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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 3 | Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination显示文摘DNA 双海滨裂缝(DSB ) 是高度细胞毒素的损害并且如果,形成主要威胁到染色体稳定性不适当地修理了。我们和其它以前证明了导致 DSB 的小 RNA (diRNAs ) 的一个班在 DSB 地点附近从序列被生产。DiRNAs 与 Argonaute 被联系(以前) 蛋白质和戏在 DSB 修理的一个重要角色,不过,他们通过行动的机制仍然保持不清楚。这里,我们报导在 DSB 修理的 diRNAs 的角色被限制由相应再结合(HR ) 修理并且它明确地在哺乳动物的房间依靠受动器蛋白质 Ago2。有趣地,我们证明 Ago2 与 Rad51 形成建筑群并且相互作用在与电离对待的房间被提高放射。我们证明在 DSB 地点和 HR 修理的 Rad51 累积取决于催化活动和 Ago2 的小 RNA 有约束力的能力。相反,象装载的 RPA 和 Mre11 一样的 DSB 切除术由 Ago2 或 Dicer 弄空是未受影响的,建议 Ago2 很多半在调停直接工作在 DSB 的 Rad51 累积。一起拿,我们的调查结果建议由 diRNAs 指导了那, Ago2 能在 DSB 支持 Rad51 招募或保留由 HR 便于修理。 | Min Gao Wei Wei Ming-Ming Li Yong-Sheng Wu Zhaoqing Ba Kang-Xuan Jin Miao-Miao Li You-Qi Liao Samir Adhikari Zechen Chong Ting Zhang Cai-Xia Guo Tie-shah Tang Bing-Tao Zhu Xing-Zhi Xu Niels Mailand Yun-Gui Yang Yijun Qi Jannie M Rendtlew Danielsen | 2014 | Cell Research2014，24，5： | 3 |
| 4 | Portrait of the PI3K/AKT-pathway in colorectal cancer显示文摘 | Stine Aske Danielsen Peter Wold Eide Arild Nesbakken Tormod Guren Edward Leithe Ragnhild A. Lothe | 2014 | BBA - Reviews on Cancer2014，，： | 2 |
| 5 | Ulnar nerve repair by the silicon chamber technique:case report显示文摘 | DAHLIN LB DANIELSEN N | 1991 | Scand J Plast Reconslr Hand Surg1991，25，： | 1 |
| 6 | Transport of insulin across rabbit nasal mucosa in vitro induced by didecanoy-L-α-phosphatidylcholine显示文摘 | Carstem S Danielsen G Guldhammer B | 1993 | Diabetes1993，42，7： | 1 |
| 7 | Molecular characterization of tet (M) genes in Lactobacillus isolates from different types of fermented dry sausage显示文摘 | GEVERS D DANIELSEN M HUYS G | 2003 | Applied and Environmental Microbiology2003，69，2： | 1 |
| 8 | Lactational dietary fat levels and sources influence milk composition and performance of sows and their progeny显示文摘 | Lauridsen C Danielsen V | 2004 | Livest Prod Sci2004，91，1： | 1 |
| 9 | Lactational dietary fat levels and sourc- es intluence milk composition and performance of sows and their progeny显示文摘 | Lam'idsen C Danielsen V | 2004 | Livestoek Produetion Science2004，91，12： | 1 |
| 10 | Cancer associated with obstetric delivery:results of linkage with the California cancer registry显示文摘 | Smith LH Danielsen B Allen ME | 2003 | Am J Obstet Gynecol2003，189，4： | 1 |
| 11 | On the nucleation and dissolution process of Z-phase Cr (V, Nb ) N in martensitic 12% Cr steels显示文摘 | Danielsen H K Hald J | 2009 | Materials Science and Engineering2009，，505： | 1 |
| 12 | School-related social support and students'perceived life satisfaction显示文摘 | Danielsen A.G Samdal O Hetland J Wold B | | 0，，04： | 1 |
| 13 | Streptococ-cus thermophilus core genome: comparative genome hybridizationstudy of 47 strains 显示文摘 | RASMUSSEN T B DANIELSEN M VALINA O | 2008 | Applied and Environmental Microbiology2008，74，15： | 1 |
| 14 | Nerve regeneration in a pseudo-nerve'graft created in a silicone tube 显示文摘 | Zhao Q Lundborg G Danielsen N Bjursten LM Dahlin LB | 1997 | Brain Res1997，769，1： | 1 |
| 15 | Childbearing beyond age 40:pregnancy outcome in 24,032 cases显示文摘 | Gilbert WM Nesbitt TS Danielsen B | 1999 | Obstet Gynecol1999，93，1： | 1 |
| 16 | A thermodynamic model of the Z-phase Cr (V, Nb) N 显示文摘 | Danielsen H K Hald J | 2007 | Calphad2007，31，4： | 1 |
| 17 | Changes in body composition,cardiovascular disease risk factors,and eating behavior after an intensive lifestyle intervention with high volume of physical activity in severely obese subjects: a prospective clinical controlled trial显示文摘 | Danielsen KK Svendsen M Mgehlum S | 2013 | J Obes2013，，32： | 1 |
| 18 | Antenatal and intrapartumrisk factors for seizures in term newborns: a population-based study,California 1998-2002显示文摘 | Glass HC Pham TN Danielsen B | 2009 | J Pediatr2009，154，1： | 1 |
| 19 | Cancer associ- ated with obstetric delivery: results of linkage with the California cancer registry显示文摘 | Smith LH Danielsen B Allen ME | 2003 | Am J Obstet Gynecol2003，189，4： | 1 |
| 20 | Three-dimensional analysis of potential vorticity associated with tropopause folds and observed variations of ozone and carbon monoxide 显示文摘 | Danielsen E F Hipskind R S Gaines S E | 1987 | Journal of Geophysical Research1987，92，： | 1 |
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