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| 1 | Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures显示文摘Vascular endothelial growth factor A(Vegfa) signaling regulates vascular development during embryogenesis and organ formation.However,the signaling mechanisms that govern the formation of various arteries/veins in various tissues are incompletely understood.In this study,we utilized transcription activator-like effector nuclease(TALEN) to generate zebrafish vegfaa mutants.vegfaa^(-/-) embryos are embryonic lethal,and display a complete loss of the dorsal aorta(DA) and expansion of the cardinal vein.Activation of Vegfa signaling expands the arterial cell population at the expense of venous cells during vasculogenesis of the axial vessels in the trunk.Vegfa signaling regulates endothelial cell(EC) proliferation after arterial-venous specification.Vegfa deficiency and overexpression inhibit the formation of tip cell filopodia and interfere with the pathfinding of intersegmental vessels(ISVs).In the head vasculature,vegfaa^(-/-) causes loss of a pair of mesencephalic veins(MsVs) and central arteries(CtAs),both of which usually dvelop via sprouting angiogenesis.Our results indicate that Vegfa signaling induces the formation of the DA at the expense of the cardinal vein during the trunk vasculogenesis,and that Vegfa is required for the angiogenic formation of MsVs and CtAs in the brain.These findings suggest that Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures. | Daqing Jin Diqi Zhu Yabo Fang Yiwei Chen Gaihong Yu Weijun Pan Dong Liu Fen Li Tao P.Zhong | 2017 | Journal of Genetics and Genomics2017，44，10： | 6 |
| 2 | In vitro differentiation of human adipose-derived mesenchymal stem cells into endothelial-like cells显示文摘The neovascularization of ischemic tis- sue is a crucial initial step for the functional rehabili- tation and wound healing. However, the short of seed cell candidate for the foundation of vascular network is still a big issue. Human adipose tissue derived mesenchymal stem cells (hADSCs), which possess multilineage potential, are capable of adipogenic, osteogenic, and chondrogenic differentiation. We examined whether this kind of stem cells could dif- ferentiate into endothelial-like cells and participate in blood vessel formation, and whether they could be used as an ideal cell source for therapeutic angio- genesis in ischemic diseases or vascularization of tissue constructs. The results showed that hADSCs, grown under appropriately induced conditions, dis- played characteristics similar to those of vessel en- dothelium. The differentiated cells expressed endo- thelial cell markers CD34 and vWF, and had high metabolism of acetylated low-density lipoprotein and prostacyclin. In addition, the induced cells were able to form tube-like structures when cultured on matrigel. Our data indicated that induced hADSCs could ex- hibit characteristics of endothelial cells. Therefore, these cells, as a source of human endothelial cells, may find many applications in such realms as engi- neering blood vessels, endothelial cell transplantation for myocardial regeneration, and induction of angio- genesis for treatment of regional ischemia. | GUAN Lidong LI Shaoqing WANG Yunfang YUE Huimin LIU Daqing HE Lijuan BAI Cixian YAN Fang NAN Xue SHI Shuangshuang PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，15： | 6 |
| 3 | Corrosion protection of waterborne epoxy coatings containing mussel-inspired adhesive polymers based on polyaspartamide derivatives on carbon steel显示文摘A novel mussel-inspired adhesive polymer(PHEA-DOPA) containing the 3,4-dihydroxyphenylalanine(DOPA) functional group based on polyaspartamide derivatives was synthesized. The corrosion protection of the waterborne epoxy coatings containing the adhesive polymers was investigated by electrochemical impedance spectroscopy(EIS). The results indicated that the PHEA-DOPA could improve the corrosion resistance of the waterborne epoxy coating. The corrosion products were also analyzed by Raman microspectroscopy(RM), indicating the formation of the insoluble DOPA-Fe complexes on the carbon steel surface. These complexes simultaneously acting as a passivating layer, can inhibit the process of corrosion at the metal-solution interface. The differential scanning calorimeter(DSC) measurement indicated that PHEA-DOPA can increase the crosslinking density of coating. The effect of O_2 on the protective mechanism of the PHEA-DOPA coating in a 3.5% NaCl solution was also evaluated by EIS. The results indicated that the barrier effect was significantly improved under aerated conditions because DOPA was oxidized to DOPA-quinone(Dq) by O_2, which triggered the reaction with Fe ions that were released from the surface of the carbon steel. This led to more compact coatings. | Mingliang Yang Jianhua Wu Daqing Fang Bo Li Yang Yang | 2018 | Journal of Materials Science & Technology2018，34，12： | 4 |
