenous genes holds potential for clinical applications.However,it is still infeasible because homologous recombination(HR)is inefficient,especially for nondividing cells.To overcome the challenge,we report that a homology-independent targeted integration(HITI)strategy is used for permanent integration of high-specificity-activity Factor IX variant(F9 Padua,R338L)at the albumin(Alb)locus in a novel hemophilia B(HB)rat model.The knock-in efficiency reaches 3.66%,as determined by droplet digital PCR(dd PCR).The clotting time is reduced to a normal level four weeks after treatment,and the circulating factor IX(FIX)level is gradually increased up to 52%of the normal level over nine months even after partial hepatectomy,demonstrating the amelioration of hemophilia.Through primer-extension-mediated sequencing(PEM-seq),no significant off-target effect is detected.This study not only provides a novel model for HB but also identifies a promising therapeutic approach for rare inherited diseases. | Xi Chen Xuran Niu Yang Liu Rui Zheng Lei Yang Jian Lu Shuming Yin Yu Wei Jiahao Pan Ahmed Sayed Xueyun Ma Meizhen Liu Fengxiang Jing Mingyao Liu Jiazhi Hu Liren Wang Dali Li | 2022 | Journal of Genetics and Genomics2022，49，12： | 0 |
| 20 | Multi-Scale Pore Structure Heterogeneity in Tuff Reservoirs Investigated with Multi-Experimental Method and Fractal Dimensions in Chang 7 Formation,Southern Ordos Basin显示文摘The tight tuff reservoir is an unusual type of unconventional reservoir with strong heterogeneity.However,there is a lack of research on the microscopic pore structure that causes the heterogeneity of tuff reservoirs.Using the Chang 7 Formation in Ordos Basin,China as a case study,carbon-dioxide gas adsorption,nitrogen gas adsorption and high-pressure mercury injection are integrated to investigate the multi-scale pore structure characteristics of tuff reservoirs.Meanwhile,the fractal dimension is introduced to characterize the complexity of pore structure in tuff reservoirs.By this multi-experimental method,the quantitative characterizations of the full-range pore size distribution of four tuff types were obtained and compared in the size ranges of micropores,mesopores and macropores.Fractal dimension curves derived from full-range pores are divided into six segments as D1,D2,D3,D4,D5 and D6 corresponding to fractal characteristics of micropores,smaller mesopores,larger mesopores,smaller macropores,medium macropores and larger macropores,respectively.The macropore volume,average macropore radius and fractal dimension D5 significantly control petrophysical properties.The larger macropore volume,average macropore radius and D5 correspond to favorable pore structure and good reservoir quality,which provides new indexes for the tuff reservoir evaluation.This study enriches the understanding of the heterogeneity of pore structures and contributes to unconventional oil and gas exploration and development. | Hao Lu Qing Li Dali Yue Dongdong Xia Shenghe Wu Lang Wen Yu He | 2024 | Journal of Earth Science2024，35，2： | 0 |
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