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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 3 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 4 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 5 | Effects of a mutual support group for families of Chinese people with schizophrenia:18-month follow-up显示文摘 | Wai-Tong Chien Sally W C Chan David R Thompson | 2006 | The British journal of psychiatry:the journal of mental science2006，189，： | 1 |
| 6 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 7 | Evaluation and pzesentation of dam failure and flood risks显示文摘 | Thompson Kay D Stedinger Jery R Heath David C | 1991 | Journal of Water Resources Planning and Management1991，，1： | 1 |
| 8 | Comparison of methods for parameter selection in techno regularization with application to inverse force determination显示文摘 | YOUNG G C TITHE N THOMPSON DAVID J | 2007 | Journal of Sound and Vibration2007，304，： | 1 |
| 9 | Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care显示文摘 | Martin R Cowie Allan D Struthers David A Wood Andrew JS Coats Simon G Thompson Philip A Poole-Wilson George C Sutton | 1997 | The Lancet . 1997 (9088)1997，，9088： | 1 |
| 10 | Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial显示文摘 | Phil Quirke Robert Steele John Monson Robert Grieve Subhash Khanna Jean Couture Chris O’Callaghan Arthur Sun Myint Eric Bessell Lindsay C Thompson Mahesh Parmar Richard J Stephens David Sebag-Montefiore | 2009 | The Lancet2009，，9666： | 1 |
| 11 | Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial显示文摘 | Phil Quirke Robert Steele John Monson Robert Grieve Subhash Khanna Jean Couture Chris O’Callaghan Arthur Sun Myint Eric Bessell Lindsay C Thompson Mahesh Parmar Richard J Stephens David Sebag-Montefiore | 2009 | The Lancet . 2009 (9666)2009，，9666： | 1 |
| 12 | Experimental and modeling studies of a Brillouin amplifier 显示文摘 | Allan A Offenberger David C Thompson Robert Fedosejevs J Santiago H R Manjunath | 1993 | IEEE J Ouantum Electron1993，29，1： | 1 |
| 13 | Vitronectin Inhibits Neutrophil Apoptosis through Activation of Integrin-Associated Signaling Pathways显示文摘 | Bae Hong-Beom Zmijewski Jaroslaw W Deshane Jessy S Zhi Degui Thompson Lawrence C Peterson Cynthia B Chaplin David D Abraham Edward | 2012 | EN2012，，6： | 1 |
| 14 | Anatomical bases of sex‐ and size‐related acoustic variation in herring gull alarm calls显示文摘 | Lo?c A. Hardouin Richard Thompson Martyn Stenning David Reby | 2014 | Journal of Avian Biology2014，，： | 1 |
| 15 | Precision and accuracy of serum ferritin measurements显示文摘 | DAVID A L SKIKNE A THOMPSON C | 1981 | Am J Clin Nutr1981，34，： | 1 |
| 16 | The spectrum of GI strongyloidiasis: an endoscopic-pathologic study显示文摘 | Bryan F Thompson Luc??a C Fry Christopher D Wells Mart??n Olmos David H Lee Audrey J Lazenby Klaus E M?nkemüller | 2004 | Gastrointestinal Endoscopy2004，，7： | 1 |
| 17 | Depression among Chinese stroke survivorssix months after dis- chargefmm a rehabilitation hospital 显示文摘 | Janita P&C Chau David R Thompson Anne M Chang | 2010 | Journal of Clinical Nurs- ing2010，19，： | 1 |
| 18 | Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures显示文摘 | Dennis M Black Steven R Cummings David B Karpf Jane A Cauley Desmond E Thompson Michael C Nevitt Douglas C Bauer Harry K Genant William L Haskell Robert Marcus Susan M Ott James C Torner Sara A Quandt Theodore F Reiss Kristine E Ensrud | 1996 | The Lancet1996，，9041： | 1 |
| 19 | Outcome of Reproductive Age Women with Stage IA or IC Invasive Epithelial Ovarian Cancer Treated with Fertility-Sparing Therapy显示文摘 | Jeanne M Schilder Amy M Thompson Paul D DePriest Frederick R Ueland Michael L Cibull Richard J Kryscio Susan C Modesitt Karen H Lu John P Geisler Robert V Higgins Paul M Magtibay David E Cohn Matthew A Powell Christina Chu Frederick B Stehman John van Nag | 2002 | Gynecologic Oncology2002，，： | 1 |
| 20 | Experimental and modeling studies of a Brillouin amplifier显示文摘 | Offenberger Allan A Thompson David C Fedosejevs Robert | 1993 | IEEE Journal of Quantum Electronics1993，29，1： | 1 |
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