| 4 | Characteristics of remaining oil viscosity in water-and polymer-flooding reservoirs in Daqing Oilfield显示文摘The experimental analysis of 21 crude oil samples shows a good correlation between high molecular-weight hydrocarbon components (C 40+) and viscosity.Forty-four remaining oil samples extracted from oil sands of oilfield development coring wells were analyzed by high-temperature gas chromatography (HTGC),for the relative abundance of C 21-,C 21-C 40 and C 40+ hydrocarbons.The relationship between viscosity of crude oil and C 40+ (%) hydrocarbons abundance is used to expect the viscosity of remaining oil.The mobility characteristics of remaining oil,the properties of remaining oil,and the next displacement methods in reservoirs either water-flooded or polymer-flooded are studied with rock permeability,oil saturation of coring wells,etc.The experimental results show that the hydrocarbons composition,viscosity,and mobility of remaining oil from both polymer-flooding and water-flooding reservoirs are heterogeneous,especially the former.Relative abundance of C 21- and C 21-C 40 hydrocarbons in polymer-flooding reservoirs is lower than that of water-flooding,but with more abundance of C 40+ hydrocarbons.It is then suggested that polymer flooding must have driven more C 40- hydrocarbons out of reservoir,which resulted in relatively enriched C 40+,more viscous oils,and poorer mobility.Remaining oil in water-flooding reservoirs is dominated by moderate viscosity oil with some low viscosity oil,while polymer-flooding mainly contained moderate viscosity oil with some high viscosity oil.In each oilfield and reservoir,displacement methods of remaining oil,viscosity,and concentration by polymer-solution can be adjusted by current viscosity of remaining oil and mobility ratio in a favorable range.A new basis and methods are suggested for the further development and enhanced oil recovery of remaining oil. | XU ZhengShun,ZHANG JuHe,FENG ZiHui,FANG Wei & WANG FengLan Exploration and Development Research Institute,Daqing Oilfield Company Ltd.,Daqing 163712,China | 2010 | Science China Earth Sciences2010，53，1： | 3 |
| 5 | Double-peak ageing behavior of Mg–2Dy–0.5Zn alloy显示文摘 | Guangli Bi Daqing Fang Lei Zhao Qingxin Zhang Jianshe Lian Qing Jiang Zhonghao Jiang | 2011 | Journal of Alloys and Compounds2011，，32： | 2 |
| 6 | A New Family of Ce6MoO15 as Fast Oxide Ion Conductor显示文摘A novel solid solution Ce6MoO15 was achieved. Their structure and oxide ionic conductivity were studied.Based on Ce6MoO15, rare earth element substitution on cerium site shows that all resulting oxides enhance the conductivity further, and have high oxide-ion conductivity, which may be a kind of promising material for SOFCs. | Feng Jing Bo Qibing Che Ping Wang Jingping Liu Jianfen Lu Minfeng Zhang Deping Fang Daqing Cao Xueqiang Meng Jian | 2004 | Journal of Rare Earths2004，22，z2： | 2 |
| 7 | Mechanical properties and deformation mechanisms of a novel fine-grained Mg-Gd-Y-Ag-Zr-Ce alloy with high strength-ductility synergy显示文摘Grain boundary precipitation and segregation play an important role in determining mechanical properties of Mg alloys. In the present work, we studied work focuses on the strengthening and deformation mechanism of coarse-grained(CG) and fine-grained(FG) Mg-Gd-Y-Ag-Zr-Ce alloy. The CG alloy is strengthened by means of age-strengthening with the formation of both basal plate γ' and prismatic plate β’ precipitates in the grain interior. While the strengthening of FC alloy is completed by intergranular alloying segregation and intragranular precipitates γ' and β’. The segregation of alloying elements at the grain boundary and formation of sub-micron particles can stabilize the grain boundary and suppress the intergranular deformation. Consequently, dislocations could be trapped near γ' and β’ precipitates in the grain interior. Unlike CG alloys, the FG alloys exhibit a heterogeneous transition from elastic to plastic deformation via the Lüders plateau. The rapid gliding dislocation multiplications and fine-grained size are necessary and sufficient conditions for the Lüders strains. Our work provides the insights on the evolution of fine-grained microstructure and helps for the design of Mg alloys with good mechanical properties. | Xiaofei Cui Wei Fu Daqing Fang Guangli Bi Zijun Ren Shengwu Guo Suzhi Li Xiangdong Ding Jun Sun | 2021 | Journal of Materials Science & Technology2021，，7： | 1 |
| 8 | High ductility of a bi-modal Mg-7wt.%Y alloy at low temperature prepared by high pressure boriding and semi-solid extrusion显示文摘 | Hui Fu Hui Li Daqing Fang Xuecheng Cai Qiuming Peng | 2016 | Materials & Design2016，，： | 1 |
| 9 | Heterogeneous fiberous structured Mg-Zn-Zr alloy with superior strength-ductility synergy显示文摘Here we reported a heterogeneous fiberous structured Mg-5.6Zn-0.6Zr(wt%)alloy obtained by conventional extrusion method,which exhibited high yield strength of∼345 MPa,ultimate tensile strength of∼370 MPa,and high tensile strain of∼20.5%,superior to most of the Mg-Zn based alloys reported so far.The extraordinarily high mechanical properties were mainly attributed to the heterogeneous fiberous structure consisting of alternating coarse-and fine-grain layers.Grains in the different layers grew into the neighboring layers,ensuring a good layer bonding.A high Schmid factor and geometric compatibility factor for pyramidal slip led to full slip transfer between the neighboring coarse grains and fine grains,which could help to release the stress concentration and avoid early fracture.The profuse acti-vatedglide dislocations could render the unprecedented high tensile strain.The constraint by the hard fine-grain domains made the soft coarse-grain domains strong like the hard fine-grain domains,as well as the nanoscale precipitates pinning dislocations,contributed to the high strength.The hetero-geneous microstructure design was shown to have synergistic improvement in strength-ductility balance,which could be an inspiring strategy to improve mechanical properties of hexagonal close-packed(hcp)metals. | Wei Fu Pengfei Dang Shengwu Guo Zijun Ren Daqing Fang Xiangdong Ding Jun Sun | 2023 | Journal of Materials Science & Technology2023，，3： | 1 |
| 10 | Microstructures and mechanical properties of Mg–8Gd–0.6Zr–xNd (x?=?0, 1, 2 and 3 mass%) alloys显示文摘 | Qiuming Peng Yaoming Wu Daqing Fang Jian Meng Limin Wang | 2007 | Journal of Materials Science2007，，11： | 1 |
| 11 | Microstructure, tensile properties, and creep behavior of high-pressure die-cast Mg–4Al–4RE–0.4Mn (RE?=?La, Ce) alloys显示文摘 | Jinghuai Zhang Ke Liu Daqing Fang Xin Qiu Dingxiang Tang Jian Meng | 2009 | Journal of Materials Science2009，，8： | 1 |
| 12 | High strength-ductility and rapid degradation rate of as-cast Mg-Cu-Al alloys for application in fracturing balls显示文摘Specially designed Mg-Cu-Al alloys were prepared for the application in fracturing balls.In comparison to Mg-2.5 Cu alloy,Mg-2.5 Cu-6.0 Al alloy exhibits an improved compressive strength of 378 MPa and compressive strain of 27%,combined with a high degradation rate of 383 mm/y.Two kinds of second-phases are found in Mg-Cu-Al alloys,i.e.MgAlCu andβ-Mg_(17)Al_(12)+Al_(2)Cu phases.They form a discontinuous network and act as cathodes for micro-galvanic corrosion,leading to a high degradation rate.Moreover,the addition of Al could improve the strength and ductility simultaneously in Mg-Cu alloys.The enhancement of strength primarily arises from the solid-solution strengthening and second-phase hardening.A high density of basal,non-basal dislocations and stacking faults were activated upon mechanical deformation.This accounts for the good ductility in Mg-Cu-Al alloys. | Wei Tan Tianshu Li Suzhi Li Daqing Fang Xiangdong Ding Jun Sun | 2021 | Journal of Materials Science & Technology2021，，35： | 1 |
| 13 | Microstructures and mechanical properties of Mg–8Gd–0.6Zr–xNd (x?=?0, 1, 2 and 3 mass%) alloys显示文摘 | Qiuming Peng Yaoming Wu Daqing Fang Jian Meng Limin Wang | 2007 | Journal of Materials Science2007，，11： | 1 |
| 14 | An elevated temperature Mg–Dy–Zn alloy with long period stacking ordered phase by extrusion显示文摘 | Guangli Bi Daqing Fang Lei Zhao Jianshe Lian Qing Jiang Zhonghao Jiang | 2011 | Materials Science & Engineering A2011，，10： | 1 |
| 15 | Hydrothermal synthesis and crystal structure of a new two-dimensional zinc cit- ratecomplex 显示文摘 | PING CHE DAQING FANG DEPING ZHANG JING FENG JINGPING WANG NINGHAI HU and JIAN MENG | 2005 | Joumal of Coordinatian Chemistry2005，，： | 1 |
| 16 | Microstructures and mechanical properties of Mg–8Gd–0.6Zr–xNd (x?=?0, 1, 2 and 3 mass%) alloys显示文摘 | Qiuming Peng Yaoming Wu Daqing Fang Jian Meng Limin Wang | 2007 | Journal of Materials Science2007，，11： | 1 |
| 17 | Analysis of Hot Rolling Routes of AZ31B Magnesium Alloy and Prediction of Tensile Property of Hot-rolled Sheets显示文摘At the initial rolling temperature of 250 to 400 ℃, AZ31B magnesium alloy sheets were hot rolled by four different rolling routes. Microstructures and mechanical properties of the hot-rolled magnesium alloy sheets were analyzed by optical microscope and tensile tests respectively. Based on the Hall-Petch relation, considering the average grain size and grain size distribution, the nonlinear fitting analysis between the tensile strength and average grain size was carried on, and then the prediction model of tensile strength of hot-rolled AZ31B magnesium alloy sheet was established. The results indicate that, by rolling with multi-pass cross rolling, uniform, fine and equiaxial grain microstructures can be produced, the anisotropy of hot-rolled magnesium sheet can also be effectively weakened. Strong correlation was observed between the average grain size and tensile property of the hot-rolled magnesium alloy sheet. Grain size distribution coefficient d_(CV) was introduced to reflect the dispersion degree about a set of grain size data, and then the Hall-Petch relation was perfected. Ultimately, the prediction accuracy of tensile strength of multi-pass hot-rolled AZ31B magnesium alloy was improved, and the prediction of tensile property can be performed by the model. | 范沁红 徐海洁 MA Lifeng JIA Weitao HUANG Zhiquan LIU Guangming LIN Jinbao FANG Daqing | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，2： | 1 |
| 18 | Enhancing corrosion resistance of ZK60 magnesium alloys via Ca microalloying: The impact of nanoscale precipitates显示文摘Enhancing corrosion resistance of Mg-Zn alloys with high strength and low cost was critical for broadening their large-scale practical applications. Here we prepared solutionized, peak-and over-aged ZK60 alloys with and without microalloying Ca(0.26 wt.%) to explore the effects of nanoscale precipitates on their corrosion behavior in detail via experimental analyses and theoretical calculations. The results suggested the peak-aged ZK60 alloy with Ca addition showed improved corrosion resistance in comparison with the alloys without Ca,owing to the contribution of Ca on the refinement of precipitates and increase in their number density. Although the precipitates and Mg matrix formed micro-galvanic couples leading to dissolution, the fine and dense precipitates could generate “in-situ pinning” effect on the corrosion products, forming a spider-web-like structure and improving the corrosion inhibition ability accordingly. The pinning effect was closely related to the size and number density of precipitates. This study provided important insight into the design and development of advanced corrosion resistant Mg alloys. | Wei Fu Hejie Yang Tianshu Li Jiapeng Sun Shengwu Guo Daqing Fang Weichao Qin Xiangdong Ding Yimin Gao Jun Sun | 2023 | Journal of Magnesium and Alloys2023，11，9： | 0 |
| 19 | Floristic Study of Vascular Plants in Typical Plant Communities in the Middle and Upper Reaches of the Yarlung Zangbo River显示文摘[Objective] Species composition and flora of vascular plants in the middle and upper reaches of the Yarlung Zangbo River were analyzed,to provide scientific basis for the estimation and protection of plant diversity,construction of ecological security shelter for the Tibetan Plateau.[Methods] In the middle and upper reaches of the Yarlung Zangbo River,quadrat (line transect) method was applied to investigate the phytocoenoses in sample plots,and relative literature was used to analyze the floristic composition and floristic element of vascular plants in the middle and upper reaches of the Yarlung Zangbo River.[Results]① There are 96 species (including subspecies and variations),69 genera of 35 vascular plant families,accounting for 16.83%,5.48%,1.66% and 11.63%,2.02%,0.31% of total vascular plant families,genera and species in Tibet and China.② There are 24 monotypic-genus families,accounting for 68.57% of the total family number in the local area;22 monotypic-species families,accounting for 62.86% of the total family number in the local area.Local flora shows the characteristics of ancient relict,such as Euphorbiaceae,Rubiaceae,Liliaceae and Ranunculaceae,they are all ancient primitive groups of the third flora and the fourth flora.③ Local vascular plant genera fall into 10 areal types and 8 variations.④ Temperate elements are much more than tropical elements,R/T is 0.19,indicating that vascular plants have typical temperate nature and residual tropical nature.There are only a few endemic genera,but more endemic species to the local area,and these species are closely related,of which there are some transitional species,indicating that local flora is too young to experience more differentiation and specialization.⑤ There are 24 Chinese endemic species,accounting for 25% of total number of species in the local area;among which there are 12 endemic species to Tibet,accounting for 50% of endemic species to China,12.5% of total number of species in the local area.Four key wild plant species are included in the second batch of national key protection.[Conclusions]① There are scarce plant groups in the local area.② Among the obvious advantages,single-genus (species) families possess the absolute advantage,and the flora has ancient origins.③ The local flora has diversified distribution types,and the complicated geographical elements.④ Temperate species possess obvious advantages,and the flora is young.⑤ Rich unique and rare species have high species diversity protection and research value. | GE Qingsong QU Xingle LUO Daqing ZHENG Weilie FANG Jiangping | 2019 | Journal of Landscape Research2019，11，5： | 0 |
| 20 | Corrosion mechanism of Mg alloys involving elongated long-period stacking ordered phase and intragranular lamellar structure显示文摘It is a long-term challenge to further improve the corrosion resistance while ensuring the strength of magnesium(Mg)alloys.Revealing the effect of potential fluctuation on the micro-galvanic corrosion and the subsequent film formation is important for understanding the corrosion mechanism of Mg alloys with multiple strengthening phases/structures.Here,we prepared the high-strength Mg-14.4Er-1.44Zn-0.3Zr(wt.%)alloys containing hybrid structures,i.e.,elongated long-period stacking ordered(LPSO)blocks+intragranular stacking faults(SFs)/LPSO lamellae.The Mg alloy with elongated LPSO blocks and intragranular LPSO lamellae(EZ-500 alloy)obtains good corrosion resistance(2.2 mm y^(–1)),while the Mg alloy containing elongated LPSO blocks and intragranular SFs(EZ-400 alloy)shows a significantly higher corrosion rate(6.9 mm y^(–1)).The results of scanning Kelvin probe force microscopy(SKPFM)show the elongated LPSO blocks act as cathode phase(87 mV in EZ-400 alloy),and the SFs serve as the weak anode(30 mV in EZ-400 alloy),resulting in high potential fluctuation in EZ-400 alloy.On the contrary,both elongated blocks and intragranular lamellae are cathodic LPSO phase(67–69 mV)in EZ-500 alloy,leading to a lower potential fluctuation.Quasi in-situ atomic force microscope(AFM)observation indicates that high potential fluctuation would cause strong micro-galvanic corrosion,and subsequently leads to the failure in rapid formation of corrosion film,finally forming a loose and porous film,while relatively low potential fluctuation could result in more uniform corrosion mode and facilitate the rapid formation of protective film.Therefore,we propose that it is an effective way to develop high-strength corrosionresistant Mg alloys by controlling the potential fluctuation to form a“uniform potential”strengthening microstructure。 | Jinshu Xie Jinghuai Zhang Zhi Zhang Zijian Yu Zhihao Xu Ru Wang Daqing Fang Xiaobo Zhang Xiaoru Zhang Ruizhi Wu | 2023 | Journal of Materials Science & Technology2023，，20： | 0 |
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